Literature DB >> 32643907

Adverse Drug Reaction: Midazolam-Induced Extrapyramidal Symptoms: A Case Report.

Margaux M McConn1, Joseph T Gundy, Suzanne B Karan, Danielle M Lindenmuth.   

Abstract

Midazolam is commonly used for sedation during procedures because of its relative safety and predictability. Still, some rare undesirable medication reactions have been described. We report a case in which midazolam given before a peripheral nerve block caused acute onset dyskinetic extrapyramidal symptoms. These symptoms ultimately resolved following reversal of the midazolam with flumazenil. Given the widespread and multidisciplinary use of midazolam, practitioners should be aware of the potential for rare adverse reactions and be prepared to manage these scenarios.

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Year:  2020        PMID: 32643907      PMCID: PMC7323825          DOI: 10.1213/XAA.0000000000001248

Source DB:  PubMed          Journal:  A A Pract        ISSN: 2575-3126


  14 in total

1.  Emergency psychiatry: extrapyramidal side effects in the psychiatric emergency service.

Authors:  J Kamin; S Manwani; D Hughes
Journal:  Psychiatr Serv       Date:  2000-03       Impact factor: 3.084

2.  Midazolam-induced dyskinesia.

Authors:  A Davies
Journal:  Palliat Med       Date:  2000-09       Impact factor: 4.762

3.  Subcutaneous midazolam as a cause of extrapyramidal side effects in a patient with prostate cancer.

Authors:  Duncan J F Brown; Dorothy McArthur; Helen Moulsdale
Journal:  J Pain Symptom Manage       Date:  2007-06-28       Impact factor: 3.612

4.  Midazolam-induced extrapyramidal side effects.

Authors:  Eric E Prommer
Journal:  J Pain Symptom Manage       Date:  2008-08-26       Impact factor: 3.612

5.  Benzodiazepines and tardive dyskinesia.

Authors:  A H Rosenbaum; J R de la Fluente
Journal:  Lancet       Date:  1979-10-27       Impact factor: 79.321

Review 6.  The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature.

Authors:  A A Weinbroum; O Szold; D Ogorek; R Flaishon
Journal:  Eur J Anaesthesiol       Date:  2001-12       Impact factor: 4.330

Review 7.  Disinhibitory reactions to benzodiazepines: a review.

Authors:  P van der Bijl; J A Roelofse
Journal:  J Oral Maxillofac Surg       Date:  1991-05       Impact factor: 1.895

8.  Gender differences in tardive dyskinesia: a critical review of the literature.

Authors:  R Yassa; D V Jeste
Journal:  Schizophr Bull       Date:  1992       Impact factor: 9.306

9.  Midazolam-induced athetoid movements of the lower extremities during epidural anesthesia reversed by physostigmine.

Authors:  G J Vorsanger; J T Roberts
Journal:  J Clin Anesth       Date:  1993 Nov-Dec       Impact factor: 9.452

10.  Midazolam-induced acute dystonia reversed by diazepam.

Authors:  Mustafa Komur; Ali Ertug Arslankoylu; Cetin Okuyaz
Journal:  J Anaesthesiol Clin Pharmacol       Date:  2012-07
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