Literature DB >> 3264200

EGF binding is quantitatively related to growth in node-positive breast cancer.

E Spitzer1, K Koepke, D Kunde, R Grosse.   

Abstract

Number of mitoses and EGF binding were determined in parallel in biopsies of 27 lymph-node positive and of 23 lymph-node negative breast cancer patients. For node-positive patients the parameters for cell growth and EGF binding were quantitatively correlated by the equation y = P3 + P1(1- exp(- P2x]. For node-negative cases neither the non-linear model nor the linear approximation described the data unambiguously. The results strongly suggest that in node-positive patients, growth of breast cancer is related to an EGF-dependent acceleration of cell division.

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Year:  1988        PMID： 3264200     DOI： 10.1007/bf01805739

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN： 0167-6806            Impact factor:   4.872


  15 in total

1.  Growth of normal human mammary cells in culture.

Authors:  M Stampfer; R C Hallowes; A J Hackett
Journal:  In Vitro       Date:  1980-05

2.  Receptors for epidermal growth factor in human mammary carcinomas and their metastases.

Authors:  A Macias; E Azavedo; R Perez; L E Rutqvist; L Skoog
Journal:  Anticancer Res       Date:  1986 Jul-Aug       Impact factor: 2.480

3.  Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.

Authors:  D J Slamon; G M Clark; S G Wong; W J Levin; A Ullrich; W L McGuire
Journal:  Science       Date:  1987-01-09       Impact factor: 47.728

4.  Epidermal growth factor receptors and effect of epidermal growth factor on growth of human breast cancer cells in long-term tissue culture.

Authors:  Y Imai; C K Leung; H G Friesen; R P Shiu
Journal:  Cancer Res       Date:  1982-11       Impact factor: 12.701

5.  Epidermal growth factor receptors in human breast cancer.

Authors:  R Pérez; M Pascual; A Macías; A Lage
Journal:  Breast Cancer Res Treat       Date:  1984       Impact factor: 4.872

6.  Biological effect of epidermal growth factor on the in vitro growth of human tumors.

Authors:  S E Singletary; F L Baker; G Spitzer; S L Tucker; B Tomasovic; W A Brock; J A Ajani; A M Kelly
Journal:  Cancer Res       Date:  1987-01-15       Impact factor: 12.701

7.  Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels.

Authors:  S L Fitzpatrick; J Brightwell; J L Wittliff; G H Barrows; G S Schultz
Journal:  Cancer Res       Date:  1984-08       Impact factor: 12.701

8.  Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture.

Authors:  S L Fitzpatrick; M P LaChance; G S Schultz
Journal:  Cancer Res       Date:  1984-08       Impact factor: 12.701

9.  Epidermal-growth-factor receptors and oestrogen receptors in human breast cancer.

Authors:  J R Sainsbury; J R Farndon; G V Sherbet; A L Harris
Journal:  Lancet       Date:  1985-02-16       Impact factor: 79.321

10.  Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours.

Authors:  D E Neal; C Marsh; M K Bennett; P D Abel; R R Hall; J R Sainsbury; A L Harris
Journal:  Lancet       Date:  1985-02-16       Impact factor: 79.321
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  2 in total

1.  Effects of growth factors on proliferation on basal and luminal cells in human breast epithelial explants in serum-free culture.

Authors:  N P Perusinghe; P Monaghan; M J O'Hare; S Ashley; B A Gusterson
Journal:  In Vitro Cell Dev Biol       Date:  1992-02

2.  Clinical value of enzyme immunoassay of epidermal growth factor receptor in human breast cancer.

Authors:  H Iwase; S Kobayashi; Y Itoh; T Kuzushima; H Yamashita; H Iwata; A Naito; T Yamashita; K Itoh; A Masaoka
Journal:  Breast Cancer Res Treat       Date:  1993-12       Impact factor: 4.872
  2 in total

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