Literature DB >> 3264157

Epidermal-growth-factor stimulation of gluconeogenesis in isolated rat hepatocytes involves the inactivation of pyruvate kinase.

S K Moule1, J F McGivan.   

Abstract

Preincubation of rat hepatocytes with EGF (epidermal growth factor) caused a stimulation of gluconeogenesis from alanine. The effect was maximal after preincubation of 20 min, and a half-maximal effect of EGF was obtained at 10 nM. EGF also stimulated gluconeogenesis from lactate and asparagine, but not from glutamine or from proline. Preincubation of hepatocytes with EGF caused a stable inactivation of pyruvate kinase, which may account, at least in part, for the observed effects of EGF on gluconeogenesis.

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Year:  1988        PMID： 3264157      PMCID： PMC1135231     

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

1.  Epidermal growth factor counteracts the glycogenic effect of insulin in parenchymal hepatocyte cultures.

Authors:  M H Chowdhury; L Agius
Journal:  Biochem J       Date:  1987-10-15       Impact factor: 3.857

Review 2.  Epidermal growth factor.

Authors:  G Carpenter; S Cohen
Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

3.  Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues.

Authors:  E O'Keefe; M D Hollenberg; P Cuatrecasas
Journal:  Arch Biochem Biophys       Date:  1974-10       Impact factor: 4.013

4.  Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen.

Authors:  P Trinder
Journal:  J Clin Pathol       Date:  1969-03       Impact factor: 3.411

5.  The kinetics of transport of lactate and pyruvate into rat hepatocytes. Evidence for the presence of a specific carrier similar to that in erythrocytes.

Authors:  G L Edlund; A P Halestrap
Journal:  Biochem J       Date:  1988-01-01       Impact factor: 3.857

6.  Epidermal growth factor stimulates monovalent cation transport in isolated rat hepatocytes.

Authors:  M Fehlmann; B Canivet; P Freychet
Journal:  Biochem Biophys Res Commun       Date:  1981-05-15       Impact factor: 3.575

7.  Plasma-membrane transport of alanine is rate-limiting for its metabolism in rat-liver parenchymal cells.

Authors:  H J Sips; A K Groen; J M Tager
Journal:  FEBS Lett       Date:  1980-10-06       Impact factor: 4.124

8.  Acute regulation of pyruvate kinase activity in rat epididymal adipose tissue by insulin.

Authors:  R M Denton; N J Edgell; B J Bridges; G P Poole
Journal:  Biochem J       Date:  1979-06-15       Impact factor: 3.857

9.  Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate.

Authors:  R M Johnson; J C Garrison
Journal:  J Biol Chem       Date:  1987-12-25       Impact factor: 5.157

10.  Hepatic pyruvate kinase. Regulation by glucagon, cyclic adenosine 3'-5'-monophosphate, and insulin in the perfused rat liver.

Authors:  J B Blair; M A Cimbala; J L Foster; R A Morgan
Journal:  J Biol Chem       Date:  1976-06-25       Impact factor: 5.157
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  3 in total

1.  Epidermal growth factor administration decreases liver glycogen and causes mild hyperglycaemia in mice.

Authors:  M Grau; F Tebar; I Ramírez; M Soley
Journal:  Biochem J       Date:  1996-04-01       Impact factor: 3.857

2.  The early stimulation of glycolysis by epidermal growth factor in isolated rat hepatocytes is secondary to the glycogenolytic effect.

Authors:  I Quintana; M Grau; F Moreno; C Soler; I Ramírez; M Soley
Journal:  Biochem J       Date:  1995-06-15       Impact factor: 3.857

3.  Rapid and delayed effects of epidermal growth factor on gluconeogenesis.

Authors:  C Soler; M Soley
Journal:  Biochem J       Date:  1993-09-15       Impact factor: 3.857
  3 in total

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