Literature DB >> 32637872

Should there be a specific length of the colon-rectum segment to be resected for an adequate number of lymph nodes in cases of colorectal cancers? A retrospective multi-center study.

Orhan Üreyen1, Cemal Ulusoy2, Atahan Acar3, Fazıl Sağlam2, İlker Kızıloğlu1, Ali Alemdar2, Kemal Murat Atahan3, Emrah Dadalı1, Serkan Karaisli3, Mehmet Can Aydın2, Enver İlhan1, Hakan Güven2.   

Abstract

OBJECTIVES: This study aimed to evaluate the question as to whether there should be a certain length of the colon-rectum segment to be resected for correct lymph node staging in cases with colorectal cancer.
MATERIAL AND METHODS: The files and electronic datas of the patients had been undergone surgery for colorectal cancer between January 2011 and June 2016 were evaluated. The patients were divided into two groups; Group I= ≥ 12 lymph nodes, and Group II= lymph nodes less than 12 ( <12) lymph nodes.
RESULTS: Mean age of the 327 participants in this study was 64.30 ± 12.20. Mean length of resected colon-rectum segment was 25.61 (± 14.07) cm; mean number of dissected lymph nodes was 20.63 ± 12.30. Median length of the resected colon was 24 cm (range: 145-6) in Group I and 20 cm (range: 52-9) in Group II; a significant difference was found between the groups (p= 0.002). Factors associated with adequate lymph node dissection included type of the operation (p= 0.001), tumor location (p= 0.005), tumor T stage (p= 0.001), condition of metastasis in the lymph node (p= 0.008) and stage of the disease (p= 0.031). Overall survival was 62.4 ± 1.31 months, and Group I and Group II survival was 61.4 ± 1.39 months and 66.7 ± 3.25 months, respectively (p= 0.449).
CONCLUSION: Results of the study showed that ≥ 12 lymph nodes would likely be dissected when the length of the resected colon-rectum segment is > 21 cm. We conclude that the removed colonic size can be significant when performed with oncological surgical standardization.
Copyright © 2020, Turkish Surgical Society.

Entities:  

Keywords:  Colorectal cancer; colectomy; lymph nodes

Year:  2020        PMID: 32637872      PMCID: PMC7315459          DOI: 10.5578/turkjsurg.4550

Source DB:  PubMed          Journal:  Turk J Surg        ISSN: 2564-6850


  17 in total

Review 1.  Lymphatic spread, nodal count and the extent of lymphadenectomy in cancer of the colon.

Authors:  Wouter Willaert; Marc Mareel; Dirk Van De Putte; Yves Van Nieuwenhove; Piet Pattyn; Wim Ceelen
Journal:  Cancer Treat Rev       Date:  2013-09-25       Impact factor: 12.111

2.  Linking surgical specimen length and examined lymph nodes in colorectal cancer patients.

Authors:  F Stracci; F Bianconi; S Leite; A Liso; F La Rosa; V Lancellotta; C J H van de Velde; C Aristei
Journal:  Eur J Surg Oncol       Date:  2015-12-17       Impact factor: 4.424

3.  Lymph node retrieval for colorectal cancer: Estimation of the minimum resection length to achieve at least 12 lymph nodes for the pathological analysis.

Authors:  Gianpiero Gravante; Rupert Parker; Mohamed Elshaer; Adimabua Christopher Mogekwu; Nada Humayun; Katie Thomas; Rachael Thomson; Sarah Hudson; Roberto Sorge; Katy Gardiner; Salem Al-Hamali; Mohamed Rashed; Ashish Kelkar; Saleem El-Rabaa
Journal:  Int J Surg       Date:  2015-12-20       Impact factor: 6.071

4.  The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.

Authors:  Stephen B Edge; Carolyn C Compton
Journal:  Ann Surg Oncol       Date:  2010-06       Impact factor: 5.344

5.  Individual surgeon, pathologist, and other factors affecting lymph node harvest in stage II colon carcinoma. is a minimum of 12 examined lymph nodes sufficient?

Authors:  Luca Stocchi; Victor W Fazio; Ian Lavery; Jeff Hammel
Journal:  Ann Surg Oncol       Date:  2010-09-14       Impact factor: 5.344

6.  A predictive model for lymph node yield in colon cancer resection specimens.

Authors:  Garrett M Nash; David Row; Alexander Weiss; Jinru Shia; Jose G Guillem; Philip B Paty; Mithat Gonen; Martin R Weiser; Larissa K Temple; Garrett Fitzmaurice; W Douglas Wong
Journal:  Ann Surg       Date:  2011-02       Impact factor: 12.969

Review 7.  Extent of surgery in cancer of the colon: is more better?

Authors:  Wouter Willaert; Wim Ceelen
Journal:  World J Gastroenterol       Date:  2015-01-07       Impact factor: 5.742

8.  Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology.

Authors:  Toru Nawa; Jun Kato; Hirofumi Kawamoto; Hiroyuki Okada; Hiroshi Yamamoto; Hiroyuki Kohno; Hisayuki Endo; Yasushi Shiratori
Journal:  J Gastroenterol Hepatol       Date:  2007-05-27       Impact factor: 4.029

9.  The prognostic significance of total lymph node harvest in patients with T2-4N0M0 colorectal cancer.

Authors:  Hsiang-Lin Tsai; Chien-Yu Lu; Jan-Sing Hsieh; Deng-Chyang Wu; Chang-Ming Jan; Chee-Yin Chai; Koung Shing Chu; Hon-Man Chan; Jaw-Yuan Wang
Journal:  J Gastrointest Surg       Date:  2007-05       Impact factor: 3.267

10.  Impact of bowel resection margins in node negative colon cancer.

Authors:  Ricardo Rocha; Rui Marinho; David Aparício; Marta Fragoso; Marta Sousa; António Gomes; Carlos Leichsenring; Carla Carneiro; Vasco Geraldes; Vítor Nunes
Journal:  Springerplus       Date:  2016-11-11
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