Steffen Wolfsgruber1,2, Luca Kleineidam3,2, Jannis Guski3,2, Alexandra Polcher3,2, Ingo Frommann3,2, Sandra Roeske3, Eike Jakob Spruth4,5, Christiana Franke5, Josef Priller4,5, Ingo Kilimann6,7, Stefan Teipel6,7, Katharina Buerger8,9, Daniel Janowitz9, Christoph Laske10,11, Martina Buchmann10,11, Oliver Peters4,12, Felix Menne4,12, Manuel Fuentes Casan4,12, Jens Wiltfang13,14, Claudia Bartels13,14, Emrah Düzel15,16, Coraline Metzger15,16,17, Wenzel Glanz16, Manuela Thelen3,18, Annika Spottke3,19, Alfredo Ramirez3,2,20, Barbara Kofler3,2, Klaus Fließbach3,2, Anja Schneider3,2, Michael Heneka3,2, Frederic Brosseron3,2, Dix Meiberth3,18, Frank Jessen3,18, Michael Wagner3,2. 1. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Steffen.Wolfsgruber@dzne.de. 2. Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Germany. 3. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. 4. German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany. 5. Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Germany. 6. German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany. 7. Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany. 8. German Center for Neurodegenerative Diseases (DZNE) Munich, Germany. 9. Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany. 10. German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. 11. Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Germany. 12. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Berlin, Germany. 13. German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany. 14. Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Germany. 15. German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. 16. Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany. 17. Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany. 18. Department of Psychiatry, Medical Faculty University of Cologne, Germany. 19. Department of Neurology, University Hospital Bonn, Germany. 20. Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry, Medical Faculty University of Cologne, Germany.
Abstract
OBJECTIVE: To determine the nature and extent of minor neuropsychological deficits in patients with subjective cognitive decline (SCD) and their association with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD). METHOD: We analyzed data from n=449 cognitively normal participants (n=209 healthy controls, n=240 SCD patients) from an interim data release of the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE). An extensive neuropsychological test battery was applied at baseline for which we established a latent, five cognitive domain factor structure comprising learning & memory, executive functions, language abilities, working memory and visuospatial functions. We compared groups regarding global and domain-specific performance and correlated performance with different CSF markers of AD pathology. RESULTS: We observed worse performance (Cohen's d≈0.25-0.5, adjusted for age-, sex differences with ANCOVA) in global performance, memory, executive functions and language abilities for the SCD group compared to healthy controls. In addition, worse performance in these domains was moderately (r≈0.3) associated with lower CSF-Aβ42/40 and CSF-Aβ42/ptau181 in the whole sample and specifically in the SCD subgroup. CONCLUSIONS: Within the spectrum of clinically unimpaired (i.e., "pre- mild cognitive impairment") cognitive performance, SCD is associated with minor deficits in memory, executive function and language abilities. The association of these subtle cognitive deficits with AD CSF biomarkers speaks to their validity and potential use for the early detection of underlying preclinical AD.
OBJECTIVE: To determine the nature and extent of minor neuropsychological deficits in patients with subjective cognitive decline (SCD) and their association with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD). METHOD: We analyzed data from n=449 cognitively normal participants (n=209 healthy controls, n=240 SCD patients) from an interim data release of the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE). An extensive neuropsychological test battery was applied at baseline for which we established a latent, five cognitive domain factor structure comprising learning & memory, executive functions, language abilities, working memory and visuospatial functions. We compared groups regarding global and domain-specific performance and correlated performance with different CSF markers of AD pathology. RESULTS: We observed worse performance (Cohen's d≈0.25-0.5, adjusted for age-, sex differences with ANCOVA) in global performance, memory, executive functions and language abilities for the SCD group compared to healthy controls. In addition, worse performance in these domains was moderately (r≈0.3) associated with lower CSF-Aβ42/40 and CSF-Aβ42/ptau181 in the whole sample and specifically in the SCD subgroup. CONCLUSIONS: Within the spectrum of clinically unimpaired (i.e., "pre- mild cognitive impairment") cognitive performance, SCD is associated with minor deficits in memory, executive function and language abilities. The association of these subtle cognitive deficits with AD CSF biomarkers speaks to their validity and potential use for the early detection of underlying preclinical AD.
Authors: Tim Whitfield; Harriet Demnitz-King; Fabienne Collette; Miranka Wirth; Marco Schlosser; Thorsten Barnhofer; Eric Frison; Nina Coll-Padros; Sophie Dautricourt; Florence Requier; Marion Delarue; Julie Gonneaud; Olga M Klimecki; Antoine Lutz; Léo Paly; Eric Salmon; Ann-Katrin Schild; Zuzana Walker; Frank Jessen; Gaël Chételat; Natalie L Marchant Journal: Alzheimers Res Ther Date: 2022-09-06 Impact factor: 8.823
Authors: Tommaso Ballarini; Debora Melo van Lent; Julia Brunner; Alina Schröder; Steffen Wolfsgruber; Slawek Altenstein; Frederic Brosseron; Katharina Buerger; Peter Dechent; Laura Dobisch; Emrah Duzel; Birgit Ertl-Wagner; Klaus Fliessbach; Silka Dawn Freiesleben; Ingo Frommann; Wenzel Glanz; Dietmar Hauser; John Dylan Haynes; Michael T Heneka; Daniel Janowitz; Ingo Kilimann; Christoph Laske; Franziska Maier; Coraline Danielle Metzger; Matthias Munk; Robert Perneczky; Oliver Peters; Josef Priller; Alfredo Ramirez; Boris Rauchmann; Nina Roy; Klaus Scheffler; Anja Schneider; Annika Spottke; Eike Jakob Spruth; Stefan J Teipel; Ruth Vukovich; Jens Wiltfang; Frank Jessen; Michael Wagner Journal: Neurology Date: 2021-05-05 Impact factor: 9.910
Authors: L M P Wesselman; D Melo van Lent; A Schröder; O van de Rest; O Peters; F Menne; M Fuentes; J Priller; E J Spruth; S Altenstein; A Schneider; K Fließbach; S Roeske; S Wolfsgruber; L Kleineidam; A Spottke; V Pross; J Wiltfang; R Vukovich; A K Schild; E Düzel; C D Metzger; W Glanz; K Buerger; D Janowitz; R Perneczky; M Tatò; S Teipel; I Kilimann; C Laske; M Buchmann; A Ramirez; S A M Sikkes; F Jessen; W M van der Flier; M Wagner Journal: Eur J Nutr Date: 2020-05-29 Impact factor: 5.614
Authors: Ornella V Billette; Gabriel Ziegler; Merita Aruci; Hartmut Schütze; Jasmin M Kizilirmak; Anni Richter; Slawek Altenstein; Claudia Bartels; Frederic Brosseron; Arturo Cardenas-Blanco; Philip Dahmen; Peter Dechent; Laura Dobisch; Klaus Fliessbach; Silka Dawn Freiesleben; Wenzel Glanz; Doreen Göerß; John Dylan Haynes; Michael T Heneka; Ingo Kilimann; Okka Kimmich; Luca Kleineidam; Christoph Laske; Andrea Lohse; Ayda Rostamzadeh; Coraline Metzger; Matthias H Munk; Oliver Peters; Lukas Preis; Josef Priller; Klaus Scheffler; Anja Schneider; Annika Spottke; Eike Jakob Spruth; Alfredo Ramirez; Sandra Röske; Nina Roy; Stefan Teipel; Michael Wagner; Jens Wiltfang; Steffen Wolfsgruber; Renat Yakupov; Peter Zeidman; Frank Jessen; Björn H Schott; Emrah Düzel; Anne Maass Journal: Neurology Date: 2022-06-03 Impact factor: 11.800
Authors: Rachel L Nosheny; Rebecca Amariglio; Sietske A M Sikkes; Carol Van Hulle; Maria Aparecida Camargos Bicalho; N Maritza Dowling; Sonia Maria Dozzi Brucki; Zahinoor Ismail; Kensaku Kasuga; Elizabeth Kuhn; Katya Numbers; Anna Aaronson; Davide Vito Moretti; Arturo X Pereiro; Gonzalo Sánchez-Benavides; Allis F Sellek Rodríguez; Prabitha Urwyler; Kristina Zawaly Journal: Alzheimers Dement (N Y) Date: 2022-10-04