Todd M Manini1, Sheena M Patel2, Anne B Newman3, Thomas G Travison4, Douglas P Kiel4, Michelle D Shardell5, Karol M Pencina4, Kevin E Wilson6, Thomas L Kelly6, Joseph M Massaro7, Roger A Fielding8, Jay Magaziner9, Rosaly Correa-de-Araujo10, Timothy C Y Kwok11, Vasant Hirani12, Magnus K Karlsson13, Ralph B DʼAgostino14, Dan Mellström15, Claes Ohlsson15, Eva Ribom16, Joanne M Jordan17, Shalender Bhasin4, Peggy M Cawthon2. 1. Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida, USA. 2. California Pacific Medical Research Institute, San Francisco, California, USA. 3. Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 4. Department of Medicine, Harvard Medical School and Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA. 5. Institute for Genomes Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA. 6. Hologic, Inc, Marlborough, Massachusetts, USA. 7. Department of Biostatistics, Boston University, Boston, Massachusetts, USA. 8. Tufts University, Boston, Massachusetts, USA. 9. Department of Epidemiology, University of Maryland Baltimore, Baltimore, Maryland, USA. 10. Division of Geriatrics and Clinical Gerontology, US Department of Health and Human Services, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA. 11. The Chinese University, Hong Kong Special Administrative Region, China. 12. University of Sydney, Sydney, New South Wales, Australia. 13. Lund University, Skane University Hospital, Malmo, Sweden. 14. Boston University, Boston, Massachusetts, USA. 15. University of Gothenburg, Gothenburg, Sweden. 16. Uppsala University, Uppsala, Sweden. 17. University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Abstract
BACKGROUND: The Sarcopenia Definitions and Outcomes Consortium (SDOC) sought to identify cut points for muscle strength and body composition measures derived from dual-energy x-ray absorptiometry (DXA) that discriminate older adults with slow walking speed. This article presents the core analyses used to guide the SDOC position statements. DESIGN: Cross-sectional data analyses of pooled data. SETTING: University-based research assessment centers. PARTICIPANTS: Community-dwelling men (n = 13,652) and women: (n = 5,115) with information on lean mass by DXA, grip strength (GR), and walking speed. MEASUREMENTS: Thirty-five candidate sarcopenia variables were entered into sex-stratified classification and regression tree (CART) models to agnostically choose variables and cut points that discriminate slow walkers (<0.80 m/s). Models with alternative walking speed outcomes were also evaluated (<0.60 and <1.0 m/s and walking speed treated continuously). RESULTS: CART models identified GR/body mass index (GRBMI) and GR/total body fat (GRTBF) as the primary discriminating variables for slowness in men and women, respectively. Men with GRBMI of 1.05 kg/kg/m2 or less were approximately four times more likely to be slow walkers than those with GRBMI of greater than 1.05 kg/kg/m2 . Women with GRTBF of less than 0.65 kg/kg were twice as likely to be slow walkers than women with GRTBF of 0.65 kg/kg or greater. Models with alternative walking speed outcomes selected only functions of GR as primary discriminators of slowness in both men and women. DXA-derived lean mass measures did not consistently discriminate slow walkers. CONCLUSION: GR with and without adjustments for body size and composition consistently discriminated older adults with slowness. CART models did not select DXA-based lean mass as a primary discriminator of slowness. These results were presented to an SDOC Consensus Panel, who used them and other information to develop the SDOC Position Statements. J Am Geriatr Soc 68:1419-1428, 2020.
BACKGROUND: The Sarcopenia Definitions and Outcomes Consortium (SDOC) sought to identify cut points for muscle strength and body composition measures derived from dual-energy x-ray absorptiometry (DXA) that discriminate older adults with slow walking speed. This article presents the core analyses used to guide the SDOC position statements. DESIGN: Cross-sectional data analyses of pooled data. SETTING: University-based research assessment centers. PARTICIPANTS: Community-dwelling men (n = 13,652) and women: (n = 5,115) with information on lean mass by DXA, grip strength (GR), and walking speed. MEASUREMENTS: Thirty-five candidate sarcopenia variables were entered into sex-stratified classification and regression tree (CART) models to agnostically choose variables and cut points that discriminate slow walkers (<0.80 m/s). Models with alternative walking speed outcomes were also evaluated (<0.60 and <1.0 m/s and walking speed treated continuously). RESULTS: CART models identified GR/body mass index (GRBMI) and GR/total body fat (GRTBF) as the primary discriminating variables for slowness in men and women, respectively. Men with GRBMI of 1.05 kg/kg/m2 or less were approximately four times more likely to be slow walkers than those with GRBMI of greater than 1.05 kg/kg/m2 . Women with GRTBF of less than 0.65 kg/kg were twice as likely to be slow walkers than women with GRTBF of 0.65 kg/kg or greater. Models with alternative walking speed outcomes selected only functions of GR as primary discriminators of slowness in both men and women. DXA-derived lean mass measures did not consistently discriminate slow walkers. CONCLUSION: GR with and without adjustments for body size and composition consistently discriminated older adults with slowness. CART models did not select DXA-based lean mass as a primary discriminator of slowness. These results were presented to an SDOC Consensus Panel, who used them and other information to develop the SDOC Position Statements. J Am Geriatr Soc 68:1419-1428, 2020.
Authors: J M Guralnik; L Ferrucci; C F Pieper; S G Leveille; K S Markides; G V Ostir; S Studenski; L F Berkman; R B Wallace Journal: J Gerontol A Biol Sci Med Sci Date: 2000-04 Impact factor: 6.053
Authors: Jama L Purser; Morris Weinberger; Harvey J Cohen; Carl F Pieper; Miriam C Morey; Tracy Li; G Rhys Williams; Pablo Lapuerta Journal: J Rehabil Res Dev Date: 2005 Jul-Aug
Authors: Peggy M Cawthon; Thomas G Travison; Todd M Manini; Sheena Patel; Karol M Pencina; Roger A Fielding; Jay M Magaziner; Anne B Newman; Todd Brown; Douglas P Kiel; Steve R Cummings; Michelle Shardell; Jack M Guralnik; Linda J Woodhouse; Marco Pahor; Ellen Binder; Ralph B D'Agostino; Xue Quian-Li; Eric Orwoll; Francesco Landi; Denise Orwig; Laura Schaap; Nancy K Latham; Vasant Hirani; Timothy Kwok; Suzette L Pereira; Daniel Rooks; Makoto Kashiwa; Moises Torres-Gonzalez; Joseph P Menetski; Rosaly Correa-De-Araujo; Shalender Bhasin Journal: J Gerontol A Biol Sci Med Sci Date: 2020-06-18 Impact factor: 6.053
Authors: Roger A Fielding; Bruno Vellas; William J Evans; Shalender Bhasin; John E Morley; Anne B Newman; Gabor Abellan van Kan; Sandrine Andrieu; Juergen Bauer; Denis Breuille; Tommy Cederholm; Julie Chandler; Capucine De Meynard; Lorenzo Donini; Tamara Harris; Aimo Kannt; Florence Keime Guibert; Graziano Onder; Dimitris Papanicolaou; Yves Rolland; Daniel Rooks; Cornel Sieber; Elisabeth Souhami; Sjors Verlaan; Mauro Zamboni Journal: J Am Med Dir Assoc Date: 2011-03-04 Impact factor: 4.669
Authors: Graziano Onder; Brenda W J H Penninx; Luigi Ferrucci; Linda P Fried; Jack M Guralnik; Marco Pahor Journal: J Gerontol A Biol Sci Med Sci Date: 2005-01 Impact factor: 6.053
Authors: Peggy M Cawthon; Todd Manini; Sheena M Patel; Anne Newman; Thomas Travison; Douglas P Kiel; Adam J Santanasto; Kristine E Ensrud; Qian-Li Xue; Michelle Shardell; Kate Duchowny; Kristine M Erlandson; Karol M Pencina; Roger A Fielding; Jay Magaziner; Timothy Kwok; Magnus Karlsson; Claes Ohlsson; Dan Mellström; Vasant Hirani; Eva Ribom; Rosaly Correa-de-Araujo; Shalender Bhasin Journal: J Am Geriatr Soc Date: 2020-07-07 Impact factor: 5.562
Authors: Denise L Orwig; Jay Magaziner; Roger A Fielding; Hao Zhu; Ellen F Binder; Peggy M Cawthon; Shalender Bhasin; Rosaly Correa-de-Araujo; Todd Manini; Sheena Patel; Michelle Shardell; Thomas G Travison Journal: J Gerontol A Biol Sci Med Sci Date: 2020-06-18 Impact factor: 6.053
Authors: Gregory J Grosicki; Thomas G Travison; Hao Zhu; Jay Magaziner; Ellen F Binder; Marco Pahor; Rosaly Correa-de-Araujo; Peggy M Cawthon; Shalender Bhasin; Denise Orwig; Susan Greenspan; Todd Manini; Joe Massaro; Adam Santanasto; Sheena Patel; Roger A Fielding Journal: J Am Geriatr Soc Date: 2020-07-07 Impact factor: 5.562
Authors: Aron S Buchman; Sue E Leurgans; Tianhao Wang; Michal Schnaider-Beeri; Puja Agarwal; Robert J Dawe; Osvaldo Delbono; David A Bennett Journal: PLoS One Date: 2021-02-02 Impact factor: 3.240
Authors: Chen Bai; Amal A Wanigatunga; Santiago Saldana; Ramon Casanova; Todd M Manini; Mamoun T Mardini Journal: Sensors (Basel) Date: 2022-04-15 Impact factor: 3.847
Authors: Alex Barreto de Lima; Duarte Henrinques-Neto; Gustavo Dos Santos Ribeiro; Elvio Rúbio Gouveia; Fátima Baptista Journal: Int J Environ Res Public Health Date: 2022-07-29 Impact factor: 4.614
Authors: Anna K Stuck; Nina C Mäder; Dominic Bertschi; Andreas Limacher; Reto W Kressig Journal: Int J Environ Res Public Health Date: 2021-03-28 Impact factor: 3.390