Denise L Orwig1, Jay Magaziner1, Roger A Fielding2, Hao Zhu3, Ellen F Binder4, Peggy M Cawthon5,6, Shalender Bhasin7, Rosaly Correa-de-Araujo8, Todd Manini9, Sheena Patel5, Michelle Shardell1,10, Thomas G Travison3,11. 1. Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore. 2. Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts. 3. Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts. 4. Department of Medicine, Washington University School of Medicine, St. Louis, Missouri. 5. California Pacific Medical Research Institute, San Francisco. 6. Department of Epidemiology and Biostatistics, University of California, San Francisco. 7. Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Boston, Massachusetts. 8. Division of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, Maryland. 9. Department of Aging and Geriatric Research, University of Florida, Gainesville. 10. Longitudianl Studies Section, National Institute on Aging, Bethesda, Maryland. 11. Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Abstract
BACKGROUND: Sarcopenia is often conceptualized as a precursor to loss of mobility, but its effect on recovery of mobility after a hip fracture is unknown. We determined the prevalence of low muscle strength (weakness) after hip fracture using putative sarcopenia metrics (absolute grip strength, and grip strength normalized to body mass index, total body fat, arm lean mass, and weight) identified by the Sarcopenia Definitions and Outcomes Consortium (SDOC). METHODS: We examined two well-characterized hip fracture cohorts of community-dwelling older adults from the Baltimore Hip Studies (BHS). The prevalence of muscle weakness was assessed using the SDOC cut points compared to published definitions at 2 and 6 months postfracture. We assessed associations of 2-month weakness with 6-month walking speed <0.6 m/s and calculated the sensitivity and specificity in predicting lack of meaningful change in walking speed (change < 0.1 m/s) at 6 months. RESULTS: Two hundred and forty-six participants (192 women; 54 men) were included; mean (SD) age of 81 (8) for women and 78 (7) for men. At 2 months, 91% women and 78% men exhibited slow walking speed (< 0.6 m/s). SDOC grip strength standardized by weight (<0.34 kg women, <0.45 kg men) was the most prevalent measure of weakness in men (74%) and women (79%) and provided high sensitivity in men (86%) and women (84%) predicting lack of meaningful change in walking speed at 6 months, although specificity was poor to moderate. CONCLUSIONS: SDOC cut points for grip strength standardized to weight provided consistent indication of poor walking speed performance post-hip fracture.
BACKGROUND:Sarcopenia is often conceptualized as a precursor to loss of mobility, but its effect on recovery of mobility after a hip fracture is unknown. We determined the prevalence of low muscle strength (weakness) after hip fracture using putative sarcopenia metrics (absolute grip strength, and grip strength normalized to body mass index, total body fat, arm lean mass, and weight) identified by the Sarcopenia Definitions and Outcomes Consortium (SDOC). METHODS: We examined two well-characterized hip fracture cohorts of community-dwelling older adults from the Baltimore Hip Studies (BHS). The prevalence of muscle weakness was assessed using the SDOC cut points compared to published definitions at 2 and 6 months postfracture. We assessed associations of 2-month weakness with 6-month walking speed <0.6 m/s and calculated the sensitivity and specificity in predicting lack of meaningful change in walking speed (change < 0.1 m/s) at 6 months. RESULTS: Two hundred and forty-six participants (192 women; 54 men) were included; mean (SD) age of 81 (8) for women and 78 (7) for men. At 2 months, 91% women and 78% men exhibited slow walking speed (< 0.6 m/s). SDOC grip strength standardized by weight (<0.34 kg women, <0.45 kg men) was the most prevalent measure of weakness in men (74%) and women (79%) and provided high sensitivity in men (86%) and women (84%) predicting lack of meaningful change in walking speed at 6 months, although specificity was poor to moderate. CONCLUSIONS:SDOC cut points for grip strength standardized to weight provided consistent indication of poor walking speed performance post-hip fracture.
Authors: Marco Di Monaco; Fulvia Vallero; Roberto Di Monaco; Rosa Tappero; Alberto Cavanna Journal: Am J Phys Med Rehabil Date: 2006-03 Impact factor: 2.159
Authors: F Landi; R Calvani; E Ortolani; S Salini; A M Martone; L Santoro; A Santoliquido; A Sisto; A Picca; E Marzetti Journal: Osteoporos Int Date: 2017-02-02 Impact factor: 4.507
Authors: D Orwig; M C Hochberg; A L Gruber-Baldini; B Resnick; R R Miller; G E Hicks; A R Cappola; M Shardell; R Sterling; J R Hebel; R Johnson; J Magaziner Journal: J Frailty Aging Date: 2018
Authors: K M Fox; J Magaziner; W G Hawkes; J Yu-Yahiro; J R Hebel; S I Zimmerman; L Holder; R Michael Journal: Osteoporos Int Date: 2000 Impact factor: 4.507
Authors: Alfonso J Cruz-Jentoft; Jean Pierre Baeyens; Jürgen M Bauer; Yves Boirie; Tommy Cederholm; Francesco Landi; Finbarr C Martin; Jean-Pierre Michel; Yves Rolland; Stéphane M Schneider; Eva Topinková; Maurits Vandewoude; Mauro Zamboni Journal: Age Ageing Date: 2010-04-13 Impact factor: 10.668
Authors: Marco Di Monaco; Fulvia Vallero; Roberto Di Monaco; Rosa Tappero; Alberto Cavanna Journal: Am J Phys Med Rehabil Date: 2007-10 Impact factor: 2.159
Authors: Helen C Roberts; Hayley J Denison; Helen J Martin; Harnish P Patel; Holly Syddall; Cyrus Cooper; Avan Aihie Sayer Journal: Age Ageing Date: 2011-05-30 Impact factor: 10.668
Authors: Alfonso J Cruz-Jentoft; Gülistan Bahat; Jürgen Bauer; Yves Boirie; Olivier Bruyère; Tommy Cederholm; Cyrus Cooper; Francesco Landi; Yves Rolland; Avan Aihie Sayer; Stéphane M Schneider; Cornel C Sieber; Eva Topinkova; Maurits Vandewoude; Marjolein Visser; Mauro Zamboni Journal: Age Ageing Date: 2019-01-01 Impact factor: 10.668
Authors: Dawn E Alley; Michelle D Shardell; Katherine W Peters; Robert R McLean; Thuy-Tien L Dam; Anne M Kenny; Maren S Fragala; Tamara B Harris; Douglas P Kiel; Jack M Guralnik; Luigi Ferrucci; Stephen B Kritchevsky; Stephanie A Studenski; Maria T Vassileva; Peggy M Cawthon Journal: J Gerontol A Biol Sci Med Sci Date: 2014-05 Impact factor: 6.053
Authors: Lorenzo M Donini; Luca Busetto; Stephan C Bischoff; Tommy Cederholm; Maria D Ballesteros-Pomar; John A Batsis; Juergen M Bauer; Yves Boirie; Alfonso J Cruz-Jentoft; Dror Dicker; Stefano Frara; Gema Frühbeck; Laurence Genton; Yftach Gepner; Andrea Giustina; Maria Cristina Gonzalez; Ho-Seong Han; Steven B Heymsfield; Takashi Higashiguchi; Alessandro Laviano; Andrea Lenzi; Ibolya Nyulasi; Edda Parrinello; Eleonora Poggiogalle; Carla M Prado; Javier Salvador; Yves Rolland; Ferruccio Santini; Mireille J Serlie; Hanping Shi; Cornel C Sieber; Mario Siervo; Roberto Vettor; Dennis T Villareal; Dorothee Volkert; Jianchun Yu; Mauro Zamboni; Rocco Barazzoni Journal: Obes Facts Date: 2022-02-23 Impact factor: 4.807
Authors: Gregory J Grosicki; Thomas G Travison; Hao Zhu; Jay Magaziner; Ellen F Binder; Marco Pahor; Rosaly Correa-de-Araujo; Peggy M Cawthon; Shalender Bhasin; Denise Orwig; Susan Greenspan; Todd Manini; Joe Massaro; Adam Santanasto; Sheena Patel; Roger A Fielding Journal: J Am Geriatr Soc Date: 2020-07-07 Impact factor: 5.562
Authors: Ryan McGrath; Terri L Blackwell; Kristine E Ensrud; Brenda M Vincent; Peggy M Cawthon Journal: J Gerontol A Biol Sci Med Sci Date: 2021-08-13 Impact factor: 6.053
Authors: Johannes Gleich; Daniel Pfeufer; Alexander M Keppler; Stefan Mehaffey; Julian Fürmetz; Wolfgang Böcker; Christian Kammerlander; Carl Neuerburg Journal: Arch Orthop Trauma Surg Date: 2021-01-23 Impact factor: 2.928