Marco Mascitti1, Khrystyna Zhurakivska2, Lucrezia Togni1, Vito C A Caponio2, Alhadi Almangush3, Paolo Balercia4, Andrea Balercia4, Corrado Rubini5, Lorenzo Lo Muzio2, Andrea Santarelli1,6, Giuseppe Troiano2. 1. Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, Ancona, Italy. 2. Department of Clinical and Experimental Medicine, Foggia University, Foggia, Italy. 3. Department of Pathology, University of Helsinki, Helsinki, Finland. 4. Department of Oral and Head-Neck Surgery, Umberto I General Hospital, Ancona, Italy. 5. Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona, Italy. 6. National Institute of Health and Science of Ageing, IRCCS INRCA, Ancona, Italy.
Abstract
AIMS: One of the objectives of current research is to customise the treatment of cancer patients. The achievement of this objective requires stratification of patients based on the most significant prognostic factors. The aims of this study were to evaluate the prognostic value of the tumour-stroma ratio (TSR), defined as the proportion of tumour cells relative to surrounding stroma, in patients with oral tongue squamous cell carcinoma (OTSCC), and to develop a prognostic nomogram based on the most significant clinicopathological features. METHODS AND RESULTS: Clinicopathological data of 211 patients treated at 'Ospedali Riuniti' General Hospital (Ancona, Italy) for OTSCC were collected. One hundred and thirty-nine patients were restaged according to the 8th edition American Joint Committee on Cancer (AJCC) staging system. Evaluation of the TSR was performed on haematoxylin and eosin-stained slides, and correlation with survival outcomes was evaluated. In addition, with the aim of integrating the independent value of the TSR with the 8th edition AJCC staging system, a prognostic nomogram for OTSCC has been developed. OTSCC with a low TSR (i.e. a high proportion of stroma and a low proportion of tumour cells) was shown to have negative prognostic value in terms of disease-specific survival, with a hazard ratio (HR) of 1.883 and a 95% confidence interval (CI) of 1.033-3.432 (P = 0.039), and overall survival (HR = 1.747, 95% CI 0.967-3.154; P = 0.044), independently of other histological and clinical parameters. For the cohort of 139 patients restaged according to the 8th edition AJCC staging system, variables correlating with a poor prognosis were: the TSR, perineural invasion, and sex. The nomogram built on these parameters showed good predictive capacity, outperforming the 8th edition AJCC staging system in stratifying disease-specific survival in OTSCC patients. CONCLUSIONS: Including the TSR in the predictive model could improve risk stratification of OTSCC patients and aid in making treatment decisions.
AIMS: One of the objectives of current research is to customise the treatment of cancerpatients. The achievement of this objective requires stratification of patients based on the most significant prognostic factors. The aims of this study were to evaluate the prognostic value of the tumour-stroma ratio (TSR), defined as the proportion of tumour cells relative to surrounding stroma, in patients with oral tongue squamous cell carcinoma (OTSCC), and to develop a prognostic nomogram based on the most significant clinicopathological features. METHODS AND RESULTS: Clinicopathological data of 211 patients treated at 'Ospedali Riuniti' General Hospital (Ancona, Italy) for OTSCC were collected. One hundred and thirty-nine patients were restaged according to the 8th edition American Joint Committee on Cancer (AJCC) staging system. Evaluation of the TSR was performed on haematoxylin and eosin-stained slides, and correlation with survival outcomes was evaluated. In addition, with the aim of integrating the independent value of the TSR with the 8th edition AJCC staging system, a prognostic nomogram for OTSCC has been developed. OTSCC with a low TSR (i.e. a high proportion of stroma and a low proportion of tumour cells) was shown to have negative prognostic value in terms of disease-specific survival, with a hazard ratio (HR) of 1.883 and a 95% confidence interval (CI) of 1.033-3.432 (P = 0.039), and overall survival (HR = 1.747, 95% CI 0.967-3.154; P = 0.044), independently of other histological and clinical parameters. For the cohort of 139 patients restaged according to the 8th edition AJCC staging system, variables correlating with a poor prognosis were: the TSR, perineural invasion, and sex. The nomogram built on these parameters showed good predictive capacity, outperforming the 8th edition AJCC staging system in stratifying disease-specific survival in OTSCC patients. CONCLUSIONS: Including the TSR in the predictive model could improve risk stratification of OTSCC patients and aid in making treatment decisions.
Authors: Alhadi Almangush; Rasheed Omobolaji Alabi; Giuseppe Troiano; Ricardo D Coletta; Tuula Salo; Matti Pirinen; Antti A Mäkitie; Ilmo Leivo Journal: BMC Cancer Date: 2021-04-30 Impact factor: 4.430
Authors: Lucrezia Togni; Vito Carlo Alberto Caponio; Nicoletta Zerman; Giuseppe Troiano; Khrystyna Zhurakivska; Lorenzo Lo Muzio; Andrea Balercia; Marco Mascitti; Andrea Santarelli Journal: Cancers (Basel) Date: 2022-07-22 Impact factor: 6.575
Authors: Giuseppe Troiano; Corrado Rubini; Lucrezia Togni; Vito Carlo Alberto Caponio; Khrystyna Zhurakivska; Andrea Santarelli; Nicola Cirillo; Lorenzo Lo Muzio; Marco Mascitti Journal: Cancer Med Date: 2020-10-13 Impact factor: 4.452