Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgG1 secretion from anti-Ig-treated B cells.

Literature DB >> 3262706

Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgG1 secretion from anti-Ig-treated B cells.

J M Purkerson¹, M Newberg, G Wise, K R Lynch, P C Isakson.

Abstract

We have analyzed requirements for IL-4-induced secretion of IgG1 from anti-Ig-activated B cells. Activated B cell blasts prepared by culture of high density B cells with anti-Ig failed to secrete IgG1 upon subsequent culture with LPS and IL-4. However, IL-4 markedly suppressed IgM secretion in the same cultures. Addition of a mixture of T cell-derived lymphokines or rIL-5 to LPS-stimulated anti-Ig blasts restored IL-4-stimulated IgG1 secretion; rIL-2 further enhanced the response to IL-4 + rIL-5. These results suggest that IL-4, IL-5, and IL-2 cooperate in the regulation of B lymphocyte Ig isotype expression.

Entities: Gene

Mesh：

Substances：

Year: 1988 PMID： 3262706 PMCID： PMC2189019 DOI： 10.1084/jem.168.3.1175

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

9 in total

1. The role of IL-5 in IgA B cell differentiation.

Authors: G R Harriman; D Y Kunimoto; J F Elliott; V Paetkau; W Strober
Journal: J Immunol Date: 1988-05-01 Impact factor: 5.422

2. Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter.

Authors: Y Noma; P Sideras; T Naito; S Bergstedt-Lindquist; C Azuma; E Severinson; T Tanabe; T Kinashi; F Matsuda; Y Yaoita
Journal: Nature Date: 1986 Feb 20-26 Impact factor: 49.962

3. B cell stimulatory factor-1 (interleukin 4) prepares resting murine B cells to secrete IgG1 upon subsequent stimulation with bacterial lipopolysaccharide.

Authors: C M Snapper; W E Paul
Journal: J Immunol Date: 1987-07-01 Impact factor: 5.422

4. High-efficiency purification and chemical characterization of B cell stimulatory factor-1/interleukin 4.

Authors: J Ohara; J E Coligan; K Zoon; W L Maloy; W E Paul
Journal: J Immunol Date: 1987-08-15 Impact factor: 5.422

5. Phorbol esters inhibit murine B cell differentiation to immunoglobulin secretion but not proliferation.

Authors: P C Isakson; L Simpson
Journal: J Immunol Date: 1984-10 Impact factor: 5.422

6. Antiimmunoglobulin-treated B cells respond to a B cell differentiation factor for IgG1.

Authors: P C Isakson
Journal: J Exp Med Date: 1986-07-01 Impact factor: 14.307

7. Differential regulation of IgG1 and IgE synthesis by interleukin 4.

Authors: C M Snapper; F D Finkelman; W E Paul
Journal: J Exp Med Date: 1988-01-01 Impact factor: 14.307

8. T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

Authors: P C Isakson; E Puré; E S Vitetta; P H Krammer
Journal: J Exp Med Date: 1982-03-01 Impact factor: 14.307

9. T-independent and T-dependent steps in the murine B cell response to antiimmunoglobulin.

Authors: M L Birkeland; L Simpson; P C Isakson; E Pure
Journal: J Exp Med Date: 1987-08-01 Impact factor: 14.307

9 in total

6 in total

5. T-independent and T-dependent B lymphoblasts: helper T cells prime for interleukin 2-induced growth and secretion of immunoglobulins that utilize downstream heavy chains.

Authors: M S Forman; E Puré
Journal: J Exp Med Date: 1991-03-01 Impact factor: 14.307

6. Interleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE.

Authors: J M Purkerson; P C Isakson
Journal: J Exp Med Date: 1992-04-01 Impact factor: 14.307