Literature DB >> 3088197

Antiimmunoglobulin-treated B cells respond to a B cell differentiation factor for IgG1.

P C Isakson.   

Abstract

We have determined whether B cells previously activated by anti-Ig (anti-Ig blasts) are responsive to lymphokines that induce isotype switching. Culture of anti-Ig blasts with a mixture of lymphokines, including BSF-1, resulted in marked secretion of IgM and IgG1, but not other IgG isotypes. The IgG1 response of anti-Ig blasts to lymphokines was 13-fold greater than was observed with splenic B cells. B cell blasts induced by 8-mercaptoguanosine or dextran sulfate did not secrete high levels of any IgG isotype in response to lymphokines alone. An mAb against BSF-1 suppressed the IgG1 response of anti-Ig blasts, but not the IgM response to lymphokines. These data suggest that anti-Ig-treated B cells respond to at least one of the effects of BSF-1.

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Year:  1986        PMID： 3088197      PMCID： PMC2188217          DOI： 10.1084/jem.164.1.303

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  15 in total

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Journal:  J Exp Med       Date:  1983-02-01       Impact factor: 14.307

9.  Interleukin-induced increase in Ia expression by normal mouse B cells.

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10.  T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

Authors:  P C Isakson; E Puré; E S Vitetta; P H Krammer
Journal:  J Exp Med       Date:  1982-03-01       Impact factor: 14.307
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  11 in total

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Authors:  J M Purkerson; P C Isakson
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9.  Differential regulation of IgG1 and IgE synthesis by interleukin 4.

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10.  Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgG1 secretion from anti-Ig-treated B cells.

Authors:  J M Purkerson; M Newberg; G Wise; K R Lynch; P C Isakson
Journal:  J Exp Med       Date:  1988-09-01       Impact factor: 14.307
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