Literature DB >> 32625633

Human and animal dietary exposure to T-2 and HT-2 toxin.

Davide Arcella, Petra Gergelova, Matteo Lorenzo Innocenti, Hans Steinkellner.   

Abstract

T-2 toxin (T2) and HT-2 (HT2) toxin are trichothecenes, which form part of the group of Fusarium mycotoxins. Food and feed samples used to estimate human dietary and animal exposure were reported either as the individual results for T2 and/or, HT2, and/or as the sum of the two. The highest concentrations were reported in oats and oat-containing commodities. Very high levels were reported in a small number of data on specific plant- and herb-based dietary supplements. In humans, the mean chronic dietary exposure to the sum of T2 and HT2 was highest in 'Toddlers' and 'Infants', with maximum upper bound (UB) estimates of 64.8 and 62.9 ng/kg body weight (bw) per day, respectively. The 95th percentile dietary exposure was highest in 'Infants' with a maximum UB estimate of 146 ng/kg bw per day. UB estimations were on average fourfold higher than lower bound (LB) estimations. Average acute exposure ranged from a minimum of 13.4 ng/kg bw per day, estimated in 'Elderly', up to a maximum of 64.7 ng/kg bw per day estimated in 'Toddlers'. The highest 95th percentile acute dietary exposure was estimated for a dietary survey within the age class 'Infants' (170 ng/kg bw per day). Overall, among processed foods the main contributors were cereal flakes, fine bakery wares and, for acute exposure, also bread and rolls. In the elderly and very elderly, dietary supplements made an important contribution. Exposure to the sum of T2 and HT2 in farm and companion animals varied according to the animal species. Exposures considering mean concentration scenarios varied between 0.03-0.08 (LB-UB) μg/kg bw per day in beef cattle and 1.13-1.47 μg/kg bw per day in milking goats. For high concentration scenarios, exposures varied between 0.12-0.16 μg/kg bw per day and 2.37-2.58μg/kg bw per day in the same species. In the absence of data, potential modified form were not included.
© 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

Entities:  

Keywords:  HT‐2; T‐2; dietary exposure; feed; food

Year:  2017        PMID: 32625633      PMCID: PMC7010047          DOI: 10.2903/j.efsa.2017.4972

Source DB:  PubMed          Journal:  EFSA J        ISSN: 1831-4732


  16 in total

1.  Enzyme immunoassays for the detection of mycotoxins in plant-based milk alternatives: pitfalls and limitations.

Authors:  Christina Rehagel; Ronald Maul; Kim Lara Gützkow; Ömer Akineden
Journal:  Mycotoxin Res       Date:  2022-09-02       Impact factor: 4.082

2.  Incentives to Stimulate European Wheat Farmers to Adapt Their Fusarium Species Mycotoxin Management.

Authors:  Esmée M Janssen; Monique C M Mourits; Alfons G J M Oude Lansink; H J van der Fels-Klerx
Journal:  Toxins (Basel)       Date:  2021-02-14       Impact factor: 4.546

3.  A Two-Year Occurrence of Fusarium T-2 and HT-2 Toxin in Croatian Cereals Relative of the Regional Weather.

Authors:  Maja Kiš; Ana Vulić; Nina Kudumija; Bojan Šarkanj; Vesna Jaki Tkalec; Krunoslav Aladić; Mario Škrivanko; Sanja Furmeg; Jelka Pleadin
Journal:  Toxins (Basel)       Date:  2021-01-07       Impact factor: 4.546

Review 4.  Trichothecenes in Food and Feed, Relevance to Human and Animal Health and Methods of Detection: A Systematic Review.

Authors:  Magdalena Polak-Śliwińska; Beata Paszczyk
Journal:  Molecules       Date:  2021-01-16       Impact factor: 4.411

5.  Multiple Mycotoxins in Kenyan Rice.

Authors:  Samuel K Mutiga; J Musembi Mutuku; Vincent Koskei; James Kamau Gitau; Fredrick Ng'ang'a; Joyce Musyoka; George N Chemining'wa; Rosemary Murori
Journal:  Toxins (Basel)       Date:  2021-03-11       Impact factor: 4.546

6.  Determination of Zearalenone and Trichothecenes, Including Deoxynivalenol and Its Acetylated Derivatives, Nivalenol, T-2 and HT-2 Toxins, in Wheat and Wheat Products by LC-MS/MS: A Collaborative Study.

Authors:  Annalisa De Girolamo; Biancamaria Ciasca; Michelangelo Pascale; Veronica M T Lattanzio
Journal:  Toxins (Basel)       Date:  2020-12-10       Impact factor: 4.546

Review 7.  Presence of Mycotoxins in Milk Thistle (Silybum marianum) Food Supplements: A Review.

Authors:  Darina Pickova; Vladimir Ostry; Jakub Toman; Frantisek Malir
Journal:  Toxins (Basel)       Date:  2020-12-08       Impact factor: 4.546

Review 8.  Mycotoxins in Pistachios (Pistacia vera L.): Methods for Determination, Occurrence, Decontamination.

Authors:  Ana Rita Soares Mateus; Sílvia Barros; Angelina Pena; Ana Sanches Silva
Journal:  Toxins (Basel)       Date:  2021-09-25       Impact factor: 4.546

9.  Distribution of T-2 toxin and HT-2 toxin during experimental feeding of yellow mealworm (Tenebrio molitor).

Authors:  Nicolo Piacenza; Florian Kaltner; Ronald Maul; Manfred Gareis; Karin Schwaiger; Christoph Gottschalk
Journal:  Mycotoxin Res       Date:  2020-09-29       Impact factor: 3.833

10.  Human Biomonitoring of T-2 Toxin, T-2 Toxin-3-Glucoside and Their Metabolites in Urine through High-Resolution Mass Spectrometry.

Authors:  Alfonso Narváez; Luana Izzo; Noelia Pallarés; Luigi Castaldo; Yelko Rodríguez-Carrasco; Alberto Ritieni
Journal:  Toxins (Basel)       Date:  2021-12-05       Impact factor: 4.546

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