Literature DB >> 32606377

Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder.

Scott C Fears1,2,3, Susan K Service4,5, Barbara Kremeyer6, Carmen Araya7, Xinia Araya7, Julio Bejarano7, Margarita Ramirez7, Gabriel Castrillón8, Juliana Gomez-Franco9, Maria C Lopez10, Gabriel Montoya10, Patricia Montoya10, Ileana Aldana4, Terri M Teshiba4, Noor B Al-Sharif4, Maria Jalbrzikowski4, Todd A Tishler4, Javier Escobar11, Andrés Ruiz-Linares12,13,14, Carlos Lopez-Jaramillo10, Gabriel Macaya7, Julio Molina4,15, Victor I Reus16, Rita M Cantor4,17, Chiara Sabatti18, Nelson B Freimer4,5, Carrie E Bearden4,5.   

Abstract

Bipolar disorder is a highly heritable illness, associated with alterations of brain structure. As such, identification of genes influencing inter-individual differences in brain morphology may help elucidate the underlying pathophysiology of bipolar disorder (BP). To identify quantitative trait loci (QTL) that contribute to phenotypic variance of brain structure, structural neuroimages were acquired from family members (n = 527) of extended pedigrees heavily loaded for bipolar disorder ascertained from genetically isolated populations in Latin America. Genome-wide linkage and association analysis were conducted on the subset of heritable brain traits that showed significant evidence of association with bipolar disorder (n = 24) to map QTL influencing regional measures of brain volume and cortical thickness. Two chromosomal regions showed significant evidence of linkage; a QTL on chromosome 1p influencing corpus callosum volume and a region on chromosome 7p linked to cortical volume. Association analysis within the two QTLs identified three SNPs correlated with the brain measures.
© 2020. The Author(s), under exclusive licence to Springer Nature Limited.

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Year:  2020        PMID： 32606377     DOI： 10.1038/s41380-020-0805-6

Source DB:  PubMed          Journal:  Mol Psychiatry        ISSN： 1359-4184            Impact factor:   15.992


  37 in total

Review 1.  Family-based designs for genome-wide association studies.

Authors:  Jurg Ott; Yoichiro Kamatani; Mark Lathrop
Journal:  Nat Rev Genet       Date:  2011-06-01       Impact factor: 53.242

Review 2.  Cortical thickness in bipolar disorder: a systematic review.

Authors:  Lindsay C Hanford; Anthony Nazarov; Geoffrey B Hall; Roberto B Sassi
Journal:  Bipolar Disord       Date:  2016-02-06       Impact factor: 6.744

3.  Heritability of white matter microstructure in late middle age: A twin study of tract-based fractional anisotropy and absolute diffusivity indices.

Authors:  Eero Vuoksimaa; Matthew S Panizzon; Donald J Hagler; Sean N Hatton; Christine Fennema-Notestine; Daniel Rinker; Lisa T Eyler; Carol E Franz; Michael J Lyons; Michael C Neale; Ming T Tsuang; Anders M Dale; William S Kremen
Journal:  Hum Brain Mapp       Date:  2016-12-29       Impact factor: 5.038

4.  The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013.

Authors:  Alize J Ferrari; Emily Stockings; Jon-Paul Khoo; Holly E Erskine; Louisa Degenhardt; Theo Vos; Harvey A Whiteford
Journal:  Bipolar Disord       Date:  2016-08       Impact factor: 6.744

Review 5.  Genetic influences on human brain structure: a review of brain imaging studies in twins.

Authors:  Jiska S Peper; Rachel M Brouwer; Dorret I Boomsma; René S Kahn; Hilleke E Hulshoff Pol
Journal:  Hum Brain Mapp       Date:  2007-06       Impact factor: 5.038

6.  Identification of common variants associated with human hippocampal and intracranial volumes.

Authors:  Jason L Stein; Sarah E Medland; Alejandro Arias Vasquez; Derrek P Hibar; Rudy E Senstad; Anderson M Winkler; Roberto Toro; Katja Appel; Richard Bartecek; Ørjan Bergmann; Manon Bernard; Andrew A Brown; Dara M Cannon; M Mallar Chakravarty; Andrea Christoforou; Martin Domin; Oliver Grimm; Marisa Hollinshead; Avram J Holmes; Georg Homuth; Jouke-Jan Hottenga; Camilla Langan; Lorna M Lopez; Narelle K Hansell; Kristy S Hwang; Sungeun Kim; Gonzalo Laje; Phil H Lee; Xinmin Liu; Eva Loth; Anbarasu Lourdusamy; Morten Mattingsdal; Sebastian Mohnke; Susana Muñoz Maniega; Kwangsik Nho; Allison C Nugent; Carol O'Brien; Martina Papmeyer; Benno Pütz; Adaikalavan Ramasamy; Jerod Rasmussen; Mark Rijpkema; Shannon L Risacher; J Cooper Roddey; Emma J Rose; Mina Ryten; Li Shen; Emma Sprooten; Eric Strengman; Alexander Teumer; Daniah Trabzuni; Jessica Turner; Kristel van Eijk; Theo G M van Erp; Marie-Jose van Tol; Katharina Wittfeld; Christiane Wolf; Saskia Woudstra; Andre Aleman; Saud Alhusaini; Laura Almasy; Elisabeth B Binder; David G Brohawn; Rita M Cantor; Melanie A Carless; Aiden Corvin; Michael Czisch; Joanne E Curran; Gail Davies; Marcio A A de Almeida; Norman Delanty; Chantal Depondt; Ravi Duggirala; Thomas D Dyer; Susanne Erk; Jesen Fagerness; Peter T Fox; Nelson B Freimer; Michael Gill; Harald H H Göring; Donald J Hagler; David Hoehn; Florian Holsboer; Martine Hoogman; Norbert Hosten; Neda Jahanshad; Matthew P Johnson; Dalia Kasperaviciute; Jack W Kent; Peter Kochunov; Jack L Lancaster; Stephen M Lawrie; David C Liewald; René Mandl; Mar Matarin; Manuel Mattheisen; Eva Meisenzahl; Ingrid Melle; Eric K Moses; Thomas W Mühleisen; Matthias Nauck; Markus M Nöthen; Rene L Olvera; Massimo Pandolfo; G Bruce Pike; Ralf Puls; Ivar Reinvang; Miguel E Rentería; Marcella Rietschel; Joshua L Roffman; Natalie A Royle; Dan Rujescu; Jonathan Savitz; Hugo G Schnack; Knut Schnell; Nina Seiferth; Colin Smith; Vidar M Steen; Maria C Valdés Hernández; Martijn Van den Heuvel; Nic J van der Wee; Neeltje E M Van Haren; Joris A Veltman; Henry Völzke; Robert Walker; Lars T Westlye; Christopher D Whelan; Ingrid Agartz; Dorret I Boomsma; Gianpiero L Cavalleri; Anders M Dale; Srdjan Djurovic; Wayne C Drevets; Peter Hagoort; Jeremy Hall; Andreas Heinz; Clifford R Jack; Tatiana M Foroud; Stephanie Le Hellard; Fabio Macciardi; Grant W Montgomery; Jean Baptiste Poline; David J Porteous; Sanjay M Sisodiya; John M Starr; Jessika Sussmann; Arthur W Toga; Dick J Veltman; Henrik Walter; Michael W Weiner; Joshua C Bis; M Arfan Ikram; Albert V Smith; Vilmundur Gudnason; Christophe Tzourio; Meike W Vernooij; Lenore J Launer; Charles DeCarli; Sudha Seshadri; Ole A Andreassen; Liana G Apostolova; Mark E Bastin; John Blangero; Han G Brunner; Randy L Buckner; Sven Cichon; Giovanni Coppola; Greig I de Zubicaray; Ian J Deary; Gary Donohoe; Eco J C de Geus; Thomas Espeseth; Guillén Fernández; David C Glahn; Hans J Grabe; John Hardy; Hilleke E Hulshoff Pol; Mark Jenkinson; René S Kahn; Colm McDonald; Andrew M McIntosh; Francis J McMahon; Katie L McMahon; Andreas Meyer-Lindenberg; Derek W Morris; Bertram Müller-Myhsok; Thomas E Nichols; Roel A Ophoff; Tomas Paus; Zdenka Pausova; Brenda W Penninx; Steven G Potkin; Philipp G Sämann; Andrew J Saykin; Gunter Schumann; Jordan W Smoller; Joanna M Wardlaw; Michael E Weale; Nicholas G Martin; Barbara Franke; Margaret J Wright; Paul M Thompson
Journal:  Nat Genet       Date:  2012-04-15       Impact factor: 38.330

7.  Common genetic variants influence human subcortical brain structures.

Authors:  Derrek P Hibar; Jason L Stein; Miguel E Renteria; Alejandro Arias-Vasquez; Sylvane Desrivières; Neda Jahanshad; Roberto Toro; Katharina Wittfeld; Lucija Abramovic; Micael Andersson; Benjamin S Aribisala; Nicola J Armstrong; Manon Bernard; Marc M Bohlken; Marco P Boks; Janita Bralten; Andrew A Brown; M Mallar Chakravarty; Qiang Chen; Christopher R K Ching; Gabriel Cuellar-Partida; Anouk den Braber; Sudheer Giddaluru; Aaron L Goldman; Oliver Grimm; Tulio Guadalupe; Johanna Hass; Girma Woldehawariat; Avram J Holmes; Martine Hoogman; Deborah Janowitz; Tianye Jia; Sungeun Kim; Marieke Klein; Bernd Kraemer; Phil H Lee; Loes M Olde Loohuis; Michelle Luciano; Christine Macare; Karen A Mather; Manuel Mattheisen; Yuri Milaneschi; Kwangsik Nho; Martina Papmeyer; Adaikalavan Ramasamy; Shannon L Risacher; Roberto Roiz-Santiañez; Emma J Rose; Alireza Salami; Philipp G Sämann; Lianne Schmaal; Andrew J Schork; Jean Shin; Lachlan T Strike; Alexander Teumer; Marjolein M J van Donkelaar; Kristel R van Eijk; Raymond K Walters; Lars T Westlye; Christopher D Whelan; Anderson M Winkler; Marcel P Zwiers; Saud Alhusaini; Lavinia Athanasiu; Stefan Ehrlich; Marina M H Hakobjan; Cecilie B Hartberg; Unn K Haukvik; Angelien J G A M Heister; David Hoehn; Dalia Kasperaviciute; David C M Liewald; Lorna M Lopez; Remco R R Makkinje; Mar Matarin; Marlies A M Naber; D Reese McKay; Margaret Needham; Allison C Nugent; Benno Pütz; Natalie A Royle; Li Shen; Emma Sprooten; Daniah Trabzuni; Saskia S L van der Marel; Kimm J E van Hulzen; Esther Walton; Christiane Wolf; Laura Almasy; David Ames; Sampath Arepalli; Amelia A Assareh; Mark E Bastin; Henry Brodaty; Kazima B Bulayeva; Melanie A Carless; Sven Cichon; Aiden Corvin; Joanne E Curran; Michael Czisch; Greig I de Zubicaray; Allissa Dillman; Ravi Duggirala; Thomas D Dyer; Susanne Erk; Iryna O Fedko; Luigi Ferrucci; Tatiana M Foroud; Peter T Fox; Masaki Fukunaga; J Raphael Gibbs; Harald H H Göring; Robert C Green; Sebastian Guelfi; Narelle K Hansell; Catharina A Hartman; Katrin Hegenscheid; Andreas Heinz; Dena G Hernandez; Dirk J Heslenfeld; Pieter J Hoekstra; Florian Holsboer; Georg Homuth; Jouke-Jan Hottenga; Masashi Ikeda; Clifford R Jack; Mark Jenkinson; Robert Johnson; Ryota Kanai; Maria Keil; Jack W Kent; Peter Kochunov; John B Kwok; Stephen M Lawrie; Xinmin Liu; Dan L Longo; Katie L McMahon; Eva Meisenzahl; Ingrid Melle; Sebastian Mohnke; Grant W Montgomery; Jeanette C Mostert; Thomas W Mühleisen; Michael A Nalls; Thomas E Nichols; Lars G Nilsson; Markus M Nöthen; Kazutaka Ohi; Rene L Olvera; Rocio Perez-Iglesias; G Bruce Pike; Steven G Potkin; Ivar Reinvang; Simone Reppermund; Marcella Rietschel; Nina Romanczuk-Seiferth; Glenn D Rosen; Dan Rujescu; Knut Schnell; Peter R Schofield; Colin Smith; Vidar M Steen; Jessika E Sussmann; Anbupalam Thalamuthu; Arthur W Toga; Bryan J Traynor; Juan Troncoso; Jessica A Turner; Maria C Valdés Hernández; Dennis van 't Ent; Marcel van der Brug; Nic J A van der Wee; Marie-Jose van Tol; Dick J Veltman; Thomas H Wassink; Eric Westman; Ronald H Zielke; Alan B Zonderman; David G Ashbrook; Reinmar Hager; Lu Lu; Francis J McMahon; Derek W Morris; Robert W Williams; Han G Brunner; Randy L Buckner; Jan K Buitelaar; Wiepke Cahn; Vince D Calhoun; Gianpiero L Cavalleri; Benedicto Crespo-Facorro; Anders M Dale; Gareth E Davies; Norman Delanty; Chantal Depondt; Srdjan Djurovic; Wayne C Drevets; Thomas Espeseth; Randy L Gollub; Beng-Choon Ho; Wolfgang Hoffmann; Norbert Hosten; René S Kahn; Stephanie Le Hellard; Andreas Meyer-Lindenberg; Bertram Müller-Myhsok; Matthias Nauck; Lars Nyberg; Massimo Pandolfo; Brenda W J H Penninx; Joshua L Roffman; Sanjay M Sisodiya; Jordan W Smoller; Hans van Bokhoven; Neeltje E M van Haren; Henry Völzke; Henrik Walter; Michael W Weiner; Wei Wen; Tonya White; Ingrid Agartz; Ole A Andreassen; John Blangero; Dorret I Boomsma; Rachel M Brouwer; Dara M Cannon; Mark R Cookson; Eco J C de Geus; Ian J Deary; Gary Donohoe; Guillén Fernández; Simon E Fisher; Clyde Francks; David C Glahn; Hans J Grabe; Oliver Gruber; John Hardy; Ryota Hashimoto; Hilleke E Hulshoff Pol; Erik G Jönsson; Iwona Kloszewska; Simon Lovestone; Venkata S Mattay; Patrizia Mecocci; Colm McDonald; Andrew M McIntosh; Roel A Ophoff; Tomas Paus; Zdenka Pausova; Mina Ryten; Perminder S Sachdev; Andrew J Saykin; Andy Simmons; Andrew Singleton; Hilkka Soininen; Joanna M Wardlaw; Michael E Weale; Daniel R Weinberger; Hieab H H Adams; Lenore J Launer; Stephan Seiler; Reinhold Schmidt; Ganesh Chauhan; Claudia L Satizabal; James T Becker; Lisa Yanek; Sven J van der Lee; Maritza Ebling; Bruce Fischl; W T Longstreth; Douglas Greve; Helena Schmidt; Paul Nyquist; Louis N Vinke; Cornelia M van Duijn; Luting Xue; Bernard Mazoyer; Joshua C Bis; Vilmundur Gudnason; Sudha Seshadri; M Arfan Ikram; Nicholas G Martin; Margaret J Wright; Gunter Schumann; Barbara Franke; Paul M Thompson; Sarah E Medland
Journal:  Nature       Date:  2015-01-21       Impact factor: 49.962

8.  Common variants at 12q14 and 12q24 are associated with hippocampal volume.

Authors:  Joshua C Bis; Charles DeCarli; Albert Vernon Smith; Fedde van der Lijn; Fabrice Crivello; Myriam Fornage; Stephanie Debette; Joshua M Shulman; Helena Schmidt; Velandai Srikanth; Maaike Schuur; Lei Yu; Seung-Hoan Choi; Sigurdur Sigurdsson; Benjamin F J Verhaaren; Anita L DeStefano; Jean-Charles Lambert; Clifford R Jack; Maksim Struchalin; Jim Stankovich; Carla A Ibrahim-Verbaas; Debra Fleischman; Alex Zijdenbos; Tom den Heijer; Bernard Mazoyer; Laura H Coker; Christian Enzinger; Patrick Danoy; Najaf Amin; Konstantinos Arfanakis; Mark A van Buchem; Renée F A G de Bruijn; Alexa Beiser; Carole Dufouil; Juebin Huang; Margherita Cavalieri; Russell Thomson; Wiro J Niessen; Lori B Chibnik; Gauti K Gislason; Albert Hofman; Aleksandra Pikula; Philippe Amouyel; Kevin B Freeman; Thanh G Phan; Ben A Oostra; Jason L Stein; Sarah E Medland; Alejandro Arias Vasquez; Derrek P Hibar; Margaret J Wright; Barbara Franke; Nicholas G Martin; Paul M Thompson; Michael A Nalls; Andre G Uitterlinden; Rhoda Au; Alexis Elbaz; Richard J Beare; John C van Swieten; Oscar L Lopez; Tamara B Harris; Vincent Chouraki; Monique M B Breteler; Philip L De Jager; James T Becker; Meike W Vernooij; David Knopman; Franz Fazekas; Philip A Wolf; Aad van der Lugt; Vilmundur Gudnason; W T Longstreth; Matthew A Brown; David A Bennett; Cornelia M van Duijn; Thomas H Mosley; Reinhold Schmidt; Christophe Tzourio; Lenore J Launer; M Arfan Ikram; Sudha Seshadri
Journal:  Nat Genet       Date:  2012-04-15       Impact factor: 38.330

9.  Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.

Authors:  D P Hibar; L T Westlye; N T Doan; N Jahanshad; J W Cheung; C R K Ching; A Versace; A C Bilderbeck; A Uhlmann; B Mwangi; B Krämer; B Overs; C B Hartberg; C Abé; D Dima; D Grotegerd; E Sprooten; E Bøen; E Jimenez; F M Howells; G Delvecchio; H Temmingh; J Starke; J R C Almeida; J M Goikolea; J Houenou; L M Beard; L Rauer; L Abramovic; M Bonnin; M F Ponteduro; M Keil; M M Rive; N Yao; N Yalin; P Najt; P G Rosa; R Redlich; S Trost; S Hagenaars; S C Fears; S Alonso-Lana; T G M van Erp; T Nickson; T M Chaim-Avancini; T B Meier; T Elvsåshagen; U K Haukvik; W H Lee; A H Schene; A J Lloyd; A H Young; A Nugent; A M Dale; A Pfennig; A M McIntosh; B Lafer; B T Baune; C J Ekman; C A Zarate; C E Bearden; C Henry; C Simhandl; C McDonald; C Bourne; D J Stein; D H Wolf; D M Cannon; D C Glahn; D J Veltman; E Pomarol-Clotet; E Vieta; E J Canales-Rodriguez; F G Nery; F L S Duran; G F Busatto; G Roberts; G D Pearlson; G M Goodwin; H Kugel; H C Whalley; H G Ruhe; J C Soares; J M Fullerton; J K Rybakowski; J Savitz; K T Chaim; M Fatjó-Vilas; M G Soeiro-de-Souza; M P Boks; M V Zanetti; M C G Otaduy; M S Schaufelberger; M Alda; M Ingvar; M L Phillips; M J Kempton; M Bauer; M Landén; N S Lawrence; N E M van Haren; N R Horn; N B Freimer; O Gruber; P R Schofield; P B Mitchell; R S Kahn; R Lenroot; R Machado-Vieira; R A Ophoff; S Sarró; S Frangou; T D Satterthwaite; T Hajek; U Dannlowski; U F Malt; V Arolt; W F Gattaz; W C Drevets; X Caseras; I Agartz; P M Thompson; O A Andreassen
Journal:  Mol Psychiatry       Date:  2017-05-02       Impact factor: 15.992

Review 10.  Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease.

Authors:  Jonathan Flint; Nicholas Timpson; Marcus Munafò
Journal:  Trends Neurosci       Date:  2014-09-09       Impact factor: 13.837
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  1 in total

1.  Exploring the Effects of Temperament on Gray Matter Volume of Frontal Cortex in Patients with Mood Disorders.

Authors:  Tao Yang; Raymond W Lam; Jia Huang; Yousong Su; Jing Liu; Xiaorui Yang; Lu Yang; Na Zhu; Guoqing Zhao; Ruizhi Mao; Rubai Zhou; Weiping Xia; Hongmei Liu; Zuowei Wang; Jun Chen; Yiru Fang
Journal:  Neuropsychiatr Dis Treat       Date:  2021-01-22       Impact factor: 2.570
  1 in total

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