Literature DB >> 3260464

Effects of spinal cord stimulation on spasticity and spasms secondary to myelopathy.

G Barolat1, J B Myklebust, W Wenninger.   

Abstract

16 subjects with severe spasms secondary to traumatic and nontraumatic myelopathy underwent epidural spinal cord stimulation. 4 patients had a complete motor and sensory spinal cord lesion. 6 of the subjects with an incomplete spinal cord lesion were ambulatory. All patients had previously undergone extensive trials with medications and physical therapy. All 14 subjects in whom a satisfactory placement of the electrode could be obtained had a reduction in the severity of the spasms. In 6 patients, the spasms were almost abolished. Extremity, trunkal and abdominal spasms were affected. Clonus in the upper extremities was consistently reduced. Marked improvement in bladder and bowel function was observed in each of 2 subjects. In over 1-year follow-up, 5 subjects show persistence of the results, with less stimulation required to maintain the therapeutic effects. No neurological deterioration occurred following the procedure or after long-term spinal stimulation. 1 patient showed after several months of continuous stimulation increased voluntary motor control present only when spinal cord stimulation was activated. Complications included 1 system infection, 1 electrode migration, 1 wire breakage and skin breakdown at a connector site, development of high impedance in 1 electrode and 1 skin breakdown over the lead.

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Year:  1988        PMID: 3260464     DOI: 10.1159/000099381

Source DB:  PubMed          Journal:  Appl Neurophysiol


  7 in total

1.  Modification of spasticity by transcutaneous spinal cord stimulation in individuals with incomplete spinal cord injury.

Authors:  Ursula S Hofstoetter; William B McKay; Keith E Tansey; Winfried Mayr; Helmut Kern; Karen Minassian
Journal:  J Spinal Cord Med       Date:  2013-11-26       Impact factor: 1.985

Review 2.  Understanding Early-Stage Posttraumatic Osteoarthritis for Future Prospects of Diagnosis: from Knee to Temporomandibular Joint.

Authors:  Fazal-Ur-Rehman Bhatti; Anastasios Karydis; Beth S Lee; Toru Deguchi; Do-Gyoon Kim; Hongsik Cho
Journal:  Curr Osteoporos Rep       Date:  2021-02-01       Impact factor: 5.096

Review 3.  Neuromodulation of lower limb motor control in restorative neurology.

Authors:  Karen Minassian; Ursula Hofstoetter; Keith Tansey; Winfried Mayr
Journal:  Clin Neurol Neurosurg       Date:  2012-03-29       Impact factor: 1.876

4.  Long-Term Spinal Cord Stimulation After Chronic Complete Spinal Cord Injury Enables Volitional Movement in the Absence of Stimulation.

Authors:  Isabela Peña Pino; Caleb Hoover; Shivani Venkatesh; Aliya Ahmadi; Dylan Sturtevant; Nick Patrick; David Freeman; Ann Parr; Uzma Samadani; David Balser; Andrei Krassioukov; Aaron Phillips; Theoden I Netoff; David Darrow
Journal:  Front Syst Neurosci       Date:  2020-06-30

5.  Single Lead Epidural Spinal Cord Stimulation Targeted Trunk Control and Standing in Complete Paraplegia.

Authors:  Ashraf S Gorgey; Jan J Gouda
Journal:  J Clin Med       Date:  2022-08-30       Impact factor: 4.964

Review 6.  Targeting Lumbar Spinal Neural Circuitry by Epidural Stimulation to Restore Motor Function After Spinal Cord Injury.

Authors:  Karen Minassian; W Barry McKay; Heinrich Binder; Ursula S Hofstoetter
Journal:  Neurotherapeutics       Date:  2016-04       Impact factor: 7.620

7.  Epidural Electrical Stimulation: A Review of Plasticity Mechanisms That Are Hypothesized to Underlie Enhanced Recovery From Spinal Cord Injury With Stimulation.

Authors:  Jaclyn T Eisdorfer; Rupert D Smit; Kathleen M Keefe; Michel A Lemay; George M Smith; Andrew J Spence
Journal:  Front Mol Neurosci       Date:  2020-09-02       Impact factor: 5.639

  7 in total

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