Fazal-Ur-Rehman Bhatti1, Anastasios Karydis1, Beth S Lee2, Toru Deguchi3, Do-Gyoon Kim4, Hongsik Cho5,6,7. 1. Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Research 151, VAMC, 1030 Jefferson Ave, Memphis, TN, 38104 , USA. 2. Department of Physiology and Cell Biology, College of Medicine, The Ohio State University , Graves Hall, 333 West 10th Avenue, Columbus, OH, 43210, USA. 3. Division of Orthodontics, College of Dentistry, The Ohio State University, 4088 Postle Hall, 305 W. 12th Ave., Columbus, OH, 43210, USA. 4. Division of Orthodontics, College of Dentistry, The Ohio State University, 4088 Postle Hall, 305 W. 12th Ave., Columbus, OH, 43210, USA. kim.2508@osu.edu. 5. Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Research 151, VAMC, 1030 Jefferson Ave, Memphis, TN, 38104 , USA. hcho4@uthsc.edu. 6. Campbell Clinic, Memphis, TN, USA. hcho4@uthsc.edu. 7. Veterans Affairs Medical Center, Memphis, TN, USA. hcho4@uthsc.edu.
Abstract
PURPOSE OF REVIEW: Many mechanical load-bearing joints of the body are prone to posttraumatic osteoarthritis (PTOA), including the knee joint and temporomandibular joint (TMJ). Early detection of PTOA can be beneficial in prevention or alleviating further progression of the disease. RECENT FINDINGS: Various mouse models, similar to those used in development of novel diagnosis strategies for early stages of OA, have been proposed to study early PTOA. While many studies have focused on OA and PTOA in the knee joint, early diagnostic methods for OA and PTOA of the TMJ are still not well established. Previously, we showed that fluorescent near-infrared imaging can diagnose inflammation and cartilage damage in mouse models of knee PTOA. Here we propose that the same approach can be used for early diagnosis of TMJ-PTOA. In this review, we present a brief overview of PTOA, application of relevant mouse models, current imaging methods available to examine TMJ-PTOA, and the prospects of near-infrared optical imaging to diagnose early-stage TMJ-OA.
PURPOSE OF REVIEW: Many mechanical load-bearing joints of the body are prone to posttraumatic osteoarthritis (PTOA), including the knee joint and temporomandibular joint (TMJ). Early detection of PTOA can be beneficial in prevention or alleviating further progression of the disease. RECENT FINDINGS: Various mouse models, similar to those used in development of novel diagnosis strategies for early stages of OA, have been proposed to study early PTOA. While many studies have focused on OA and PTOA in the knee joint, early diagnostic methods for OA and PTOA of the TMJ are still not well established. Previously, we showed that fluorescent near-infrared imaging can diagnose inflammation and cartilage damage in mouse models of knee PTOA. Here we propose that the same approach can be used for early diagnosis of TMJ-PTOA. In this review, we present a brief overview of PTOA, application of relevant mouse models, current imaging methods available to examine TMJ-PTOA, and the prospects of near-infrared optical imaging to diagnose early-stage TMJ-OA.
Authors: Do-Gyoon Kim; Arman Haghighi; Hyun-Jung Kwon; Jessica S Coogan; Daniel P Nicolella; Trenton B Johnson; Hwan D Kim; Nari Kim; Amanda M Agnew Journal: J Mech Behav Biomed Mater Date: 2017-03-16
Authors: Do-Gyoon Kim; Yong-Hoon Jeong; Erin Kosel; Amanda M Agnew; David W McComb; Kyle Bodnyk; Richard T Hart; Min Kyung Kim; Sang Yeun Han; William M Johnston Journal: Bone Date: 2015-04-22 Impact factor: 4.398