Literature DB >> 326034

Adrenocorticosteroid therapy in alcoholic hepatitis. A prospective, double-blind randomized study.

B L Blitzer, M G Mutchnick, P H Joshi, M M Phillips, J M Fessel, H O Conn.   

Abstract

In a prospective, randomized, double-blind study of prednisolone therapy of acute alcoholic hepatitis, 39% of the total group of 28 patients died. Mortality and cumulative survival were similar in steroid- and placebo-treated patients. After 14 days of therapy, the serum albumin concentration and white blood count were significantly higher in the steroid group, but all other parameters were similar. An increased risk of fungal infection appeared to be associated with steroid therapy.

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Year:  1977        PMID: 326034     DOI: 10.1007/BF01072499

Source DB:  PubMed          Journal:  Am J Dig Dis        ISSN: 0002-9211


  13 in total

1.  Treatment of alcoholic hepatitis with encephalopathy. Comparison of prednisolone with caloric supplements.

Authors:  H R Lesesne; E M Bozymski; H J Fallon
Journal:  Gastroenterology       Date:  1978-02       Impact factor: 22.682

2.  Adrenocorticosteroid therapy in alcoholic hepatitis. A prospective, double-blind randomized study.

Authors:  B L Blitzer; M G Mutchnick; P H Joshi; M M Phillips; J M Fessel; H O Conn
Journal:  Am J Dig Dis       Date:  1977-06

3.  Sex, ascites and alcoholism in survival of patients with cirrhosis. Effect of prednisone.

Authors: 
Journal:  N Engl J Med       Date:  1974-08-08       Impact factor: 91.245

4.  Corticosteroid therapy in severe alcoholic hepatitis. A double-blind drug trial.

Authors:  H P Porter; F R Simon; C E Pope; W Volwiler; L F Fenster
Journal:  N Engl J Med       Date:  1971-06-17       Impact factor: 91.245

5.  Alcoholic hepatitis. Natural history and evaluation of prednisolone therapy.

Authors:  R A Helman; M H Temko; S W Nye; H J Fallon
Journal:  Ann Intern Med       Date:  1971-03       Impact factor: 25.391

6.  Prednisone therapy of acute alcoholic hepatitis. Report of a controlled trial.

Authors:  J L Campra; E M Hamlin; R J Kirshbaum; M Olivier; A G Redeker; T B Reynolds
Journal:  Ann Intern Med       Date:  1973-11       Impact factor: 25.391

7.  The clinical-pathologic spectrum of alcoholic hepatitis.

Authors:  D H Gregory; D F Levi
Journal:  Am J Dig Dis       Date:  1972-06

8.  Natural history of alcoholic hepatitis. I. The acute disease.

Authors:  M W Lischner; J F Alexander; J T Galambos
Journal:  Am J Dig Dis       Date:  1971-06

Review 9.  Steatonecrosis--Mallory body type.

Authors:  U Harinasuta; B Chomet; K Ishak; H J Zimmerman
Journal:  Medicine (Baltimore)       Date:  1967-03       Impact factor: 1.889

10.  Alcoholic hepatitis superimposed on cirrhosis. Clinical significance and effect of long-term prednisone treatment.

Authors:  P Schlichting; E Juhl; H Poulsen; P Winkel
Journal:  Scand J Gastroenterol       Date:  1976       Impact factor: 2.423

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  23 in total

1.  Corticosteroids and pentoxifylline for the treatment of alcoholic hepatitis: Current status.

Authors:  Ashwani K Singal; Ishmeet Walia; Anjna Singal; Roger D Soloway
Journal:  World J Hepatol       Date:  2011-08-27

Review 2.  Interaction of alcohol with other drugs and nutrients. Implication for the therapy of alcoholic liver disease.

Authors:  C S Lieber
Journal:  Drugs       Date:  1990       Impact factor: 9.546

Review 3.  Early mortality of alcoholic hepatitis: a review of data from placebo-controlled clinical trials.

Authors:  Chao-Hui Yu; Cheng-Fu Xu; Hua Ye; Lan Li; You-Ming Li
Journal:  World J Gastroenterol       Date:  2010-05-21       Impact factor: 5.742

Review 4.  Therapy for alcoholic liver disease.

Authors:  Maryconi M Jaurigue; Mitchell S Cappell
Journal:  World J Gastroenterol       Date:  2014-03-07       Impact factor: 5.742

5.  Adrenocorticosteroid therapy in alcoholic hepatitis. A prospective, double-blind randomized study.

Authors:  B L Blitzer; M G Mutchnick; P H Joshi; M M Phillips; J M Fessel; H O Conn
Journal:  Am J Dig Dis       Date:  1977-06

Review 6.  Corticosteroids in liver disease: possible mechanisms of action, pharmacology, and rational use.

Authors:  A R Tanner; L W Powell
Journal:  Gut       Date:  1979-12       Impact factor: 23.059

Review 7.  Pharmacological interventions for alcoholic liver disease (alcohol-related liver disease): an attempted network meta-analysis.

Authors:  Elena Buzzetti; Maria Kalafateli; Douglas Thorburn; Brian R Davidson; Maja Thiele; Lise Lotte Gluud; Cinzia Del Giovane; Gro Askgaard; Aleksander Krag; Emmanuel Tsochatzis; Kurinchi Selvan Gurusamy
Journal:  Cochrane Database Syst Rev       Date:  2017-03-31

Review 8.  Advances in alcoholic liver disease: An update on alcoholic hepatitis.

Authors:  Randy Liang; Andy Liu; Ryan B Perumpail; Robert J Wong; Aijaz Ahmed
Journal:  World J Gastroenterol       Date:  2015-11-14       Impact factor: 5.742

9.  Depressed delayed cutaneous hypersensitivity in alcoholic hepatitis.

Authors:  N Snyder; J Bessoff; J M Dwyer; H O Conn
Journal:  Am J Dig Dis       Date:  1978-04

10.  Management of alcoholic hepatitis: Current concepts.

Authors:  Hetal A Karsan; Samir Parekh
Journal:  World J Hepatol       Date:  2012-12-27
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