Literature DB >> 3260190

The rat anococcygeus muscle is a convenient bioassay organ for the airway epithelium-derived relaxant factor.

M O Güc1, M Ilhan, S O Kayaalp.   

Abstract

The response to epithelium-derived relaxant factor (EpDRF) released from guinea-pig trachea by acetylcholine was studied in the precontracted rat anococcygeus muscle in a coaxial bioassay system. Acetylcholine caused no relaxation of rat anococcygeus muscle which was precontracted with phenylephrine. When the same muscle was placed into a guinea-pig trachea with intact epithelium, acetylcholine produced a slowly developing relaxation which was potentiated by neostigmine and antagonized by atropine but was not altered by indomethacin, propranolol, hydroquinone nor methylene blue. The rat anococcygeus muscle was not relaxed by acetylcholine when it was placed in an epithelium-free trachea. The results indicate that acetylcholine releases EpDRF from guinea-pig trachea and that rat anococcygeus muscle is a convenient organ for the bioassay of EpDRF.

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Year:  1988        PMID： 3260190     DOI： 10.1016/0014-2999(88)90119-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  12 in total

1.  Role of epithelium in agonist-induced contractile responses of guinea-pig trachealis: influence of the surface through which drug enters the tissue.

Authors:  C F Iriarte; R Pascual; M M Villanueva; M Román; J Cortijo; E J Morcillo
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

2.  Innervation of the anococcygeus muscle of the rat.

Authors:  W G Dail; Y Carrillo; G Walton
Journal:  Cell Tissue Res       Date:  1990-01       Impact factor: 5.249

3.  Co-axial bioassay of a smooth muscle relaxant factor released from guinea-pig tracheal epithelium.

Authors:  L B Fernandes; J W Paterson; R G Goldie
Journal:  Br J Pharmacol       Date:  1989-01       Impact factor: 8.739

4.  Pharmacological evaluation of a guinea-pig tracheal epithelium-derived inhibitory factor (EpDIF).

Authors:  L B Fernandes; R G Goldie
Journal:  Br J Pharmacol       Date:  1990-07       Impact factor: 8.739

5.  The effect of inflammation on rat urinary bladder-dependent relaxation in coaxial bioassay system.

Authors:  K Inci; U B Ismailoglu; A Sahin; A Sungur; I Sahin-Erdemli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-03-25       Impact factor: 3.000

6.  The action of (+/-)L-660,863 [(+/-)3-(3-amino-1,2,4-oxadiazole-5-yl)-quinuclidine] at muscarinic receptor subtypes in vitro.

Authors:  R M Eglen; G C Harris; A P Ford; E H Wong; J R Pfister; R L Whiting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-04       Impact factor: 3.000

7.  Characterization of muscarinic receptors that mediate contraction of guinea-pig isolated trachea to choline esters: effect of removing epithelium.

Authors:  K J Morrison; P M Vanhoutte
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

8.  Airway epithelial cells regulate membrane potential, neurotransmission and muscle tone of the dog airway smooth muscle.

Authors:  Z Xie; H Hakoda; Y Ito
Journal:  J Physiol       Date:  1992-04       Impact factor: 5.182

9.  Characterization of muscarinic receptors mediating release of epithelial derived relaxant factor (EpDRF) in guinea-pig isolated trachea.

Authors:  R M Eglen; G C Harris; M Taylor; J R Pfister; R L Whiting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-07       Impact factor: 3.000

10.  The release of a non-prostanoid inhibitory factor from rabbit bronchus detected by co-axial bioassay.

Authors:  D Spina; C P Page
Journal:  Br J Pharmacol       Date:  1991-04       Impact factor: 8.739
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