BACKGROUND AND SUMMARY: Extracorporeal photopheresis (ECP) is a leukapheresis-based procedure used in the therapy of acute and chronic graft-versus-host disease (aGvHD, cGvHD) and other diseases. Based on the substantial efficacy and the excellent safety profile in the absence of immunosuppression ECP has established itself as a major treatment form for steroid-refractory GvHD. Here we review the current literature on ECP as a treatment option for patients with aGvHD as well as cGvHD. KEY MESSAGES: ECP is a well-established second-line therapy for cGvHD. Its role in the treatment of aGvHD is less clear but also points towards an effective second-line therapy option. In the future ECP could play a role in the prevention of GvHD. More experimental and randomized controlled trials are needed to define the best patient selection criteria, settings, and therapy regimens for GvHD.
BACKGROUND AND SUMMARY: Extracorporeal photopheresis (ECP) is a leukapheresis-based procedure used in the therapy of acute and chronic graft-versus-host disease (aGvHD, cGvHD) and other diseases. Based on the substantial efficacy and the excellent safety profile in the absence of immunosuppression ECP has established itself as a major treatment form for steroid-refractory GvHD. Here we review the current literature on ECP as a treatment option for patients with aGvHD as well as cGvHD. KEY MESSAGES: ECP is a well-established second-line therapy for cGvHD. Its role in the treatment of aGvHD is less clear but also points towards an effective second-line therapy option. In the future ECP could play a role in the prevention of GvHD. More experimental and randomized controlled trials are needed to define the best patient selection criteria, settings, and therapy regimens for GvHD.
Authors: L Salvaneschi; C Perotti; M Zecca; S Bernuzzi; G Viarengo; G Giorgiani; C Del Fante; P Bergamaschi; R Maccario; A Pession; F Locatelli Journal: Transfusion Date: 2001-10 Impact factor: 3.157
Authors: H T Greinix; B Volc-Platzer; W Rabitsch; B Gmeinhart; C Guevara-Pineda; P Kalhs; J Krutmann; H Hönigsmann; M Ciovica; R M Knobler Journal: Blood Date: 1998-11-01 Impact factor: 22.113
Authors: Erin Gatza; Clare E Rogers; Shawn G Clouthier; Kathleen P Lowler; Isao Tawara; Chen Liu; Pavan Reddy; James L M Ferrara Journal: Blood Date: 2008-04-14 Impact factor: 22.113
Authors: Mohsin Ilyas Malik; Mark Litzow; William Hogan; Mrinal Patnaik; Mohammad Hassan Murad; Larry J Prokop; Jeffrey L Winters; Shahrukh Hashmi Journal: Blood Res Date: 2014-06-25
Authors: Blanca Boluda; Antonio Solana-Altabella; Isabel Cano; Evelyn Acuña-Cruz; Rebeca Rodríguez-Veiga; Octavio Ballesta-López; Juan Eduardo Megías-Vericat; David Martínez-Cuadrón; Ines Gómez; Pilar Solves; Ignacio Lorenzo; Jose Luis Piñana; Jaime Sanz; Manuel Guerreiro; Juan Montoro Gómez; Alvaro Díaz-González; Javier Marco; Albert Blanco; Miguel Á Sanz; Pau Montesinos Journal: J Clin Apher Date: 2021-05-08 Impact factor: 2.821
Authors: Giancarlo Fatobene; Ana Cordeiro; Livia Mariano; Marcia Silva; Luis Bouzas; Nelson Hamerschlak; Maria Cristina Macedo; Alessandra Petta; Vaneuza Funke; Yana Novis; Mary E Flowers; Vanderson Rocha Journal: Hematol Transfus Cell Ther Date: 2022-01-25