Jennifer H Lingler1,2, Susan M Sereika1, Meryl A Butters3, Ann D Cohen2,3, William E Klunk2,3,4, Melissa L Knox1, Eric McDade5, Neelesh K Nadkarni2,4,6, J Scott Roberts7, Lisa K Tamres1, Oscar L Lopez2,3,4. 1. Department of Health and Community Systems, School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 2. Alzheimer's Disease Research Center, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 3. Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 4. Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 5. Department of Neurology, School of Medicine, Washington University, St. Louis, Missouri, USA. 6. Department of Medicine (Geriatric Medicine), School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 7. University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Abstract
INTRODUCTION: Recent studies suggest that Alzheimer's disease (AD) biomarker disclosure has no discernable psychological impact on cognitively healthy persons. Far less is known about how such results affect symptomatic individuals and their caregivers. METHODS: Randomized controlled trial of 82 mild cognitive impairment (MCI) patient and caregiver dyads (total n = 164) to determine the effect of receiving amyloid positron emission tomography results on understanding of, and perceived efficacy to cope with, MCI over 52 weeks of follow-up. RESULTS: Gains in the primary outcomes were not consistently observed. Amyloid negative patients reported greater perceived ambiguity regarding MCI at follow-up, while moderate and sustained emotional distress was observed in patients, and to a lesser extent, caregivers, of those who were amyloid positive. There was no corresponding increase in depressive symptoms. DISCUSSION: These findings point to the possibility that both MCI patients and caregivers may need emotional support after the disclosure of amyloid scan results.
RCT Entities:
INTRODUCTION: Recent studies suggest that Alzheimer's disease (AD) biomarker disclosure has no discernable psychological impact on cognitively healthy persons. Far less is known about how such results affect symptomatic individuals and their caregivers. METHODS: Randomized controlled trial of 82 mild cognitive impairment (MCI) patient and caregiver dyads (total n = 164) to determine the effect of receiving amyloid positron emission tomography results on understanding of, and perceived efficacy to cope with, MCI over 52 weeks of follow-up. RESULTS: Gains in the primary outcomes were not consistently observed. Amyloid negative patients reported greater perceived ambiguity regarding MCI at follow-up, while moderate and sustained emotional distress was observed in patients, and to a lesser extent, caregivers, of those who were amyloid positive. There was no corresponding increase in depressive symptoms. DISCUSSION: These findings point to the possibility that both MCI patients and caregivers may need emotional support after the disclosure of amyloid scan results.
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