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Literature DB >> 32583604

Microbial Products and Metabolites Contributing to Alcohol-Related Liver Disease.

Bei Gao¹, Atoosa Emami¹, Shilpa Nath¹, Bernd Schnabl^1,2.

Abstract

As a serious public health concern, alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota. The liver and gut communicate via the gut-liver axis, through which microbial products and metabolites translocate to the liver. Here, the current knowledge of various microbial products and metabolites which contribute to the alcohol-related liver diseases, including bile acids, indole-3-acetic acid, butyrate, long-chain fatty acids, endotoxin, cytolysin, β-glucan, and candidalysin is reviewed. Some of these might serve as therapeutic targets for alcohol-related liver disease.

Entities: Chemical

Keywords: alcoholic liver disease; microbiome; mycobiome

Mesh：

Substances：

Year: 2020 PMID： 32583604 PMCID： PMC7758187 DOI： 10.1002/mnfr.202000023

Source DB: PubMed Journal: Mol Nutr Food Res ISSN： 1613-4125 Impact factor: 5.914

73 in total

Review 1. Sex difference in alcohol-related organ injury.

Authors: N Sato; K O Lindros; E Baraona; K Ikejima; E Mezey; H A Järveläinen; V A Ramchandani
Journal: Alcohol Clin Exp Res Date: 2001-05 Impact factor: 3.455

2. Variant in PNPLA3 is associated with alcoholic liver disease.

Authors: Chao Tian; Renee P Stokowski; David Kershenobich; Dennis G Ballinger; David A Hinds
Journal: Nat Genet Date: 2009-11-29 Impact factor: 38.330

3. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease.

Authors: A Parlesak; C Schäfer; T Schütz; J C Bode; C Bode
Journal: J Hepatol Date: 2000-05 Impact factor: 25.083

4. Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and thromboxane B2.

Authors: A A Nanji; U Khettry; S M Sadrzadeh; T Yamanaka
Journal: Am J Pathol Date: 1993-02 Impact factor: 4.307

5. Tributyrin supplementation protects mice from acute ethanol-induced gut injury.

Authors: Gail A Cresci; Katelyn Bush; Laura E Nagy
Journal: Alcohol Clin Exp Res Date: 2014-05-30 Impact factor: 3.455

6. Cytolysin-positive Enterococcus faecalis is not increased in patients with non-alcoholic steatohepatitis.

Authors: Sonja Lang; Münevver Demir; Yi Duan; Anna Martin; Bernd Schnabl
Journal: Liver Int Date: 2020-01-23 Impact factor: 5.828

Review 7. The gut-liver axis and the intersection with the microbiome.

Authors: Anupriya Tripathi; Justine Debelius; David A Brenner; Michael Karin; Rohit Loomba; Bernd Schnabl; Rob Knight
Journal: Nat Rev Gastroenterol Hepatol Date: 2018-07 Impact factor: 46.802

8. Intestinal fungi contribute to development of alcoholic liver disease.

Authors: An-Ming Yang; Tatsuo Inamine; Katrin Hochrath; Peng Chen; Lirui Wang; Cristina Llorente; Sena Bluemel; Phillipp Hartmann; Jun Xu; Yukinori Koyama; Tatiana Kisseleva; Manolito G Torralba; Kelvin Moncera; Karen Beeri; Chien-Sheng Chen; Kim Freese; Claus Hellerbrand; Serene Ml Lee; Hal M Hoffman; Wajahat Z Mehal; Guadalupe Garcia-Tsao; Ece A Mutlu; Ali Keshavarzian; Gordon D Brown; Samuel B Ho; Ramon Bataller; Peter Stärkel; Derrick E Fouts; Bernd Schnabl
Journal: J Clin Invest Date: 2017-05-22 Impact factor: 19.456

Review 4. Translational Approaches with Antioxidant Phytochemicals against Alcohol-Mediated Oxidative Stress, Gut Dysbiosis, Intestinal Barrier Dysfunction, and Fatty Liver Disease.

Authors: Jacob W Ballway; Byoung-Joon Song
Journal: Antioxidants (Basel) Date: 2021-03-04

4 in total

Microbial Products and Metabolites Contributing to Alcohol-Related Liver Disease.

Review 1. Sex difference in alcohol-related organ injury.

2. Variant in PNPLA3 is associated with alcoholic liver disease.

3. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease.

4. Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and thromboxane B2.

5. Tributyrin supplementation protects mice from acute ethanol-induced gut injury.

6. Cytolysin-positive Enterococcus faecalis is not increased in patients with non-alcoholic steatohepatitis.

Review 7. The gut-liver axis and the intersection with the microbiome.

8. Intestinal fungi contribute to development of alcoholic liver disease.

Review 9. Leaky Gut As a Danger Signal for Autoimmune Diseases.

Review 10. Endotoxin and Kupffer cell activation in alcoholic liver disease.

Review 1. Dual Role of Indoles Derived From Intestinal Microbiota on Human Health.

Review 2. The Role of Gut Bacteria and Fungi in Alcohol-Associated Liver Disease.

3. Dietary Goji Shapes the Gut Microbiota to Prevent the Liver Injury Induced by Acute Alcohol Intake.

Review 4. Translational Approaches with Antioxidant Phytochemicals against Alcohol-Mediated Oxidative Stress, Gut Dysbiosis, Intestinal Barrier Dysfunction, and Fatty Liver Disease.