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Literature DB >> 19946271

Variant in PNPLA3 is associated with alcoholic liver disease.

Chao Tian¹, Renee P Stokowski, David Kershenobich, Dennis G Ballinger, David A Hinds.

Abstract

Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)).

Entities: Chemical Disease Gene Mutation

Mesh：

Substances：

Year: 2009 PMID： 19946271 DOI： 10.1038/ng.488

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

12 in total

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3. A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping.

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5. Risk factors for chronic liver disease in Blacks, Mexican Americans, and Whites in the United States: results from NHANES IV, 1999-2004.

Authors: Yvonne N Flores; Hal F Yee; Mei Leng; José J Escarce; Roshan Bastani; Jorge Salmerón; Leo S Morales
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6. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.

Authors: A Kotronen; L E Johansson; L M Johansson; C Roos; J Westerbacka; A Hamsten; R Bergholm; P Arkkila; J Arola; T Kiviluoto; R M Fisher; E Ehrenborg; M Orho-Melander; M Ridderstråle; L Groop; H Yki-Järvinen
Journal: Diabetologia Date: 2009-02-18 Impact factor: 10.122

7. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.

Authors: Christopher M Jenkins; David J Mancuso; Wei Yan; Harold F Sims; Beverly Gibson; Richard W Gross
Journal: J Biol Chem Date: 2004-09-10 Impact factor: 5.157

Review 8. The epidemiology of alcoholic liver disease.

Authors: Robert E Mann; Reginald G Smart; Richard Govoni
Journal: Alcohol Res Health Date: 2003

9. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.

Authors: Xin Yuan; Dawn Waterworth; John R B Perry; Noha Lim; Kijoung Song; John C Chambers; Weihua Zhang; Peter Vollenweider; Heide Stirnadel; Toby Johnson; Sven Bergmann; Noam D Beckmann; Yun Li; Luigi Ferrucci; David Melzer; Dena Hernandez; Andrew Singleton; James Scott; Paul Elliott; Gerard Waeber; Lon Cardon; Timothy M Frayling; Jaspal S Kooner; Vincent Mooser
Journal: Am J Hum Genet Date: 2008-10 Impact factor: 11.025

10. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.

Authors: Stefano Romeo; Julia Kozlitina; Chao Xing; Alexander Pertsemlidis; David Cox; Len A Pennacchio; Eric Boerwinkle; Jonathan C Cohen; Helen H Hobbs
Journal: Nat Genet Date: 2008-09-25 Impact factor: 38.330

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Journal: Hepatology Date: 2012-06-06 Impact factor: 17.425

2. Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease.

Authors: Weiqin Chen; Benny Chang; Lan Li; Lawrence Chan
Journal: Hepatology Date: 2010-09 Impact factor: 17.425

Review 3. Epidemiology of NAFLD and Type 2 Diabetes: Health Disparities Among Persons of Hispanic Origin.

Authors: Mariana Lazo; Usama Bilal; Rafael Perez-Escamilla
Journal: Curr Diab Rep Date: 2015-12 Impact factor: 4.810

4. New Approaches for Studying Alcoholic Liver Disease.

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Journal: Curr Pathobiol Rep Date: 2014-09-14

Review 5. Alcoholic liver disease: the gut microbiome and liver cross talk.

Authors: Phillipp Hartmann; Caroline T Seebauer; Bernd Schnabl
Journal: Alcohol Clin Exp Res Date: 2015-05 Impact factor: 3.455

Review 6. Structure, Function and Metabolism of Hepatic and Adipose Tissue Lipid Droplets: Implications in Alcoholic Liver Disease.

Authors: Sathish Kumar Natarajan; Karuna Rasineni; Murali Ganesan; Dan Feng; Benita L McVicker; Mark A McNiven; Natalia A Osna; Justin L Mott; Carol A Casey; Kusum K Kharbanda
Journal: Curr Mol Pharmacol Date: 2017 Impact factor: 3.339