Duo Zhang1, Jingzhang Sun1, P Hendrik Pretorius2, Michael King2, Greta S P Mok1,3. 1. Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau SAR, China. 2. Department of Radiology, University of Massachusetts Medical School, Worcester, USA. 3. Center for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Macau SAR, China.
Abstract
PURPOSE: Respiratory gating reduces respiratory blur in cardiac single photon emission computed tomography (SPECT). It can be implemented as three gating schemes: (a) equal amplitude-based gating (AG); (b) phase or time-based gating (TG); or (c) equal count-based gating (CG), that is, a variant of amplitude-based method. The goal of this study is to evaluate the effectiveness of these respiratory gating methods for patients with different respiratory patterns in myocardial perfusion SPECT. METHODS: We reviewed 1274 anonymized patient respiratory traces obtained via the Vicon motion-tracking system during their 99m Tc-sestamibi SPECT scans and grouped them into four breathing categories: (a) regular respiration (RR); (b) periodic respiration (PR); (c) respiration with apnea (AR); and (d) unclassified respiration (UR). For each respiratory pattern, 15 patients were randomly selected and their list-mode data were rebinned using the three gating schemes. A preliminary reconstruction was performed for each gate with the heart region segmented and registered to a reference gate to estimate the respiratory motion. A final reconstruction incorporating respiratory motion correction was done to get a final image set. The estimated respiratory motion, the full-width-at-half-maxima (FWHM) measured across the image intensity profile of the left ventricle wall, as well as the normalized standard deviation measured in a uniform cuboid region of the thorax were analyzed. RESULTS: There are 47.1%, 24.3%, 13.5%, and 15.1% RR, PR, AR, and UR patients, respectively, among the 1274 patients in this study. The differences among the three gating schemes in RR were smaller than other respiratory patterns. The AG and CG methods showed statistically larger motion estimation than TG particularly in the AR and PR patterns. Noise of AG varied more in different gates, especially for AR and UR patterns. CONCLUSION: More than half of the patients reviewed exhibited nonregular breathing patterns. Amplitude-based gating, that is, AG and CG, is a preferred gating method for such patterns and is a robust respiratory gating implementation method given the respiratory pattern of the patients is unknown before data acquisition. Phase gating is also a feasible option for regular respiratory pattern.
PURPOSE: Respiratory gating reduces respiratory blur in cardiac single photon emission computed tomography (SPECT). It can be implemented as three gating schemes: (a) equal amplitude-based gating (AG); (b) phase or time-based gating (TG); or (c) equal count-based gating (CG), that is, a variant of amplitude-based method. The goal of this study is to evaluate the effectiveness of these respiratory gating methods for patients with different respiratory patterns in myocardial perfusion SPECT. METHODS: We reviewed 1274 anonymized patient respiratory traces obtained via the Vicon motion-tracking system during their 99m Tc-sestamibi SPECT scans and grouped them into four breathing categories: (a) regular respiration (RR); (b) periodic respiration (PR); (c) respiration with apnea (AR); and (d) unclassified respiration (UR). For each respiratory pattern, 15 patients were randomly selected and their list-mode data were rebinned using the three gating schemes. A preliminary reconstruction was performed for each gate with the heart region segmented and registered to a reference gate to estimate the respiratory motion. A final reconstruction incorporating respiratory motion correction was done to get a final image set. The estimated respiratory motion, the full-width-at-half-maxima (FWHM) measured across the image intensity profile of the left ventricle wall, as well as the normalized standard deviation measured in a uniform cuboid region of the thorax were analyzed. RESULTS: There are 47.1%, 24.3%, 13.5%, and 15.1% RR, PR, AR, and URpatients, respectively, among the 1274 patients in this study. The differences among the three gating schemes in RR were smaller than other respiratory patterns. The AG and CG methods showed statistically larger motion estimation than TG particularly in the AR and PR patterns. Noise of AG varied more in different gates, especially for AR and UR patterns. CONCLUSION: More than half of the patients reviewed exhibited nonregular breathing patterns. Amplitude-based gating, that is, AG and CG, is a preferred gating method for such patterns and is a robust respiratory gating implementation method given the respiratory pattern of the patients is unknown before data acquisition. Phase gating is also a feasible option for regular respiratory pattern.
Authors: Shouyi Wang; Stephen R Bowen; W Art Chaovalitwongse; George A Sandison; Thomas J Grabowski; Paul E Kinahan Journal: Phys Med Biol Date: 2014-02-07 Impact factor: 3.609
Authors: A Mortara; P Sleight; G D Pinna; R Maestri; A Prpa; M T La Rovere; F Cobelli; L Tavazzi Journal: Circulation Date: 1997-07-01 Impact factor: 29.690
Authors: Sang-June Park; Dan Ionascu; Joseph Killoran; Marcelo Mamede; Victor H Gerbaudo; Lee Chin; Ross Berbeco Journal: Phys Med Biol Date: 2008-06-19 Impact factor: 3.609
Authors: Jeffrey R Olsen; Wei Lu; James P Hubenschmidt; Michelle M Nystrom; Paul Klahr; Jeffrey D Bradley; Daniel A Low; Parag J Parikh Journal: Int J Radiat Oncol Biol Phys Date: 2007-11-26 Impact factor: 7.038
Authors: A F Abdelnour; S A Nehmeh; T Pan; J L Humm; P Vernon; H Schöder; K E Rosenzweig; G S Mageras; E Yorke; S M Larson; Y E Erdi Journal: Phys Med Biol Date: 2007-05-18 Impact factor: 3.609