Literature DB >> 3258192

Molecular analysis of a t(7;14)(q35;q32) chromosome translocation in a T cell leukemia of a patient with ataxia telangiectasia.

G Russo1, M Isobe, L Pegoraro, J Finan, P C Nowell, C M Croce.   

Abstract

Molecular analysis of somatic cell hybrids derived from T cells carrying a t(7;14)(q35;q32) chromosomal translocation from a patient with ataxia telangiectasia and T cell leukemia indicates that the breakpoint on chromosome 14 is proximal to the IgH locus and to the D14S1 locus, while the breakpoint on chromosome 7 involves the T cell receptor beta chain locus immediately 5' to J beta 1.5 on chromosome 7. The separation of V beta and C beta observed in somatic cell hybrids defined the orientation of the T cell receptor beta chain locus on chromosome 7 where the V beta genes are centromeric and the C beta genes are telomeric. A novel chromosomal alteration, undetected cytogenetically, was revealed as being an inversion with duplication of the distal band of chromosome 14q32. The importance of the 14q32 region in the leukemogenic process is discussed.

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Year:  1988        PMID： 3258192     DOI： 10.1016/0092-8674(88)90495-3

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  25 in total

1.  TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.

Authors:  M Teitell; M A Damore; G G Sulur; D E Turner; M H Stern; J W Said; C T Denny; R Wall
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

2.  Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.

Authors:  K Huebner; T Druck; C M Croce; H J Thiesen
Journal:  Am J Hum Genet       Date:  1991-04       Impact factor: 11.025

3.  Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers.

Authors:  E Donti; L Lanfrancone; K Huebner; A Pascucci; G Venti; G Pengue; F Grignani; C M Croce; L Lania; P G Pelicci
Journal:  Hum Genet       Date:  1990-04       Impact factor: 4.132

4.  A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden.

Authors:  Andrew Campbell; Brittany Krupp; Jared Bushman; Mark Noble; Christoph Pröschel; Margot Mayer-Pröschel
Journal:  Hum Mol Genet       Date:  2015-08-26       Impact factor: 6.150

Review 5.  Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications.

Authors:  George A Calin; Carlo M Croce
Journal:  J Clin Invest       Date:  2007-08       Impact factor: 14.808

6.  Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes.

Authors:  W K Kaufmann; J C Boyer; L L Estabrooks; S J Wilson
Journal:  Mol Cell Biol       Date:  1991-07       Impact factor: 4.272

7.  Localization of the human angiogenin gene to chromosome band 14q11, proximal to the T cell receptor alpha/delta locus.

Authors:  S Weremowicz; E A Fox; C C Morton; B L Vallee
Journal:  Am J Hum Genet       Date:  1990-12       Impact factor: 11.025

8.  Haplotyping the human T-cell receptor beta-chain gene complex by use of restriction fragment length polymorphisms.

Authors:  P Charmley; A Chao; P Concannon; L Hood; R A Gatti
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

9.  Tissue specificity of chromosomal rearrangements in ataxia-telangiectasia.

Authors:  T L Kojis; R R Schreck; R A Gatti; R S Sparkes
Journal:  Hum Genet       Date:  1989-11       Impact factor: 4.132

Review 10.  T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15;q32) [TCRγ-TCL1A translocation]: a case report and a review of the literature.

Authors:  Kei-Ji Sugimoto; Asami Shimada; Mutsumi Wakabayashi; Yasunobu Sekiguchi; Hiroshi Izumi; Yasunori Ota; Norio Komatsu; Masaaki Noguchi
Journal:  Int J Clin Exp Pathol       Date:  2014-04-15
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