Paulius Vaiciulis1, Rasa Liutkeviciene2, Vykintas Liutkevicius3, Alvita Vilkeviciute2, Greta Gedvilaite2, Virgilijus Uloza3. 1. Department of Otorhinolaryngology, Lithuanian University of Health Sciences, Kaunas, Lithuania paulius.vaiciulis@lsmuni.lt. 2. Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania. 3. Department of Otorhinolaryngology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Abstract
BACKGROUND/AIM: The study aimed to evaluate associations of relative leukocyte telomere length (LTL) and polymorphisms of telomere length-associated genes TERT (rs2736098), TERT-CLPTM1L (rs401681), TRF1 (rs1545827, rs10107605) and TNKS2 (rs10509637, rs10509639) in patients with laryngeal squamous cell carcinoma (LSCC). MATERIALS AND METHODS: The study consisted of 300 patients with LSCC and 369 healthy control subjects. Genotyping and relative LTL measuring were carried out using qPCR. RESULTS: Relative LTL was statistically significantly shorter in the G3 (tumor differentiation grade) subgroup of patients with LSCC compared to the G1 and G2 subgroups. Significant differences were found in genotype distributions of TERT rs401681 and TNKS2 rs10509639 between the study groups. TERT rs401681 C/T and T/T genotypes were associated with approximately 30% decreased odds of LSCC development. CONCLUSION: LTL was shorter in the G3 subgroup compared to the G2 and G1 subgroups of LSCC patients. TERT rs401681 and its C/T and T/T genotypes were associated with decreased odds of overall LSCC development. Copyright
BACKGROUND/AIM: The study aimed to evaluate associations of relative leukocyte telomere length (LTL) and polymorphisms of telomere length-associated genes TERT (rs2736098), TERT-CLPTM1L (rs401681), TRF1 (rs1545827, rs10107605) and TNKS2 (rs10509637, rs10509639) in patients with laryngeal squamous cell carcinoma (LSCC). MATERIALS AND METHODS: The study consisted of 300 patients with LSCC and 369 healthy control subjects. Genotyping and relative LTL measuring were carried out using qPCR. RESULTS: Relative LTL was statistically significantly shorter in the G3 (tumor differentiation grade) subgroup of patients with LSCC compared to the G1 and G2 subgroups. Significant differences were found in genotype distributions of TERTrs401681 and TNKS2rs10509639 between the study groups. TERTrs401681 C/T and T/T genotypes were associated with approximately 30% decreased odds of LSCC development. CONCLUSION: LTL was shorter in the G3 subgroup compared to the G2 and G1 subgroups of LSCC patients. TERTrs401681 and its C/T and T/T genotypes were associated with decreased odds of overall LSCC development. Copyright
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