| Literature DB >> 32573498 |
Hillary Hosier1, Shelli F Farhadian2, Raffaella A Morotti3, Uma Deshmukh1, Alice Lu-Culligan4, Katherine H Campbell1, Yuki Yasumoto5, Chantal Bf Vogels6, Arnau Casanovas-Massana6, Pavithra Vijayakumar1, Bertie Geng1, Camila D Odio2, John Fournier2, Anderson F Brito6, Joseph R Fauver6, Feimei Liu4, Tara Alpert7, Reshef Tal1, Klara Szigeti-Buck3, Sudhir Perincheri3, Christopher Larsen8, Aileen M Gariepy1, Gabriela Aguilar1, Kristen L Fardelmann9, Malini Harigopal3, Hugh S Taylor1, Christian M Pettker1, Anne L Wyllie6, Charles Dela Cruz10, Aaron M Ring4, Nathan D Grubaugh6, Albert I Ko6, Tamas L Horvath5, Akiko Iwasaki4, Uma M Reddy1, Heather S Lipkind1.
Abstract
BACKGROUNDThe effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption.METHODSWe analyzed the placenta for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through molecular and immunohistochemical assays and by and electron microscopy and measured the maternal antibody response in the blood to this infection.RESULTSSARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the materno-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for the vasculopathy typically associated with preeclampsia.CONCLUSIONThis case demonstrates SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with COVID-19.FUNDINGBeatrice Kleinberg Neuwirth Fund and Fast Grant Emergent Ventures funding from the Mercatus Center at George Mason University. The funding bodies did not have roles in the design of the study or data collection, analysis, and interpretation and played no role in writing the manuscript.Entities:
Keywords: COVID-19; Molecular pathology; Reproductive Biology
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Year: 2020 PMID： 32573498 PMCID： PMC7456249 DOI： 10.1172/JCI139569
Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808