Literature DB >> 32571810

Role of Whole-Genome Sequencing in Characterizing the Mechanism of Action of para-Aminosalicylic Acid and Its Resistance.

Giovanni Satta1,2, Adam A Witney3, Neelu Begum4, Julio Ortiz Canseco4, Andrew N Boa5, Timothy D McHugh4.   

Abstract

para-Aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is still not completely understood. The main aim of this project was to identify new potential mechanisms of action and resistance to PAS by performing whole-genome sequencing on PAS-resistant laboratory mutants. A new variant in the folC gene was identified, as well as some other mutations that require further study.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  para-aminosalicylic acid; tuberculosis; whole-genome sequencing

Mesh：

Substances：

Year:  2020        PMID： 32571810      PMCID： PMC7449179          DOI： 10.1128/AAC.00675-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.

Authors:  Koen Andries; Peter Verhasselt; Jerome Guillemont; Hinrich W H Göhlmann; Jean-Marc Neefs; Hans Winkler; Jef Van Gestel; Philip Timmerman; Min Zhu; Ennis Lee; Peter Williams; Didier de Chaffoy; Emma Huitric; Sven Hoffner; Emmanuelle Cambau; Chantal Truffot-Pernot; Nacer Lounis; Vincent Jarlier
Journal:  Science       Date:  2004-12-09       Impact factor: 47.728

Review 2.  Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance.

Authors:  Yusuke Minato; Joshua M Thiede; Shannon Lynn Kordus; Edward J McKlveen; Breanna J Turman; Anthony D Baughn
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

3.  Mechanisms of streptomycin resistance: selection of mutations in the 16S rRNA gene conferring resistance.

Authors:  B Springer; Y G Kidan; T Prammananan; K Ellrott; E C Böttger; P Sander
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

4.  N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in patients with drug-resistant pulmonary tuberculosis.

Authors:  Sherwin K B Sy; Lizanne de Kock; Andreas H Diacon; Cedric J Werely; Huiming Xia; Bernd Rosenkranz; Lize van der Merwe; Peter R Donald
Journal:  Antimicrob Agents Chemother       Date:  2015-05-11       Impact factor: 5.191

5.  Genetic determinants involved in p-aminosalicylic acid resistance in clinical isolates from tuberculosis patients in northern China from 2006 to 2012.

Authors:  Xiaobing Zhang; Liguo Liu; Yan Zhang; Guangming Dai; Hairong Huang; Qi Jin
Journal:  Antimicrob Agents Chemother       Date:  2014-11-24       Impact factor: 5.191

6.  Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG.

Authors:  Santiago Ramón-García; Virginie Mick; Elisa Dainese; Carlos Martín; Charles J Thompson; Edda De Rossi; Riccardo Manganelli; José A Aínsa
Journal:  Antimicrob Agents Chemother       Date:  2012-01-09       Impact factor: 5.191

7.  Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis.

Authors:  Vanessa Mathys; René Wintjens; Philippe Lefevre; Julie Bertout; Amit Singhal; Mehdi Kiass; Natalia Kurepina; Xiao-Ming Wang; Barun Mathema; Alain Baulard; Barry N Kreiswirth; Pablo Bifani
Journal:  Antimicrob Agents Chemother       Date:  2009-02-23       Impact factor: 5.191

8.  Folate Biosynthesis, Reduction, and Polyglutamylation and the Interconversion of Folate Derivatives.

Authors:  Jacalyn M Green; Rowena G Matthews
Journal:  EcoSal Plus       Date:  2007-04

9.  Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.

Authors:  Amanda S Fivian-Hughes; Joanna Houghton; Elaine O Davis
Journal:  Microbiology       Date:  2011-10-27       Impact factor: 2.777

10.  Multi-omics comparisons of p-aminosalicylic acid (PAS) resistance in folC mutated and un-mutated Mycobacterium tuberculosis strains.

Authors:  Wenjing Wei; Huimin Yan; Jiao Zhao; Haicheng Li; Zhenyan Li; Huixin Guo; Xuezhi Wang; Ying Zhou; Xiaoli Zhang; Jincheng Zeng; Tao Chen; Lin Zhou
Journal:  Emerg Microbes Infect       Date:  2019       Impact factor: 7.163
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  1 in total

Review 1.  Drug Discovery for Mycobacterium tuberculosis Using Structure-Based Computer-Aided Drug Design Approach.

Authors:  Murtala A Ejalonibu; Segun A Ogundare; Ahmed A Elrashedy; Morufat A Ejalonibu; Monsurat M Lawal; Ndumiso N Mhlongo; Hezekiel M Kumalo
Journal:  Int J Mol Sci       Date:  2021-12-09       Impact factor: 5.923
  1 in total

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