Literature DB >> 25421465

Genetic determinants involved in p-aminosalicylic acid resistance in clinical isolates from tuberculosis patients in northern China from 2006 to 2012.

Xiaobing Zhang1, Liguo Liu1, Yan Zhang1, Guangming Dai2, Hairong Huang3, Qi Jin4.   

Abstract

p-Aminosalicylic acid (PAS) is an important compound for treating multidrug-resistant tuberculosis (TB). Previous studies showed that thyA mutations are often related to PAS resistance in clinical isolates. We performed a systematic analysis of isolate genotypes and detected mutations in three folate pathway genes (folC, thyA, and ribD) in 61.1% (127/208) of PAS-resistant isolates, including 11 double mutants. This result expands our knowledge about the distribution and frequency of mutations related to PAS resistance in mycobacterial clinical isolates.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25421465      PMCID： PMC4335845          DOI： 10.1128/AAC.03695-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  31 in total

1.  Para-aminosalicylic acid in the treatment of tuberculosis.

Authors:  J LEHMANN
Journal:  Lancet       Date:  1946-01-05       Impact factor: 79.321

Review 2.  Importance of the genetic diversity within the Mycobacterium tuberculosis complex for the development of novel antibiotics and diagnostic tests of drug resistance.

Authors:  Claudio U Köser; Silke Feuerriegel; David K Summers; John A C Archer; Stefan Niemann
Journal:  Antimicrob Agents Chemother       Date:  2012-09-24       Impact factor: 5.191

3.  WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update.

Authors:  D Falzon; E Jaramillo; H J Schünemann; M Arentz; M Bauer; J Bayona; L Blanc; J A Caminero; C L Daley; C Duncombe; C Fitzpatrick; A Gebhard; H Getahun; M Henkens; T H Holtz; J Keravec; S Keshavjee; A J Khan; R Kulier; V Leimane; C Lienhardt; C Lu; A Mariandyshev; G B Migliori; F Mirzayev; C D Mitnick; P Nunn; G Nwagboniwe; O Oxlade; D Palmero; P Pavlinac; M I Quelapio; M C Raviglione; M L Rich; S Royce; S Rüsch-Gerdes; A Salakaia; R Sarin; D Sculier; F Varaine; M Vitoria; J L Walson; F Wares; K Weyer; R A White; M Zignol
Journal:  Eur Respir J       Date:  2011-08-04       Impact factor: 16.671

4.  Thr202Ala in thyA is a marker for the Latin American Mediterranean lineage of the Mycobacterium tuberculosis complex rather than para-aminosalicylic acid resistance.

Authors:  Silke Feuerriegel; Claudio Köser; Leona Trübe; John Archer; Sabine Rüsch Gerdes; Elvira Richter; Stefan Niemann
Journal:  Antimicrob Agents Chemother       Date:  2010-08-30       Impact factor: 5.191

5.  Subpopulation analysis of heteroresistance to fluoroquinolone in Mycobacterium tuberculosis isolates from Beijing, China.

Authors:  Xiaobing Zhang; Bing Zhao; Liguo Liu; Yafang Zhu; Yanlin Zhao; Qi Jin
Journal:  J Clin Microbiol       Date:  2012-01-18       Impact factor: 5.948

6.  Validation of pncA gene sequencing in combination with the mycobacterial growth indicator tube method to test susceptibility of Mycobacterium tuberculosis to pyrazinamide.

Authors:  Sami O Simons; Jakko van Ingen; Tridia van der Laan; Arnout Mulder; P N Richard Dekhuijzen; Martin J Boeree; Dick van Soolingen
Journal:  J Clin Microbiol       Date:  2011-11-16       Impact factor: 5.948

7.  Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis.

Authors:  Vanessa Mathys; René Wintjens; Philippe Lefevre; Julie Bertout; Amit Singhal; Mehdi Kiass; Natalia Kurepina; Xiao-Ming Wang; Barun Mathema; Alain Baulard; Barry N Kreiswirth; Pablo Bifani
Journal:  Antimicrob Agents Chemother       Date:  2009-02-23       Impact factor: 5.191

8.  [Mutations in the thymidylate synthase gene is a major mechanism in the para-aminosalicylic acid resistance of M. tuberculosis].

Authors:  Zong-de Zhang; Yan-Lin Zhao; Zi-Hui Li; Hong-Yan Jia; Yu-Hong Liu; Xi Chen; Zhong-Quan Liu; Bo-Ping Du; Ai-Ying Xing; Yu Ma
Journal:  Zhonghua Jie He He Hu Xi Za Zhi       Date:  2007-09

9.  Challenging a dogma: antimicrobial susceptibility testing breakpoints for Mycobacterium tuberculosis.

Authors:  Kristian Ängeby; Pontus Juréen; Gunnar Kahlmeter; Sven E Hoffner; Thomas Schön
Journal:  Bull World Health Organ       Date:  2012-05-29       Impact factor: 9.408

10.  Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.

Authors:  Amanda S Fivian-Hughes; Joanna Houghton; Elaine O Davis
Journal:  Microbiology       Date:  2011-10-27       Impact factor: 2.777
View more
  21 in total

1.  Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.

Authors:  Behnoush Hajian; Eric Scocchera; Carolyn Shoen; Jolanta Krucinska; Kishore Viswanathan; Narendran G-Dayanandan; Heidi Erlandsen; Alexavier Estrada; Katarína Mikušová; Jana Korduláková; Michael Cynamon; Dennis Wright
Journal:  Cell Chem Biol       Date:  2019-03-28       Impact factor: 8.116

2.  Deletion of sigB Causes Increased Sensitivity to para-Aminosalicylic Acid and Sulfamethoxazole in Mycobacterium tuberculosis.

Authors:  Shan-Shan Yang; Yang-Bo Hu; Xu-De Wang; Yun-Rong Gao; Kun Li; Xian-En Zhang; Shi-Yun Chen; Tian-Yu Zhang; Jing Gu; Jiao-Yu Deng
Journal:  Antimicrob Agents Chemother       Date:  2017-09-22       Impact factor: 5.191

Review 3.  Antibiotic resistance mechanisms in M. tuberculosis: an update.

Authors:  Liem Nguyen
Journal:  Arch Toxicol       Date:  2016-05-09       Impact factor: 5.153

Review 4.  Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance.

Authors:  Yusuke Minato; Joshua M Thiede; Shannon Lynn Kordus; Edward J McKlveen; Breanna J Turman; Anthony D Baughn
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

Review 5.  Methodological and Clinical Aspects of the Molecular Epidemiology of Mycobacterium tuberculosis and Other Mycobacteria.

Authors:  Tomasz Jagielski; Alina Minias; Jakko van Ingen; Nalin Rastogi; Anna Brzostek; Anna Żaczek; Jarosław Dziadek
Journal:  Clin Microbiol Rev       Date:  2016-04       Impact factor: 26.132

6.  Role of Whole-Genome Sequencing in Characterizing the Mechanism of Action of para-Aminosalicylic Acid and Its Resistance.

Authors:  Giovanni Satta; Adam A Witney; Neelu Begum; Julio Ortiz Canseco; Andrew N Boa; Timothy D McHugh
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

Review 7.  Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance.

Authors:  Shannon Lynn Kordus; Anthony David Baughn
Journal:  Medchemcomm       Date:  2019-05-08       Impact factor: 3.597

8.  Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.

Authors:  Yu-Shan Cheng; James C Sacchettini
Journal:  Biochemistry       Date:  2016-02-05       Impact factor: 3.162

9.  Mutations Found in embCAB, embR, and ubiA Genes of Ethambutol-Sensitive and -Resistant Mycobacterium tuberculosis Clinical Isolates from China.

Authors:  Yuhui Xu; Hongyan Jia; Hairong Huang; Zhaogang Sun; Zongde Zhang
Journal:  Biomed Res Int       Date:  2015-08-31       Impact factor: 3.411

10.  dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains.

Authors:  Danesh Moradigaravand; Louis Grandjean; Elena Martinez; Hao Li; Jun Zheng; Jorge Coronel; David Moore; M Estée Török; Vitali Sintchenko; Hairong Huang; Babak Javid; Julian Parkhill; Sharon J Peacock; Claudio U Köser
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.