Young Mi Jung1, Seung Mi Lee1, Subeen Hong1, Ja Nam Koo2, Ig Hwan Oh2, Byoung Jae Kim1,3, Sun Min Kim1,3, Sang Youn Kim4, Gyoung Min Kim5, Sae Kyung Joo6,7, Sue Shin8,9, Errol R Norwitz10, Chan-Wook Park1, Jong Kwan Jun1, Won Kim6,7, Joong Shin Park1. 1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. 2. Seoul Women's Hospital, Incheon, Korea. 3. Department of Obstetrics and Gynecology, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, Korea. 4. Department of Radiology, Seoul National University College of Medicine, Seoul, Korea. 5. Department of Radiology, Yonsei University College of Medicine, Seoul, Korea. 6. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. 7. Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, Korea. 8. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea. 9. Department of Laboratory Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, Korea. 10. Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, MA, USA.
Abstract
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of cardiovascular disease (CVD) in non-pregnant adults. Although the biological mechanisms underlying this association are not completely understood, metabolic factors, inflammation, and endothelial dysfunction are likely all involved. The association between NAFLD and pregnancy-associated hypertension (HTN) has not been systematically examined. The aim of this study is to assess the risk of pregnancy-associated HTN in pregnant women with NAFLD. METHODS: This is secondary analysis of a prospective study of healthy pregnant women. Liver ultrasonography was performed at 10-14 weeks of gestation and maternal blood was taken for the measurement of selenoprotein P (SeP), a hepatokine independently associated with both NAFLD and CVD. Pregnancy-associated HTN was defined as the development of gestational HTN, preeclampsia, or eclampsia. RESULTS: Among 877 pregnant women, the risk of developing pregnancy-associated HTN was significantly increased in women with NAFLD compared to those without NAFLD. Grade 2-3 steatosis was a significant predictor of pregnancy-associated HTN, even after adjustment for metabolic risk factors. Circulating levels of SeP were significantly higher in women with versus those without NAFLD (P = .001) and was significantly higher also in women who subsequently developed pregnancy-associated HTN compared with those who did not (P < .005). CONCLUSIONS: Sonographic evidence of NAFLD at 10-14 weeks is an independent predictor of pregnancy-associated HTN. Circulating levels of SeP at that same gestational age are significantly increased in pregnant women with NAFLD who subsequently develop pregnancy-associated HTN.
BACKGROUND & AIMS:Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of cardiovascular disease (CVD) in non-pregnant adults. Although the biological mechanisms underlying this association are not completely understood, metabolic factors, inflammation, and endothelial dysfunction are likely all involved. The association between NAFLD and pregnancy-associated hypertension (HTN) has not been systematically examined. The aim of this study is to assess the risk of pregnancy-associated HTN in pregnant women with NAFLD. METHODS: This is secondary analysis of a prospective study of healthy pregnant women. Liver ultrasonography was performed at 10-14 weeks of gestation and maternal blood was taken for the measurement of selenoprotein P (SeP), a hepatokine independently associated with both NAFLD and CVD. Pregnancy-associated HTN was defined as the development of gestational HTN, preeclampsia, or eclampsia. RESULTS: Among 877 pregnant women, the risk of developing pregnancy-associated HTN was significantly increased in women with NAFLD compared to those without NAFLD. Grade 2-3 steatosis was a significant predictor of pregnancy-associated HTN, even after adjustment for metabolic risk factors. Circulating levels of SeP were significantly higher in women with versus those without NAFLD (P = .001) and was significantly higher also in women who subsequently developed pregnancy-associated HTN compared with those who did not (P < .005). CONCLUSIONS: Sonographic evidence of NAFLD at 10-14 weeks is an independent predictor of pregnancy-associated HTN. Circulating levels of SeP at that same gestational age are significantly increased in pregnant women with NAFLD who subsequently develop pregnancy-associated HTN.
Authors: Seung Mi Lee; Suhyun Hwangbo; Errol R Norwitz; Ja Nam Koo; Ig Hwan Oh; Eun Saem Choi; Young Mi Jung; Sun Min Kim; Byoung Jae Kim; Sang Youn Kim; Gyoung Min Kim; Won Kim; Sae Kyung Joo; Sue Shin; Chan-Wook Park; Taesung Park; Joong Shin Park Journal: Clin Mol Hepatol Date: 2021-10-15
Authors: Seung Mi Lee; Yonghyun Nam; Eun Saem Choi; Young Mi Jung; Vivek Sriram; Jacob S Leiby; Ja Nam Koo; Ig Hwan Oh; Byoung Jae Kim; Sun Min Kim; Sang Youn Kim; Gyoung Min Kim; Sae Kyung Joo; Sue Shin; Errol R Norwitz; Chan-Wook Park; Jong Kwan Jun; Won Kim; Dokyoon Kim; Joong Shin Park Journal: Sci Rep Date: 2022-09-22 Impact factor: 4.996