Lili Barsky1, C Noel Bairey Merz2, Janet Wei1, Chrisandra Shufelt1, Eileen Handberg3, Carl Pepine3, Thomas Rutledge4,5, Steven Reis6, Mark Doyle7, William Rogers8, Leslee Shaw9, George Sopko10. 1. Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, 127 S. San Vicente Blvd, Suite A3600, Los Angeles, CA, 90048, USA. 2. Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, 127 S. San Vicente Blvd, Suite A3600, Los Angeles, CA, 90048, USA. Noel.BaireyMerz@cshs.org. 3. Division of Cardiology, Department of Medicine, University of Florida, Gainesville, FL, USA. 4. VA San Diego Healthcare System, San Diego, CA, USA. 5. University of California, San Diego, CA, USA. 6. Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. 7. Division of Cardiology, Department of Medicine, Allegheny University of the Health Sciences, Pittsburgh, PA, USA. 8. Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. 9. Dalio Institute of Cardiovascular Imaging, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, NY, USA. 10. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Abstract
PURPOSE OF REVIEW: For over 20 years, the Women's Ischemia Syndrome Evaluation (WISE), a program sponsored by the National Heart, Lung, and Blood Institute, has explored diverse and important aspects of ischemic heart disease in women. RECENT FINDINGS: Women with symptoms and signs of ischemia but no significant epicardial obstructive coronary artery disease (INOCA) were documented to be at elevated risk for recurrent angina hospitalization, major adverse cardiac events, death, and health resource consumption rivaling those with obstructive coronary disease. WISE investigators have advanced our understanding of cardiovascular outcomes, systemic manifestations, psychological variables, socioeconomic factors, genetic contributions, hormonal status, advanced imaging, coronary functional findings, biomarkers, patient-reported outcomes, and treatments pertaining to women with this disease entity. This review delves into the WISE findings subsequent to a prior review1, postulates directions for future research, and asks are we "Even 'WISE-R?'".
PURPOSE OF REVIEW: For over 20 years, the Women's Ischemia Syndrome Evaluation (WISE), a program sponsored by the National Heart, Lung, and Blood Institute, has explored diverse and important aspects of ischemic heart disease in women. RECENT FINDINGS: Women with symptoms and signs of ischemia but no significant epicardial obstructive coronary artery disease (INOCA) were documented to be at elevated risk for recurrent angina hospitalization, major adverse cardiac events, death, and health resource consumption rivaling those with obstructive coronary disease. WISE investigators have advanced our understanding of cardiovascular outcomes, systemic manifestations, psychological variables, socioeconomic factors, genetic contributions, hormonal status, advanced imaging, coronary functional findings, biomarkers, patient-reported outcomes, and treatments pertaining to women with this disease entity. This review delves into the WISE findings subsequent to a prior review1, postulates directions for future research, and asks are we "Even 'WISE-R?'".
Authors: Lauren A Baldassarre; Subha V Raman; James K Min; Jennifer H Mieres; Martha Gulati; Nanette K Wenger; Thomas H Marwick; Chiara Bucciarelli-Ducci; C Noel Bairey Merz; Dipti Itchhaporia; Keith C Ferdinand; Carl J Pepine; Mary Norine Walsh; Jagat Narula; Leslee J Shaw Journal: JACC Cardiovasc Imaging Date: 2016-04
Authors: Mark Doyle; Gerald M Pohost; C Noel Bairey Merz; Leslee J Shaw; George Sopko; William J Rogers; Barry L Sharaf; Carl J Pepine; Diane A Vido-Thompson; Geetha Rayarao; Lindsey Tauxe; Sheryl F Kelsey; Douglas Mc Nair; Robert W Biederman Journal: Cardiovasc Diagn Ther Date: 2013-12
Authors: Gretchen L Gierach; B Delia Johnson; C Noel Bairey Merz; Sheryl F Kelsey; Vera Bittner; Marian B Olson; Leslee J Shaw; Sunil Mankad; Carl J Pepine; Steven E Reis; William J Rogers; Barry L Sharaf; George Sopko Journal: J Am Coll Cardiol Date: 2006-02-07 Impact factor: 24.094
Authors: Leslee J Shaw; Marian B Olson; Kevin Kip; Sheryl F Kelsey; B Delia Johnson; Daniel B Mark; Steven E Reis; Sunil Mankad; William J Rogers; Gerald M Pohost; Christopher B Arant; Timothy R Wessel; Bernard R Chaitman; George Sopko; Eileen Handberg; Carl J Pepine; C Noel Bairey Merz Journal: J Am Coll Cardiol Date: 2006-02-07 Impact factor: 24.094
Authors: Anthony A Bavry; Eileen M Handberg; Tianyao Huo; Amir Lerman; Arshed A Quyyumi; Chrisandra Shufelt; Barry Sharaf; C Noel Bairey Merz; Rhonda M Cooper-DeHoff; George Sopko; Carl J Pepine Journal: Am Heart J Date: 2014-03-01 Impact factor: 4.749
Authors: Wilmer W Nichols; Scott J Denardo; Jonathan B Davidson; Tianyao Huo; C Noel Bairey Merz; Carl J Pepine Journal: Am Heart J Date: 2015-08-28 Impact factor: 4.749
Authors: Liming Weng; Kent D Taylor; Yii-Der Ida Chen; George Sopko; Sheryl F Kelsey; C Noel Bairey Merz; Carl J Pepine; Virginia M Miller; Jerome I Rotter; Martha Gulati; Mark O Goodarzi; Rhonda M Cooper-DeHoff Journal: Physiol Genomics Date: 2015-11-03 Impact factor: 3.107
Authors: John W Petersen; B Delia Johnson; Kevin E Kip; R David Anderson; Eileen M Handberg; Barry Sharaf; Puja K Mehta; Sheryl F Kelsey; C Noel Bairey Merz; Carl J Pepine Journal: PLoS One Date: 2014-05-06 Impact factor: 3.240
Authors: Monica Parry; Harriette G C Van Spall; Kerri-Anne Mullen; Sharon L Mulvagh; Christine Pacheco; Tracey J F Colella; Marie-Annick Clavel; Shahin Jaffer; Heather J A Foulds; Jasmine Grewal; Marsha Hardy; Jennifer A D Price; Anna L E Levinsson; Christine A Gonsalves; Colleen M Norris Journal: CJC Open Date: 2022-04-19