B C Yoon1, M D Bulbul2, P M Sadow3,4, W C Faquin3,4, H D Curtin5, M A Varvares2, A F Juliano6. 1. From the Departments of Radiology (B.C.Y.). 2. Departments of Otolaryngology Head and Neck Surgery (M.D.B., M.A.V.). 3. Pathology (P.M.S., W.C.F.), Massachusetts General Hospital, Boston, Massachusetts. 4. Pathology (P.M.S., W.C.F.), Massachusetts Eye and Ear, Boston, Massachusetts. 5. Radiology (H.D.C., A.F.J.). 6. Radiology (H.D.C., A.F.J.) Amy_Juliano@meei.harvard.edu.
Abstract
BACKGROUND AND PURPOSE: For primary squamous cell carcinoma of the oral tongue, accurate assessment of tumor thickness and depth of invasion is critical for staging and operative management. Currently, typical imaging modalities used for preoperative staging are CT and MR imaging. Intraoperatively, CT or MR imaging cannot provide real-time guidance, and assessment by manual palpation is limited in precision. We investigated whether intraoperative sonography is a feasible technique for assessment of tumor thickness and depth of invasion and validated its accuracy by comparing it with histopathologic evaluation of the resected specimen. MATERIALS AND METHODS: Twenty-six patients with squamous cell carcinoma of the oral tongue who underwent tumor resection by a single surgeon between March 31, 2016, and April 26, 2019, were prospectively identified. Intraoperative sonography was obtained in planes longitudinal and transverse to the long axis of the tumor. Twenty-two patients had archived images that allowed measurements of tumor thickness and depth of invasion sonographically. Two patients had dysplasia and were excluded. The remaining 20 patients had histologic tumor thickness and histologic depth of invasion measured by a single pathologist. RESULTS: The mean sonographic tumor thickness was 7.5 ± 3.5 mm, and the mean histologic tumor thickness was 7.0 ± 4.2 mm. Mean sonographic depth of invasion and histologic depth of invasion were 6.6 ± 3.4 and 6.4 ± 4.4 mm, respectively. There was excellent correlation between sonographic and histologic measurements for both tumor thickness and depth of invasion with Pearson correlation coefficients of 0.95 (95% CI, 0.87-0.98) and 0.95 (95% CI, 0.87-0.98), respectively. CONCLUSIONS: Intraoperative sonography can provide reliable, real-time assessment of the extent of tongue tumors.
BACKGROUND AND PURPOSE: For primary squamous cell carcinoma of the oral tongue, accurate assessment of tumor thickness and depth of invasion is critical for staging and operative management. Currently, typical imaging modalities used for preoperative staging are CT and MR imaging. Intraoperatively, CT or MR imaging cannot provide real-time guidance, and assessment by manual palpation is limited in precision. We investigated whether intraoperative sonography is a feasible technique for assessment of tumor thickness and depth of invasion and validated its accuracy by comparing it with histopathologic evaluation of the resected specimen. MATERIALS AND METHODS: Twenty-six patients with squamous cell carcinoma of the oral tongue who underwent tumor resection by a single surgeon between March 31, 2016, and April 26, 2019, were prospectively identified. Intraoperative sonography was obtained in planes longitudinal and transverse to the long axis of the tumor. Twenty-two patients had archived images that allowed measurements of tumor thickness and depth of invasion sonographically. Two patients had dysplasia and were excluded. The remaining 20 patients had histologic tumor thickness and histologic depth of invasion measured by a single pathologist. RESULTS: The mean sonographic tumor thickness was 7.5 ± 3.5 mm, and the mean histologic tumor thickness was 7.0 ± 4.2 mm. Mean sonographic depth of invasion and histologic depth of invasion were 6.6 ± 3.4 and 6.4 ± 4.4 mm, respectively. There was excellent correlation between sonographic and histologic measurements for both tumor thickness and depth of invasion with Pearson correlation coefficients of 0.95 (95% CI, 0.87-0.98) and 0.95 (95% CI, 0.87-0.98), respectively. CONCLUSIONS: Intraoperative sonography can provide reliable, real-time assessment of the extent of tongue tumors.
Authors: S Shintani; Y Yoshihama; Y Ueyama; N Terakado; S Kamei; Y Fijimoto; Y Hasegawa; H Matsuura; T Matsumura Journal: Int J Oral Maxillofac Surg Date: 2001-04 Impact factor: 2.789
Authors: William M Lydiatt; Snehal G Patel; Brian O'Sullivan; Margaret S Brandwein; John A Ridge; Jocelyn C Migliacci; Ashley M Loomis; Jatin P Shah Journal: CA Cancer J Clin Date: 2017-01-27 Impact factor: 508.702
Authors: Mustafa G Bulbul; Osama Tarabichi; Rosh K Sethi; Anuraag S Parikh; Mark A Varvares Journal: Otolaryngol Head Neck Surg Date: 2019-03-26 Impact factor: 3.497
Authors: Osama Tarabichi; Vivek Kanumuri; Amy F Juliano; William C Faquin; Mary E Cunnane; Mark A Varvares Journal: Otolaryngol Head Neck Surg Date: 2017-11-21 Impact factor: 3.497
Authors: Rajan S Patel; David P Goldstein; Jennifer Guillemaud; Guillem Andreu Bruch; Dale Brown; Ralph W Gilbert; Patrick J Gullane; Kevin M Higgins; Jonathan Irish; Danny J Enepekides Journal: Head Neck Date: 2010-11 Impact factor: 3.147
Authors: Mohamed Elbarbary; Adam Sgro; Saber Khazaei; Michael Goldberg; Howard C Tenenbaum; Amir Azarpazhooh Journal: Clin Oral Investig Date: 2022-01-14 Impact factor: 3.573
Authors: Byung C Yoon; Karen Buch; Mary E Cunnane; Peter M Sadow; Mark A Varvares; Amy F Juliano Journal: Am J Otolaryngol Date: 2021-05-27 Impact factor: 2.873