Literature DB >> 3255368

The regions of alpha-neurotoxin binding on the extracellular part of the alpha-subunit of human acetylcholine receptor.

B Mulac-Jericevic1, T Manshouri, T Yokoi, M Z Atassi.   

Abstract

A set of 18 synthetic uniform overlapping peptides spanning the entire extracellular part (residues 1-210) of the alpha-subunit of human acetylcholine receptor were studied for their binding activity of 125I-labeled alpha-bungarotoxin and cobratoxin. A major toxin-binding region was found to reside within peptide alpha 122-138. In addition, low-binding activities were obtained with peptides alpha 34-49 and alpha 194-210. It is concluded that the region within residues alpha 122-138 constitutes a universal major toxin-binding region for acetylcholine receptor of various species.

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Year:  1988        PMID： 3255368     DOI： 10.1007/bf01025247

Source DB:  PubMed          Journal:  J Protein Chem        ISSN： 0277-8033


  14 in total

Review 1.  The molecular neurobiology of the acetylcholine receptor.

Authors:  M P McCarthy; J P Earnest; E F Young; S Choe; R M Stroud
Journal:  Annu Rev Neurosci       Date:  1986       Impact factor: 12.449

2.  A novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the alpha-chain of human haemoglobin.

Authors:  A L Kazim; M Z Atassi
Journal:  Biochem J       Date:  1980-10-01       Impact factor: 3.857

Review 3.  Acetylcholine receptor: an allosteric protein.

Authors:  J P Changeux; A Devillers-Thiéry; P Chemouilli
Journal:  Science       Date:  1984-09-21       Impact factor: 47.728

Review 4.  The nicotinic cholinergic receptor: correlation of molecular structure with functional properties.

Authors:  B M Conti-Tronconi; M A Raftery
Journal:  Annu Rev Biochem       Date:  1982       Impact factor: 23.643

5.  Comparison of the subunits of Torpedo californica acetylcholine receptor by peptide mapping.

Authors:  S C Froehner; S Rafto
Journal:  Biochemistry       Date:  1979-01-23       Impact factor: 3.162

6.  Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor.

Authors:  M Noda; Y Furutani; H Takahashi; M Toyosato; T Tanabe; S Shimizu; S Kikyotani; T Kayano; T Hirose; S Inayama
Journal:  Nature       Date:  1983 Oct 27-Nov 2       Impact factor: 49.962

7.  Studies of reversible and irreversible interactions of an alkylating agonist with Torpedo californica acetylcholine receptor in membrane-bound and purified states.

Authors:  H P Moore; M A Raftery
Journal:  Biochemistry       Date:  1979-05-15       Impact factor: 3.162

8.  Segment alpha 182-198 of Torpedo californica acetylcholine receptor contains second toxin-binding region and binds anti-receptor antibodies.

Authors:  B Mulac-Jericevic; M Z Atassi
Journal:  FEBS Lett       Date:  1986-04-07       Impact factor: 4.124

9.  High affinity binding of alpha-bungarotoxin to the purified alpha-subunit and to its 27,000-dalton proteolytic peptide from Torpedo marmorata acetylcholine receptor. Requirement for sodium dodecyl sulfate.

Authors:  S J Tzartos; J P Changeux
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  10 in total

1.  Localization and synthesis of an insulin-binding region on human insulin receptor.

Authors:  S Nakamura; S Sakata; M Z Atassi
Journal:  J Protein Chem       Date:  1990-04

2.  Acetylcholine receptor-alpha-bungarotoxin interactions: determination of the region-to-region contacts by peptide-peptide interactions and molecular modeling of the receptor cavity.

Authors:  K H Ruan; J Spurlino; F A Quiocho; M Z Atassi
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

3.  Mapping by synthetic peptides of the binding sites for acetylcholine receptor on alpha-bungarotoxin.

Authors:  M Z Atassi; C S McDaniel; T Manshouri
Journal:  J Protein Chem       Date:  1988-10

4.  Seventh International Conference on Methods in Protein Sequence Analysis. July 3-8, 1988, West Berlin, F.R.G. Short communications.

Authors: 
Journal:  J Protein Chem       Date:  1988-06

5.  Analysis of exposed regions on the main extracellular domain of mouse acetylcholine receptor alpha subunit in live muscle cells by binding profiles of antipeptide antibodies.

Authors:  K Jinnai; T Ashizawa; M Z Atassi
Journal:  J Protein Chem       Date:  1994-11

6.  Mapping the extracellular topography of the alpha-chain in free and in membrane-bound acetylcholine receptor by antibodies against overlapping peptides spanning the entire extracellular parts of the chain.

Authors:  M Z Atassi; B Mulac-Jericevic
Journal:  J Protein Chem       Date:  1994-01

7.  10th International Conference on Methods in Protein Structure Analysis. September 8-13, 1994, Snowbird, Utah. Short communications and abstracts.

Authors: 
Journal:  J Protein Chem       Date:  1994-07

8.  Interaction of synthetic peptides from fasciculin with acetylcholinesterase.

Authors:  R J Falkenstein; C Peña
Journal:  J Protein Chem       Date:  1999-02

9.  The short-neurotoxin-binding regions on the alpha-chain of human and Torpedo californica acetylcholine receptors.

Authors:  K H Ruan; B G Stiles; M Z Atassi
Journal:  Biochem J       Date:  1991-03-15       Impact factor: 3.857

10.  Localization and synthesis of the hormone-binding regions of the human thyrotropin receptor.

Authors:  M Z Atassi; T Manshouri; S Sakata
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205
  10 in total

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