Literature DB >> 32540644

The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.

Zhonghua Zheng1, Yin Li1, Gehui Jin1, Tianyi Huang1, Mengsha Zou1, Shiwei Duan2.   

Abstract

ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated fatty acid substrates to produce biologically active lipid mediators including eicosanes and lipoxins. ALOX12 protein plays an important role in inflammation and oxidation, while abnormal DNA methylation and genetic variants of ALOX12 are associated with various human diseases and pathological phenotypes, such as cardiovascular disease, diabetes, neurodegenerative diseases, respiratory system disease, cancer, infection, etc. Here, this article reviews the mechanisms by which ALOX12 participates in related diseases, which will provide systematic knowledge for future ALOX12 related studies.
Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Entities:  

Keywords:  Arachidonate 12-lipoxygenase; Diseases; Inflammation; Single nucleotide polymorphism

Year:  2020        PMID： 32540644     DOI： 10.1016/j.biopha.2020.110354

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


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