Literature DB >> 32537708

Synthesis of tetracyclic pyrido-fused dibenzodiazepines via a catalyst-free cascade reaction.

Abdolali Alizadeh1, Akram Bagherinejad2.   

Abstract

An efficient, eco-friendly protocol has been described for the chemoselective synthesis of tetracyclic pyrido-fused dibenzodiazepines derivatives via catalyst-free, three-component reaction of dimedone, 1,2-diamines, 3-formylchromones, and malononitrile. The significant advantages of this cascade approach are to create two new rings and four new σ bonds containing three C-N and one C-C bond, as well as the breakdown of a C-O bond.
© 2020. Springer Nature Switzerland AG.

Entities:  

Keywords:  Catalyst free; Chemoselective; Dibenzo[b,f]pyrido[1,2-d][1,4]diazepine; Enaminone; Knoevenagel condensation; Seven-membered ring; Tetracyclic ring; Three-component cascade reaction

Mesh：

Substances：

Year:  2020        PMID： 32537708     DOI： 10.1007/s11030-020-10114-1

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


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