| Literature DB >> 32536210 |
Ricson Pemimpin Hutagaol1,2, Desi Harneti1, Agus Safari1, Ace Tatang Hidayat1,3, Unang Supratman1,3, Khalijah Awang4, Yoshihito Shiono5.
Abstract
A seco-apotirucallane-type triterpenoid, namely angustifolianin (1), along with three dammarane-type triterpenoids, (20S, 24S)-epoxy-dammarane-3β,25-diol (2), 3-epi-cabraleahydroxylactone (3), and cabralealactone (4), were isolated from the stem bark of Aglaia angustifolia Miq. The Chemical structure of the new compounds was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells. Among those compounds, angustifolianin (1) showed strongest cytotoxic activity with an IC50 value of 50.5 μg/ml.Entities:
Keywords: Aglaia angustifolia; MCF-7; Meliaceae; angustifolianin; seco-apotirucallane
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Year: 2020 PMID： 32536210 DOI： 10.1080/10286020.2020.1776704
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569