Chengqian Yin1, Bo Zhu2, Xin Li2, Colin R Goding3, Rutao Cui4. 1. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: yincq323@gmail.com. 2. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA. 3. Ludwig Institute for Cancer Research, University of Oxford, Headington, Oxford OX3 7DQ, UK. 4. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: rutaocui@bu.edu.