Qinnan Wang1, Dongjuan Yu2, Jiajun Wang3, Shaohui Lin4. 1. Department of Orthopaedics and Traumatology, Weihai Hospital of Traditional Chinese Medicine, Weihai, China. 2. Department of Anesthesiology, Weihai Hospital of Traditional Chinese Medicine, Weihai, China. 3. Department of Orthopedics, Wenkou Hospital of Qixia, Qixia, China. 4. Department of Geriatrics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. shenhui1030@163.com.
Abstract
BACKGROUND: Vitamin D deficiency can lead to osteoporosis and increases the risk of fractures. Vitamin D deficiency is prevalent in Asian populations, however, research focusing on the association between vitamin D deficiency and osteoporotic hip fractures, particularly in Chinese populations is scarce. The aim of this study was to explore the relationship between vitamin D deficiency and osteoporotic hip fractures in elderly Chinese patients. METHODS: This cross-sectional study recruited 60 patients (aged 65 years and over) who had hip fractures. Serum 25-hydroxyvitamin D (25OHD) levels were examined using an electrochemiluminescence immunoassay. The patients were classified into two groups based on their bone mineral density (BMD); subjects with osteoporosis (BMD t value ≤-2.5) and individuals without osteoporosis (BMD t value ≥-1.0). Serum 25OHD was further analyzed in these two groups. RESULTS: Across all of the patients with hip fractures, approximately 10% showed vitamin D deficiency, and a further 53.33% showed vitamin D. insufficiency. Furthermore, of the patients with hip fractures, those with osteoporosis had significantly lower levels of serum 25OHD (25.43±6.35 ng/mL) compared to those patients without osteoporosis (30.70±7.17 ng/mL). The incidence of vitamin D insufficiency (66.67%) and deficiency (16.67%) was higher in the patients with osteoporosis than in those without osteoporosis (insufficiency 44.44% and deficiency 5.56%, respectively). CONCLUSIONS: Our study confirmed a high prevalence of vitamin D insufficiency in elderly patients with hip fractures in China. Our data suggests that vitamin D plays an important role in the occurrence of hip fractures in these elderly patients, and especially where patients also suffer from osteoporosis.
BACKGROUND:Vitamin D deficiency can lead to osteoporosis and increases the risk of fractures. Vitamin D deficiency is prevalent in Asian populations, however, research focusing on the association between vitamin Ddeficiency and osteoporotic hip fractures, particularly in Chinese populations is scarce. The aim of this study was to explore the relationship between vitamin Ddeficiency and osteoporotic hip fractures in elderly Chinese patients. METHODS: This cross-sectional study recruited 60 patients (aged 65 years and over) who had hip fractures. Serum 25-hydroxyvitamin D (25OHD) levels were examined using an electrochemiluminescence immunoassay. The patients were classified into two groups based on their bone mineral density (BMD); subjects with osteoporosis (BMD t value ≤-2.5) and individuals without osteoporosis (BMD t value ≥-1.0). Serum 25OHD was further analyzed in these two groups. RESULTS: Across all of the patients with hip fractures, approximately 10% showed vitamin D deficiency, and a further 53.33% showed vitamin D. insufficiency. Furthermore, of the patients with hip fractures, those with osteoporosis had significantly lower levels of serum 25OHD (25.43±6.35 ng/mL) compared to those patients without osteoporosis (30.70±7.17 ng/mL). The incidence of vitamin Dinsufficiency (66.67%) and deficiency (16.67%) was higher in the patients with osteoporosis than in those without osteoporosis (insufficiency 44.44% and deficiency 5.56%, respectively). CONCLUSIONS: Our study confirmed a high prevalence of vitamin Dinsufficiency in elderly patients with hip fractures in China. Our data suggests that vitamin D plays an important role in the occurrence of hip fractures in these elderly patients, and especially where patients also suffer from osteoporosis.
Entities:
Keywords:
Vitamin D insufficiency; aging population; hip fracture; osteoporosis
Authors: Amal Abdul Rahim Al Zarooni; Nico Nagelkerke; Fatima Ibrahim Al Marzouqi; Salma Hamad Al Darmaki Journal: PLoS One Date: 2022-02-15 Impact factor: 3.240