Literature DB >> 32527097

How to Stimulate and Facilitate Early Stage Antibiotic Discovery.

Johannes Zuegg1, Karl A Hansford1, Alysha G Elliott1, Matthew A Cooper1, Mark A T Blaskovich1.   

Abstract

The discovery of novel antibiotics is essential to combat the rise of antimicrobial resistance. While a number of initiatives are focused on advancing promising leads into the clinic, there is a dearth of effort at stimulating the early stage discovery. We present one pathway that has successfully demonstrated an ability to revitalize fundamental research and reengage researchers.

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Year:  2020        PMID： 32527097     DOI： 10.1021/acsinfecdis.0c00163

Source DB:  PubMed          Journal:  ACS Infect Dis        ISSN： 2373-8227            Impact factor:   5.084


  9 in total

1.  An interpretable machine learning approach to identify mechanism of action of antibiotics.

Authors:  Mihir Mongia; Mustafa Guler; Hosein Mohimani
Journal:  Sci Rep       Date:  2022-06-20       Impact factor: 4.996

2.  Platinum Cyclooctadiene Complexes with Activity against Gram-positive Bacteria.

Authors:  Angelo Frei; Soumya Ramu; Gabrielle J Lowe; Hue Dinh; Lucie Semenec; Alysha G Elliott; Johannes Zuegg; Anke Deckers; Nicole Jung; Stefan Bräse; Amy K Cain; Mark A T Blaskovich
Journal:  ChemMedChem       Date:  2021-07-08       Impact factor: 3.540

Review 3.  Towards the sustainable discovery and development of new antibiotics.

Authors:  Marcus Miethke; Marco Pieroni; Tilmann Weber; Mark Brönstrup; Peter Hammann; Ludovic Halby; Paola B Arimondo; Philippe Glaser; Bertrand Aigle; Helge B Bode; Rui Moreira; Yanyan Li; Andriy Luzhetskyy; Marnix H Medema; Jean-Luc Pernodet; Marc Stadler; José Rubén Tormo; Olga Genilloud; Andrew W Truman; Kira J Weissman; Eriko Takano; Stefano Sabatini; Evi Stegmann; Heike Brötz-Oesterhelt; Wolfgang Wohlleben; Myriam Seemann; Martin Empting; Anna K H Hirsch; Brigitta Loretz; Claus-Michael Lehr; Alexander Titz; Jennifer Herrmann; Timo Jaeger; Silke Alt; Thomas Hesterkamp; Mathias Winterhalter; Andrea Schiefer; Kenneth Pfarr; Achim Hoerauf; Heather Graz; Michael Graz; Mika Lindvall; Savithri Ramurthy; Anders Karlén; Maarten van Dongen; Hrvoje Petkovic; Andreas Keller; Frédéric Peyrane; Stefano Donadio; Laurent Fraisse; Laura J V Piddock; Ian H Gilbert; Heinz E Moser; Rolf Müller
Journal:  Nat Rev Chem       Date:  2021-08-19       Impact factor: 34.571

4.  AB-DB: Force-Field parameters, MD trajectories, QM-based data, and Descriptors of Antimicrobials.

Authors:  Silvia Gervasoni; Giuliano Malloci; Andrea Bosin; Attilio V Vargiu; Helen I Zgurskaya; Paolo Ruggerone
Journal:  Sci Data       Date:  2022-04-01       Impact factor: 6.444

5.  Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria.

Authors:  Dominik Gurvic; Andrew G Leach; Ulrich Zachariae
Journal:  J Med Chem       Date:  2022-04-15       Impact factor: 8.039

6.  N-Alkyl-2-Quinolonopyrones Demonstrate Antimicrobial Activity against ESKAPE Pathogens Including Staphylococcus aureus.

Authors:  Eoin Moynihan; Katrina Mackey; Mark A T Blaskovich; F Jerry Reen; Gerard McGlacken
Journal:  ACS Med Chem Lett       Date:  2022-07-19       Impact factor: 4.632

Review 7.  Open science approaches to COVID-19.

Authors:  Edwin G Tse; Dana M Klug; Matthew H Todd
Journal:  F1000Res       Date:  2020-08-25

8.  Multi-Institution Research and Education Collaboration Identifies New Antimicrobial Compounds.

Authors:  Amelia A Fuller; Amy B Dounay; Douglas Schirch; Daniel G Rivera; Karl A Hansford; Alysha G Elliott; Johannes Zuegg; Matthew A Cooper; Mark A T Blaskovich; Jacob R Hitchens; Sarah Burris-Hiday; Kristiana Tenorio; Yanira Mendez; J Geno Samaritoni; Martin J O'Donnell; William L Scott
Journal:  ACS Chem Biol       Date:  2020-11-26       Impact factor: 5.100

9.  There is no market for new antibiotics: this allows an open approach to research and development.

Authors:  Dana M Klug; Fahima I M Idiris; Mark A T Blaskovich; Frank von Delft; Christopher G Dowson; Claas Kirchhelle; Adam P Roberts; Andrew C Singer; Matthew H Todd
Journal:  Wellcome Open Res       Date:  2021-06-11
  9 in total

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