Mustafa Ibrahim1,2, Khaled Meknas3,4, Sonja E Steigen5,6, Randi Olsen7, Ninni Sernert8,9, Lars Ejerhed8,9, Jüri-Toomas Kartus10,8,9. 1. Department of Orthopedics, NU Hospital Group, Trollhättan, Sweden. mustafa.ibrahim.ahmad@vgregion.se. 2. Institution of Clinical Science, Sahlgrenska Academy, Gothenburg, Sweden. mustafa.ibrahim.ahmad@vgregion.se. 3. Department of Orthopedics, University Hospital North Norway, Tromsø, Norway. 4. Orthopedics Research Group, Institute of Clinical Medicine, The Arctic University of Norway, Tromsø, Norway. 5. Diagnostic Clinic-Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway. 6. Institute of Medical Biology, Faculty of Health Sciences, The Arctic University of Norway, Tromsø, Norway. 7. Advanced Microscopy Core Facility, Institute of Medical Biology, UIT-The Arctic University of Norway, Tromsø, Norway. 8. Institution of Clinical Science, Sahlgrenska Academy, Gothenburg, Sweden. 9. Department of Research and Development, NU Hospital Group, Trollhättan, Sweden. 10. Department of Orthopedics, NU Hospital Group, Trollhättan, Sweden.
Abstract
PURPOSE: To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA. METHODS: Samples from 41 patients were included between January 2016 and October 2017. Twenty-one patients median age 53 (33-63) years with mild to moderate OA underwent high tibial osteotomy (HTO) and 20 patients median age 38 (31-57) years without OA underwent anterior cruciate ligament reconstruction (ACLR). Biopsies from the semitendinosus tendon were obtained at the time of surgery and examined histologically, morphologically and ultrastructurally using light and electron microscope. RESULTS: The histological evaluation of the semitendinosus tendon revealed the presence of more hemosiderin in the ACLR group. No significant morphological or ultrastructural differences were shown between patients in the HTO and ACLR group. CONCLUSION: Patients with mild and moderate medial compartment knee OA displayed no more degenerative changes in their semitendinosus tendon than patients without OA, as seen in both the light and the electron microscope. LEVEL OF EVIDENCE: III.
PURPOSE: To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA. METHODS: Samples from 41 patients were included between January 2016 and October 2017. Twenty-one patients median age 53 (33-63) years with mild to moderate OA underwent high tibial osteotomy (HTO) and 20 patients median age 38 (31-57) years without OA underwent anterior cruciate ligament reconstruction (ACLR). Biopsies from the semitendinosus tendon were obtained at the time of surgery and examined histologically, morphologically and ultrastructurally using light and electron microscope. RESULTS: The histological evaluation of the semitendinosus tendon revealed the presence of more hemosiderin in the ACLR group. No significant morphological or ultrastructural differences were shown between patients in the HTO and ACLR group. CONCLUSION:Patients with mild and moderate medial compartment knee OA displayed no more degenerative changes in their semitendinosus tendon than patients without OA, as seen in both the light and the electron microscope. LEVEL OF EVIDENCE: III.