Mustafa Ibrahim1,2, Jüri-Toomas Kartus1,2, Sonja Eriksson Steigen3,4, Randi Olsen5, Khaled Meknas6,7. 1. Department of Orthopedics, NU-Hospital Group, Trollhättan/Uddevalla, Sweden. 2. University of Gothenburg Sweden, Gothenburg, Sweden. 3. Diagnostic Clinic, Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway. 4. Institute of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. 5. Department of Electron Microscopy, Institute of Medical Biology, University of Tromsø, Tromsø, Norway. 6. Department of Orthopedics, University Hospital North Norway, 9038, Tromsø, Norway. khaled.meknas@uit.no. 7. Orthopedics Research Group, Institute of Clinical Medicine, The Arctic University of Norway, 9037, Tromsø, Norway. khaled.meknas@uit.no.
Abstract
PURPOSE: Tendon disorders are a major problem in the general population. It is known that rotator cuff tendinopathy contributes to osteoarthritis (OA) of the shoulder. The aim of the study was to analyse the presence of tendinopathy in patients with shoulder OA and an intact rotator cuff, using a multimodal approach. METHODS: Thirteen consecutive patients median age 67 (52-84) years, with OA of the shoulder, and 13 consecutive control patients, with a fracture of the proximal humerus, median age 70 (51-84) years, underwent an open biopsy procedure from the biceps and subscapularis tendon in conjunction with shoulder arthroplasty. In addition to a macroscopic evaluation, the samples underwent histologic, morphologic and ultrastructural analyses in light and transmission electron microscopy. RESULTS: Macroscopic degeneration was found in 15 of 26 specimen in the OA group but in seven of 25 in the control group (p = 0.048). The histologic analysis revealed a non-significant difference for the total degeneration score (TDS) between the study groups. The morphologic evaluation of the samples revealed that the OA group had significantly more samples with non-homogeneous extracellular matrix (ECM), (p = 0.048). Ultrastructurally, the OA group revealed a significantly larger fibril diameter in the biceps tendon (p < 0.0001) but not in the subscapularis tendon compared with the control group. CONCLUSION: A significantly worse macroscopic appearance and significantly more morphologically inhomogeneous ECM, indicating more tendon degeneration, were found in the OA group compared with the control group. This indicates that it could be beneficial to treat the tendinosis in an early stage to decrease symptoms from the OA. STUDY DESIGN: Level of evidence, III.
PURPOSE:Tendon disorders are a major problem in the general population. It is known that rotator cuff tendinopathy contributes to osteoarthritis (OA) of the shoulder. The aim of the study was to analyse the presence of tendinopathy in patients with shoulder OA and an intact rotator cuff, using a multimodal approach. METHODS: Thirteen consecutive patients median age 67 (52-84) years, with OA of the shoulder, and 13 consecutive control patients, with a fracture of the proximal humerus, median age 70 (51-84) years, underwent an open biopsy procedure from the biceps and subscapularis tendon in conjunction with shoulder arthroplasty. In addition to a macroscopic evaluation, the samples underwent histologic, morphologic and ultrastructural analyses in light and transmission electron microscopy. RESULTS: Macroscopic degeneration was found in 15 of 26 specimen in the OA group but in seven of 25 in the control group (p = 0.048). The histologic analysis revealed a non-significant difference for the total degeneration score (TDS) between the study groups. The morphologic evaluation of the samples revealed that the OA group had significantly more samples with non-homogeneous extracellular matrix (ECM), (p = 0.048). Ultrastructurally, the OA group revealed a significantly larger fibril diameter in the biceps tendon (p < 0.0001) but not in the subscapularis tendon compared with the control group. CONCLUSION: A significantly worse macroscopic appearance and significantly more morphologically inhomogeneous ECM, indicating more tendon degeneration, were found in the OA group compared with the control group. This indicates that it could be beneficial to treat the tendinosis in an early stage to decrease symptoms from the OA. STUDY DESIGN: Level of evidence, III.
Authors: Zhenhong Ni; Siru Zhou; Song Li; Liang Kuang; Hangang Chen; Xiaoqing Luo; Junjie Ouyang; Mei He; Xiaolan Du; Lin Chen Journal: Bone Res Date: 2020-06-19 Impact factor: 13.567
Authors: Zhenhong Ni; Siru Zhou; Song Li; Liang Kuang; Hangang Chen; Xiaoqing Luo; Junjie Ouyang; Mei He; Xiaolan Du; Lin Chen Journal: Bone Res Date: 2020-06-19 Impact factor: 13.567
Authors: Fabian Plachel; Philipp Moroder; Renate Gehwolf; Herbert Tempfer; Andrea Wagner; Alexander Auffarth; Nicholas Matis; Stephan Pauly; Mark Tauber; Andreas Traweger Journal: J Orthop Res Date: 2019-06-25 Impact factor: 3.494
Authors: Carly A Lockard; Philip-C Nolte; Karissa M B Gawronski; Bryant P Elrick; Brandon T Goldenberg; Marilee P Horan; Grant J Dornan; Charles P Ho; Peter J Millett Journal: Eur J Radiol Open Date: 2021-02-13
Authors: James Johnson; Devin von Stade; Daniel Regan; Jeremiah Easley; Lyndah Chow; Steven Dow; Tony Romeo; Ted Schlegel; Kirk McGilvray Journal: Ann Transl Med Date: 2021-11
Authors: James Johnson; Devin von Stade; Daniel Regan; Jeremiah Easley; Lyndah Chow; Steven Dow; Tony Romeo; Ted Schlegel; Kirk McGilvray Journal: Ann Transl Med Date: 2021-05