Zoe Mestre1,2, Amanda Bischoff-Grethe2, Christina E Wierenga2,3, Terry Jernigan4, Dawn M Eichen5, Linda Chang6,7,8, Thomas Ernst6,8, Kerri N Boutelle2,5,9. 1. San Diego State University-University of California San Diego Joint Doctoral Program in Clinical Psychology, UCSD Center for Healthy Eating and Activity Research (CHEAR), La Jolla, California, USA. 2. Department of Psychiatry, University of California San Diego, La Jolla, California, USA. 3. Veterans Affairs San Diego Healthcare System, Research Service, San Diego, California, USA. 4. Department of Cognitive Science, University of California San Diego, La Jolla, California, USA. 5. Department of Pediatrics, University of California San Diego, La Jolla, California, USA. 6. Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medecine, Baltimore, Maryland, USA. 7. Departrment of Neurology, University of Maryland School of Medecine, Baltimore, Maryland, USA. 8. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 9. Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA.
Abstract
OBJECTIVE: The hippocampus is a key structure in feeding behaviors and weight regulation. Obesity may lead to disruptions in hippocampal structure. In animals, obesity-related factors (e.g., high-fat/sugar foods) are associated with hippocampal insult (e.g., alterations in the blood brain barrier). In humans, individuals with obesity, relative to healthy weight, have smaller hippocampal volumes. Few studies have examined the association between body weight and the hippocampus during adolescence, a critical brain development period. This study examined hippocampal volume and tissue signal intensity in adolescents across the weight spectrum. METHODS: Structural magnetic resonance imaging and anthropomorphic data were available for 102 12- to 18-year-old adolescents (53% female; 15.07 [SD 1.84] years; standardized BMI [BMIz] scores using the Centers for Disease Control and Prevention growth charts: 0.54 [SD 1.17]) from the Pediatric Imaging, Neurocognition, and Genetics database. Linear regression models controlling for age, sex, genetic ancestry, scanner, and household income examined the relationship between BMIz, hippocampal volume, and T2-weighted hippocampal signal intensity. RESULTS: BMIz was negatively associated with T2-weighted hippocampal signal intensity in the left (t = -3.05; P = 0.003; r = -0.21) and right (t = -2.50; P = 0.01; r = -0.36) hippocampi. BMIz was not significantly associated with hippocampal volume. CONCLUSIONS: BMIz is associated with hippocampal tissue characteristics during adolescence, which could impact later brain development.
OBJECTIVE: The hippocampus is a key structure in feeding behaviors and weight regulation. Obesity may lead to disruptions in hippocampal structure. In animals, obesity-related factors (e.g., high-fat/sugar foods) are associated with hippocampal insult (e.g., alterations in the blood brain barrier). In humans, individuals with obesity, relative to healthy weight, have smaller hippocampal volumes. Few studies have examined the association between body weight and the hippocampus during adolescence, a critical brain development period. This study examined hippocampal volume and tissue signal intensity in adolescents across the weight spectrum. METHODS: Structural magnetic resonance imaging and anthropomorphic data were available for 102 12- to 18-year-old adolescents (53% female; 15.07 [SD 1.84] years; standardized BMI [BMIz] scores using the Centers for Disease Control and Prevention growth charts: 0.54 [SD 1.17]) from the Pediatric Imaging, Neurocognition, and Genetics database. Linear regression models controlling for age, sex, genetic ancestry, scanner, and household income examined the relationship between BMIz, hippocampal volume, and T2-weighted hippocampal signal intensity. RESULTS:BMIz was negatively associated with T2-weighted hippocampal signal intensity in the left (t = -3.05; P = 0.003; r = -0.21) and right (t = -2.50; P = 0.01; r = -0.36) hippocampi. BMIz was not significantly associated with hippocampal volume. CONCLUSIONS:BMIz is associated with hippocampal tissue characteristics during adolescence, which could impact later brain development.
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