Literature DB >> 10619628

Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases.

Y L Chung1, A Williams, D Ritchie, S C Williams, K K Changani, J Hope, J D Bell.   

Abstract

Magnetic resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and hyper-intense changes in the conventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data.

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Year:  1999        PMID： 10619628     DOI： 10.1097/00001756-199911260-00002

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  18 in total

1.  Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt disease.

Authors:  Michael D Geschwind; Christopher A Potter; Mamta Sattavat; Paul A Garcia; Howard J Rosen; Bruce L Miller; Stephen J DeArmond
Journal:  Alzheimer Dis Assoc Disord       Date:  2009 Jan-Mar       Impact factor: 2.703

2.  Creutzfeldt-Jakob disease: case discussion and imaging review.

Authors:  Cory Morgan; Manu Gupta; Waleed El-Feky; Sadat Shamim; Michael Opatowsky
Journal:  Proc (Bayl Univ Med Cent)       Date:  2009-01

3.  Obesity is associated with hypothalamic injury in rodents and humans.

Authors:  Joshua P Thaler; Chun-Xia Yi; Ellen A Schur; Stephan J Guyenet; Bang H Hwang; Marcelo O Dietrich; Xiaolin Zhao; David A Sarruf; Vitaly Izgur; Kenneth R Maravilla; Hong T Nguyen; Jonathan D Fischer; Miles E Matsen; Brent E Wisse; Gregory J Morton; Tamas L Horvath; Denis G Baskin; Matthias H Tschöp; Michael W Schwartz
Journal:  J Clin Invest       Date:  2011-12-27       Impact factor: 14.808

4.  Associations Between Body Weight, Hippocampal Volume, and Tissue Signal Intensity in 12- to 18-Year-Olds.

Authors:  Zoe Mestre; Amanda Bischoff-Grethe; Christina E Wierenga; Terry Jernigan; Dawn M Eichen; Linda Chang; Thomas Ernst; Kerri N Boutelle
Journal:  Obesity (Silver Spring)       Date:  2020-06-05       Impact factor: 5.002

5.  Longer T(2) relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity.

Authors:  Donghoon Lee; Joshua P Thaler; Kathryn E Berkseth; Susan J Melhorn; Michael W Schwartz; Ellen A Schur
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-04-02       Impact factor: 4.310

Review 6.  Radiological assessment of Creutzfeldt-Jakob disease.

Authors:  Henriette J Tschampa; Inga Zerr; Horst Urbach
Journal:  Eur Radiol       Date:  2006-11-09       Impact factor: 5.315

7.  Heidenhain variant of Creutzfeldt-Jakob disease: An autopsy study from India.

Authors:  Monica Kher; Medha Y Rao; P T Acharya; Anita Mahadevan; S K Shankar
Journal:  Ann Indian Acad Neurol       Date:  2009-01       Impact factor: 1.383

8.  Extensive cortical damage in a case of Creutzfeldt-Jacob disease: clinicoradiological correlations.

Authors:  M Bergui; G B Bradac; G Rossi; L Orsi
Journal:  Neuroradiology       Date:  2003-03-18       Impact factor: 2.804

9.  Thalamic involvement in sporadic Creutzfeldt-Jakob disease: a diffusion-weighted MR imaging study.

Authors:  Henriette J Tschampa; Petra Mürtz; Sebastian Flacke; Sebastian Paus; Hans H Schild; Horst Urbach
Journal:  AJNR Am J Neuroradiol       Date:  2003-05       Impact factor: 3.825

10.  Isolated cortical signal increase on MR imaging as a frequent lesion pattern in sporadic Creutzfeldt-Jakob disease.

Authors:  B Meissner; K Kallenberg; P Sanchez-Juan; A Krasnianski; U Heinemann; D Varges; M Knauth; I Zerr
Journal:  AJNR Am J Neuroradiol       Date:  2008-07-03       Impact factor: 3.825
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