Literature DB >> 32500008

Towards a Clinically Valid Mechanistic Assessment of Exposure and Response Prevention: Preliminary Utility of an Exposure Learning Tool for Children with OCD.

Jennie M Kuckertz1,2, John Piacentini3, Nader Amir1.   

Abstract

Despite advances in understanding mechanisms underlying fear processes, there remains a significant gap between insights produced via laboratory assessment and concrete tools for harnessing these insights in clinical practice. In addressing this gap, researchers would ideally introduce tools that are feasible for patients in clinical practice, easily disseminated to practitioners, and clinically useful. We present pilot data on the Exposure Experience Questionnaire (EEQ), a brief measure designed to assess exposure learning mechanisms. Ten children (ages 8-15) with a primary diagnosis of obsessive-compulsive disorder (OCD) underwent exposure and response prevention in which they completed weekly exposures in clinic and at home. During each exposure, children completed an exposure practice form which included the EEQ. Results suggest the preliminary feasibility and internal consistency of this measure, with comparable utility in clinic and home settings. The EEQ was associated in the expected direction with slope of OCD symptoms, such that greater exposure learning in both clinic and homework exposures predicted improved outcome. Although limited by small sample size, these data support the continued research on the feasibility and utility of the EEQ and suggest that quantifying learning processes following exposure may be a useful addition to mechanistic research in OCD.

Entities:  

Keywords:  children; exposure and response prevention; inhibitory learning; mechanisms; obsessive compulsive disorder

Year:  2020        PMID: 32500008      PMCID: PMC7271823          DOI: 10.1016/j.jocrd.2020.100528

Source DB:  PubMed          Journal:  J Obsessive Compuls Relat Disord        ISSN: 2211-3649            Impact factor:   1.677


  45 in total

1.  Whither Research Domain Criteria (RDoC)?: The Good, the Bad, and the Ugly.

Authors:  Daniel R Weinberger; Ira D Glick; Donald F Klein
Journal:  JAMA Psychiatry       Date:  2015-12       Impact factor: 21.596

2.  Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortex.

Authors:  Francisco Sotres-Bayon; Christopher K Cain; Joseph E LeDoux
Journal:  Biol Psychiatry       Date:  2006-01-17       Impact factor: 13.382

Review 3.  Optimizing inhibitory learning during exposure therapy.

Authors:  Michelle G Craske; Katharina Kircanski; Moriel Zelikowsky; Jayson Mystkowski; Najwa Chowdhury; Aaron Baker
Journal:  Behav Res Ther       Date:  2007-10-07

Review 4.  Empirically supported psychological treatments and the Research Domain Criteria (RDoC).

Authors:  Dean McKay; David F Tolin
Journal:  J Affect Disord       Date:  2016-10-20       Impact factor: 4.839

5.  Maximizing exposure therapy: an inhibitory learning approach.

Authors:  Michelle G Craske; Michael Treanor; Christopher C Conway; Tomislav Zbozinek; Bram Vervliet
Journal:  Behav Res Ther       Date:  2014-05-09

6.  Mediators of exposure therapy for youth obsessive-compulsive disorder: specificity and temporal sequence of client and treatment factors.

Authors:  Brian C Chu; Daniela B Colognori; Guang Yang; Min-ge Xie; R Lindsey Bergman; John Piacentini
Journal:  Behav Ther       Date:  2015-02-08

7.  Optimizing treatment for complex cases of childhood obsessive compulsive disorder: a preliminary trial.

Authors:  Tara S Peris; John Piacentini
Journal:  J Clin Child Adolesc Psychol       Date:  2012-05-01

8.  Psychometric evaluation of the Children's Yale-Brown Obsessive-Compulsive Scale.

Authors:  Eric A Storch; Tanya K Murphy; Gary R Geffken; Ohel Soto; Muhammad Sajid; Pam Allen; Jonathan W Roberti; Erin M Killiany; Wayne K Goodman
Journal:  Psychiatry Res       Date:  2004-11-30       Impact factor: 3.222

Review 9.  Ten ways to improve the use of statistical mediation analysis in the practice of child and adolescent treatment research.

Authors:  Marija Maric; Reinout W Wiers; Pier J M Prins
Journal:  Clin Child Fam Psychol Rev       Date:  2012-09

10.  Genetic and environmental influences on obsessive-compulsive behaviour across development: a longitudinal twin study.

Authors:  G Krebs; M A Waszczuk; H M S Zavos; D Bolton; T C Eley
Journal:  Psychol Med       Date:  2014-12-12       Impact factor: 7.723

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