Literature DB >> 324959

Studies on aculeacin. I. Isolation and characterization of aculeacin A.

K Mizuno, A Yagi, S Satoi, M Takada, M Hayashi.   

Abstract

Aculeacin A, a new antifungal antibiotic was isolated from the mycelial cake of Aspergillus aculeatus M-4214. The antibiotic is a white amorphous powder soluble in lower alcohols and hardly soluble in other organic solvents or water. Aculeacin A gave palmitic acid and five ninhydrin-positive products including theonine, hydroxyproline upon acid hydrolysis. The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity. Aculeacin A has relatively low toxicity in mice.

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Year:  1977        PMID： 324959     DOI： 10.7164/antibiotics.30.297

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  21 in total

Review 1.  Thom Award Lecture. Trends in the search for bioactive microbial metabolites.

Authors:  S Omura
Journal:  J Ind Microbiol       Date:  1992-09

2.  Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors.

Authors:  J Onishi; M Meinz; J Thompson; J Curotto; S Dreikorn; M Rosenbach; C Douglas; G Abruzzo; A Flattery; L Kong; A Cabello; F Vicente; F Pelaez; M T Diez; I Martin; G Bills; R Giacobbe; A Dombrowski; R Schwartz; S Morris; G Harris; A Tsipouras; K Wilson; M B Kurtz
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

3.  Newly discovered penicillin acylase activity of aculeacin A acylase from Actinoplanes utahensis.

Authors:  Jesús Torres-Bacete; Daniel Hormigo; Maribel Stuart; Miguel Arroyo; Pedro Torres; María P Castillón; Carmen Acebal; José L García; Isabel de la Mata
Journal:  Appl Environ Microbiol       Date:  2007-06-22       Impact factor: 4.792

Review 4.  Antifungal peptides: novel therapeutic compounds against emerging pathogens.

Authors:  A J De Lucca; T J Walsh
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

5.  Combined molecular and biochemical approach identifies Aspergillus japonicus and Aspergillus aculeatus as two species.

Authors:  L Parenicová; P Skouboe; J Frisvad; R A Samson; L Rossen; M ten Hoor-Suykerbuyk ; J Visser
Journal:  Appl Environ Microbiol       Date:  2001-02       Impact factor: 4.792

Review 6.  Compounds active against cell walls of medically important fungi.

Authors:  R F Hector
Journal:  Clin Microbiol Rev       Date:  1993-01       Impact factor: 26.132

7.  Enrichment for auxotrophic mutants in Saccharomyces cerevisiae using the cell wall inhibitor, echinocandin B.

Authors:  M T McCammon; L W Parks
Journal:  Mol Gen Genet       Date:  1982

8.  Synergistic action of nikkomycins X and Z with papulacandin B on whole cells and regenerating protoplasts of Candida albicans.

Authors:  R F Hector; P C Braun
Journal:  Antimicrob Agents Chemother       Date:  1986-03       Impact factor: 5.191

9.  A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase.

Authors:  C M Douglas; J A Marrinan; W Li; M B Kurtz
Journal:  J Bacteriol       Date:  1994-09       Impact factor: 3.490

10.  Use of cilofungin as direct fluorescent probe for monitoring antifungal drug-membrane interaction.

Authors:  Y T Ko; R D Ludescher; D J Frost; B P Wasserman
Journal:  Antimicrob Agents Chemother       Date:  1994-06       Impact factor: 5.191
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