BACKGROUND: Few prior studies have evaluated recovery after the onset of severe disability or have distinguished between the two subtypes of severe disability. OBJECTIVES: To identify the risk factors and intervening illnesses and injuries (i.e., events) that are associated with reduced recovery after episodes of progressive and catastrophic severe disability. DESIGN: Prospective longitudinal study of 754 nondisabled community-living persons, aged 70 years or older. SETTING: Greater New Haven, CT, March 1998 to December 2016. PARTICIPANTS: A total of 431 episodes of severe disability were evaluated from 385 participants: 116 progressive (115 participants) and 315 catastrophic (270 participants). MEASUREMENTS: Candidate risk factors were assessed every 18 months. Functional status and exposure to intervening events leading to hospitalization, emergency department visit, or restricted activity were assessed each month. Severe disability was defined as the need for personal assistance with three or more of four essential activities of daily living. Recovery was defined as return to independent function (no disability) within 6 months of developing severe disability. RESULTS: Recovery occurred among 35.3% (95% confidence interval [CI] = 26.0%-48.0%) and 61.6% (95% CI = 53.5%-70.9%) of the 116 progressive and 315 catastrophic severe disability episodes, respectively. In the multivariable analyses, lives alone, frailty, and intervening hospitalization were each independently associated with reduced recovery from progressive disability, with adjusted hazard ratios (95% CIs) of 0.31 (0.15-0.64), 0.23 (0.12-0.45), and 0.27 (0.08-0.95), respectively, whereas low functional self-efficacy, intervening restricted activity, and intervening hospitalization were each independently associated with reduced recovery from catastrophic disability, with adjusted hazard ratios (95% CIs) of 0.56 (0.40-0.81), 0.55 (0.35-0.85), and 0.45 (0.31-0.66), respectively. CONCLUSIONS: Recovery of independent function is considerably more likely after the onset of catastrophic than progressive severe disability, the risk factors for reduced recovery differ between progressive and catastrophic severe disability, and subsequent exposure to intervening illnesses and injuries considerably diminishes the likelihood of recovery from both subtypes of severe disability.
BACKGROUND: Few prior studies have evaluated recovery after the onset of severe disability or have distinguished between the two subtypes of severe disability. OBJECTIVES: To identify the risk factors and intervening illnesses and injuries (i.e., events) that are associated with reduced recovery after episodes of progressive and catastrophic severe disability. DESIGN: Prospective longitudinal study of 754 nondisabled community-living persons, aged 70 years or older. SETTING: Greater New Haven, CT, March 1998 to December 2016. PARTICIPANTS: A total of 431 episodes of severe disability were evaluated from 385 participants: 116 progressive (115 participants) and 315 catastrophic (270 participants). MEASUREMENTS: Candidate risk factors were assessed every 18 months. Functional status and exposure to intervening events leading to hospitalization, emergency department visit, or restricted activity were assessed each month. Severe disability was defined as the need for personal assistance with three or more of four essential activities of daily living. Recovery was defined as return to independent function (no disability) within 6 months of developing severe disability. RESULTS: Recovery occurred among 35.3% (95% confidence interval [CI] = 26.0%-48.0%) and 61.6% (95% CI = 53.5%-70.9%) of the 116 progressive and 315 catastrophic severe disability episodes, respectively. In the multivariable analyses, lives alone, frailty, and intervening hospitalization were each independently associated with reduced recovery from progressive disability, with adjusted hazard ratios (95% CIs) of 0.31 (0.15-0.64), 0.23 (0.12-0.45), and 0.27 (0.08-0.95), respectively, whereas low functional self-efficacy, intervening restricted activity, and intervening hospitalization were each independently associated with reduced recovery from catastrophic disability, with adjusted hazard ratios (95% CIs) of 0.56 (0.40-0.81), 0.55 (0.35-0.85), and 0.45 (0.31-0.66), respectively. CONCLUSIONS: Recovery of independent function is considerably more likely after the onset of catastrophic than progressive severe disability, the risk factors for reduced recovery differ between progressive and catastrophic severe disability, and subsequent exposure to intervening illnesses and injuries considerably diminishes the likelihood of recovery from both subtypes of severe disability.
Authors: Harvey Jay Cohen; John R Feussner; Morris Weinberger; Molly Carnes; Ronald C Hamdy; Frank Hsieh; Ciaran Phibbs; Donald Courtney; Kenneth W Lyles; Conrad May; Cynthia McMurtry; Leslye Pennypacker; David M Smith; Nina Ainslie; Thomas Hornick; Kayla Brodkin; Philip Lavori Journal: N Engl J Med Date: 2002-03-21 Impact factor: 91.245
Authors: Graziano Onder; Brenda W J H Penninx; Luigi Ferrucci; Linda P Fried; Jack M Guralnik; Marco Pahor Journal: J Gerontol A Biol Sci Med Sci Date: 2005-01 Impact factor: 6.053
Authors: Carlos A Vaz Fragoso; Evelyne A Gahbauer; Peter H Van Ness; John Concato; Thomas M Gill Journal: J Am Geriatr Soc Date: 2008-04-18 Impact factor: 5.562
Authors: Thomas M Gill; Dorothy I Baker; Margaret Gottschalk; Peter N Peduzzi; Heather Allore; Amy Byers Journal: N Engl J Med Date: 2002-10-03 Impact factor: 91.245
Authors: L Ferrucci; J M Guralnik; E Simonsick; M E Salive; C Corti; J Langlois Journal: J Gerontol A Biol Sci Med Sci Date: 1996-05 Impact factor: 6.053
Authors: Terrence E Murphy; Sui W Tsang; Linda S Leo-Summers; Mary Geda; Dae H Kim; Esther Oh; Heather G Allore; John Dodson; Alexandra M Hajduk; Thomas M Gill; Sarwat I Chaudhry Journal: Int J Stat Med Res Date: 2019-04-05