Literature DB >> 32490748

Gut Microbial Metabolites and Blood Pressure Regulation: Focus on SCFAs and TMAO.

Brian G Poll1, Muhammad Umar Cheema1, Jennifer L Pluznick1.   

Abstract

Shifts in the gut microbiome play a key role in blood pressure regulation, and changes in the production of gut microbial metabolites are likely to be a key mechanism. Known gut microbial metabolites include short-chain fatty acids, which can signal via G-protein-coupled receptors, and trimethylamine-N oxide. In this review, we provide an overview of gut microbial metabolites documented thus far to play a role in blood pressure regulation.

Entities:  

Keywords:  G-protein-coupled receptors; blood pressure; gut microbial metabolite; hypertension

Mesh：

Substances：

Year:  2020        PMID： 32490748      PMCID： PMC7474256          DOI： 10.1152/physiol.00004.2020

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  117 in total

1.  Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin-angiotensin system.

Authors:  Lei Wang; Qing Zhu; Aihua Lu; Xiaofen Liu; Linlin Zhang; Chuanming Xu; Xiyang Liu; Haobo Li; Tianxin Yang
Journal:  J Hypertens       Date:  2017-09       Impact factor: 4.844

2.  Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.

Authors:  M K Nøhr; K L Egerod; S H Christiansen; A Gille; S Offermanns; T W Schwartz; M Møller
Journal:  Neuroscience       Date:  2015-01-28       Impact factor: 3.590

Review 3.  Diversity, stability and resilience of the human gut microbiota.

Authors:  Catherine A Lozupone; Jesse I Stombaugh; Jeffrey I Gordon; Janet K Jansson; Rob Knight
Journal:  Nature       Date:  2012-09-13       Impact factor: 49.962

4.  (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.

Authors:  Andrew K P Taggart; Jukka Kero; Xiaodong Gan; Tian-Quan Cai; Kang Cheng; Marc Ippolito; Ning Ren; Rebecca Kaplan; Kenneth Wu; Tsuei-Ju Wu; Lan Jin; Chen Liaw; Ruoping Chen; Jeremy Richman; Daniel Connolly; Stefan Offermanns; Samuel D Wright; M Gerard Waters
Journal:  J Biol Chem       Date:  2005-06-01       Impact factor: 5.157

5.  Central GPR109A Activation Mediates Glutamate-Dependent Pressor Response in Conscious Rats.

Authors:  Samar Rezq; Abdel A Abdel-Rahman
Journal:  J Pharmacol Exp Ther       Date:  2015-11-30       Impact factor: 4.030

6.  Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.

Authors:  Jennifer L Pluznick; Ryan J Protzko; Haykanush Gevorgyan; Zita Peterlin; Arnold Sipos; Jinah Han; Isabelle Brunet; La-Xiang Wan; Federico Rey; Tong Wang; Stuart J Firestein; Masashi Yanagisawa; Jeffrey I Gordon; Anne Eichmann; Janos Peti-Peterdi; Michael J Caplan
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-11       Impact factor: 11.205

7.  Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide.

Authors:  Zeneng Wang; W H Wilson Tang; Jennifer A Buffa; Xiaoming Fu; Earl B Britt; Robert A Koeth; Bruce S Levison; Yiying Fan; Yuping Wu; Stanley L Hazen
Journal:  Eur Heart J       Date:  2014-02-03       Impact factor: 29.983

8.  Gut microbiota from twins discordant for obesity modulate metabolism in mice.

Authors:  Vanessa K Ridaura; Jeremiah J Faith; Federico E Rey; Jiye Cheng; Alexis E Duncan; Andrew L Kau; Nicholas W Griffin; Vincent Lombard; Bernard Henrissat; James R Bain; Michael J Muehlbauer; Olga Ilkayeva; Clay F Semenkovich; Katsuhiko Funai; David K Hayashi; Barbara J Lyle; Margaret C Martini; Luke K Ursell; Jose C Clemente; William Van Treuren; William A Walters; Rob Knight; Christopher B Newgard; Andrew C Heath; Jeffrey I Gordon
Journal:  Science       Date:  2013-09-06       Impact factor: 47.728

9.  Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism.

Authors:  Lin Ding; Mengru Chang; Ying Guo; Lingyu Zhang; Changhu Xue; Teruyoshi Yanagita; Tiantian Zhang; Yuming Wang
Journal:  Lipids Health Dis       Date:  2018-12-19       Impact factor: 3.876

10.  Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets.

Authors:  Trond Ulven
Journal:  Front Endocrinol (Lausanne)       Date:  2012-10-02       Impact factor: 5.555
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  16 in total

1.  Detection of low-mineral- and high-salt responsible caecal indigenous bacteria in ICR mice.

Authors:  Yumeng Xia; Takashi Kuda; Saori Nakamura; Hajime Takahashi; Bon Kimura
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2.  Black raspberry extract can lower serum LDL cholesterol via modulation of gut microbial composition and serum bile acid profile in rats fed trimethylamine-N-oxide with a high-fat diet.

Authors:  Taehwan Lim; Kiuk Lee; Ryun Hee Kim; Kwang Hyun Cha; Song Yi Koo; Eun Chae Moon; Keum Taek Hwang
Journal:  Food Sci Biotechnol       Date:  2022-04-10       Impact factor: 3.231

3.  The Diagnostic Potential of Gut Microbiota-Derived Short-Chain Fatty Acids in Preeclampsia.

Authors:  Jialin Li; Lin Wang; Haimin Chen; Zhenglun Yang; Siqian Chen; Jiayi Wang; Yuping Zhou; Rongrong Xuan
Journal:  Front Pediatr       Date:  2022-06-03       Impact factor: 3.569

Review 4.  Tumor Necrosis Factor Alpha and the Gastrointestinal Epithelium: Implications for the Gut-Brain Axis and Hypertension.

Authors:  Christopher L Souders; Jasenka Zubcevic; Christopher J Martyniuk
Journal:  Cell Mol Neurobiol       Date:  2021-02-16       Impact factor: 5.046

5.  Physiology in Perspective: The New Normal-Life in a Pandemic.

Authors:  Gary C Sieck
Journal:  Physiology (Bethesda)       Date:  2020-07-01

Review 6.  Intravenous and Oral Fluid Therapy in Neonatal Calves With Diarrhea or Sepsis and in Adult Cattle.

Authors:  Peter D Constable; Florian M Trefz; Ismail Sen; Joachim Berchtold; Mohammad Nouri; Geoffrey Smith; Walter Grünberg
Journal:  Front Vet Sci       Date:  2021-01-27

7.  Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study.

Authors:  Gaurav Baranwal; Rachel Pilla; Bethany L Goodlett; Aja K Coleman; Cristina M Arenaz; Arul Jayaraman; Joseph M Rutkowski; Robert C Alaniz; Brett M Mitchell
Journal:  Biomolecules       Date:  2021-09-21

8.  Circulating Trimethylamine N-Oxide Is Associated with Increased Risk of Cardiovascular Mortality in Type-2 Diabetes: Results from a Dutch Diabetes Cohort (ZODIAC-59).

Authors:  Jose L Flores-Guerrero; Peter R van Dijk; Margery A Connelly; Erwin Garcia; Henk J G Bilo; Gerjan Navis; Stephan J L Bakker; Robin P F Dullaart
Journal:  J Clin Med       Date:  2021-05-24       Impact factor: 4.241

Review 9.  Microbial metabolites: cause or consequence in gastrointestinal disease?

Authors:  Serge Alain Fobofou; Tor Savidge
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2022-03-10       Impact factor: 4.871

Review 10.  19-hydroxy Steroids in the Aromatase Reaction: Review on Expression and Potential Functions.

Authors:  Tatjana Abaffy; Hiroaki Matsunami
Journal:  J Endocr Soc       Date:  2021-03-23
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