Jinjia Xu1, Jian Xu1, Haesoo Moon1, Herman O Sintim2, Hyowon Lee1. 1. Weldon School of Biomedical Engineering, Birck Nanotechnology Center, Center for Implantable Devices, Purdue University, West Lafayette, Indiana 47906, United States. 2. Department of Chemistry, Center for Drug Discovery, Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana 47906, United States.
Abstract
Here, we describe the design, synthesis, and evaluation of two kinds of multifunctional zwitterionic linear poly(carboxybetaine thiophene) (PCBTh) and porous poly(carboxybetaine thiophene-co-9,9'-bifluoreneylidene) (PCBTh-coBF) polymers, which can be facilely synthesized using Yamamoto and Suzuki polycondensation, respectively. The integrations of zwitterionic polymer-based biomaterials that consist of conjugated polymer backbones, multifunctional zwitterionic side chains, and distorted units are designed and studied to address a key challenge of conjugated polymers in biomedical applications: biofouling phenomena that eventually lead to the failure and reduced lifetime of bioelectronics in the body. The introduction of a twisting unit into the polymer backbone allows us to tune the porosity, morphology, optical properties, and efficiency of antibiofouling features of resulting polymers. The PCBTh-coBF coated surface exhibits good conductivity, stability, hydrophilicity, and antibiofouling properties against protein adsorption, cell growth, and bacteria attachment, which may be useful for chronic in vivo bioelectronics applications by minimizing the foreign body response.
Here, we describe the design, synthesis, and evaluation of two kinds of multifunctional zwitterionic linear poly(carboxybetaine thiophene) (pan class="Chemical">PCBTh) and porous poly(carboxybetaine thiophene-co-9,9'-bifluoreneylidene) (PCBTh-coBF) polymers, which can be facilely synthesized using Yamamoto and Suzuki polycondensation, respectively. The integrations of zwitterionic polymer-based biomaterials that consist of conjugated polymer backbones, multifunctional zwitterionic side chains, and distorted units are designed and studied to address a key challenge of conjugated polymers in biomedical applications: biofouling phenomena that eventually lead to the failure and reduced lifetime of bioelectronics in the body. The introduction of a twisting unit into the polymer backbone allows us to tune the porosity, morphology, optical properties, and efficiency of antibiofouling features of resulting polymers. The PCBTh-coBF coated surface exhibits good conductivity, stability, hydrophilicity, and antibiofouling properties against protein adsorption, cell growth, and bacteria attachment, which may be useful for chronic in vivo bioelectronics applications by minimizing the foreign body response.
Authors: Hyunsu Park; Amir Hossein Raffiee; Simon W M John; Arezoo M Ardekani; Hyowon Lee Journal: Microsyst Nanoeng Date: 2018-11-05 Impact factor: 7.127
Authors: Jian Xu; Haesoo Moon; Jinjia Xu; Jongcheon Lim; Thomas Fischer; Helen A McNally; Herman O Sintim; Hyowon Lee Journal: ACS Appl Mater Interfaces Date: 2020-06-04 Impact factor: 9.229