Baihong Xie1, Ting Lei2, Nan Wang3, Hongmin Cai1, Jianbo Xian1,3, Miao He2, Lihe Zhang2, Hongning Xie4. 1. South China University of Technology, Guangzhou, China. 2. Department of Ultrasonic Medicine, Fetal Medical Center, First Affiliated Hospital of Sun Yat-sen University, Zhongshan Er Road 58, Guangzhou, 510080, Guangdong, China. 3. Guangzhou Aiyunji Information Technology Co., Ltd., Guangzhou, China. 4. Department of Ultrasonic Medicine, Fetal Medical Center, First Affiliated Hospital of Sun Yat-sen University, Zhongshan Er Road 58, Guangzhou, 510080, Guangdong, China. hongning_x@126.com.
Abstract
PURPOSE: Fetal brain abnormalities are some of the most common congenital malformations that may associated with syndromic and chromosomal malformations, and could lead to neurodevelopmental delay and mental retardation. Early prenatal detection of brain abnormalities is essential for informing clinical management pathways and consulting for parents. The purpose of this research is to develop computer-aided diagnosis algorithms for five common fetal brain abnormalities, which may provide assistance to doctors for brain abnormalities detection in antenatal neurosonographic assessment. METHODS: We applied a classifier to classify images of fetal brain standard planes (transventricular and transcerebellar) as normal or abnormal. The classifier was trained by image-level labeled images. In the first step, craniocerebral regions were segmented from the ultrasound images. Then, these segmentations were classified into four categories. Last, the lesions in the abnormal images were localized by class activation mapping. RESULTS: We evaluated our algorithms on real-world clinical datasets of fetal brain ultrasound images. We observed that the proposed method achieved a Dice score of 0.942 on craniocerebral region segmentation, an average F1-score of 0.96 on classification and an average mean IOU of 0.497 on lesion localization. CONCLUSION: We present computer-aided diagnosis algorithms for fetal brain ultrasound images based on deep convolutional neural networks. Our algorithms could be potentially applied in diagnosis assistance and are expected to help junior doctors in making clinical decision and reducing false negatives of fetal brain abnormalities.
PURPOSE:Fetal brain abnormalities are some of the most common congenital malformations that may associated with syndromic and chromosomal malformations, and could lead to neurodevelopmental delay and mental retardation. Early prenatal detection of brain abnormalities is essential for informing clinical management pathways and consulting for parents. The purpose of this research is to develop computer-aided diagnosis algorithms for five common fetal brain abnormalities, which may provide assistance to doctors for brain abnormalities detection in antenatal neurosonographic assessment. METHODS: We applied a classifier to classify images of fetal brain standard planes (transventricular and transcerebellar) as normal or abnormal. The classifier was trained by image-level labeled images. In the first step, craniocerebral regions were segmented from the ultrasound images. Then, these segmentations were classified into four categories. Last, the lesions in the abnormal images were localized by class activation mapping. RESULTS: We evaluated our algorithms on real-world clinical datasets of fetal brain ultrasound images. We observed that the proposed method achieved a Dice score of 0.942 on craniocerebral region segmentation, an average F1-score of 0.96 on classification and an average mean IOU of 0.497 on lesion localization. CONCLUSION: We present computer-aided diagnosis algorithms for fetal brain ultrasound images based on deep convolutional neural networks. Our algorithms could be potentially applied in diagnosis assistance and are expected to help junior doctors in making clinical decision and reducing false negatives of fetal brain abnormalities.