Literature DB >> 32477691

FHIR Lab Reports: using SMART on FHIR and CDS Hooks to increase the clinical utility of pharmacogenomic laboratory test results.

Michael Watkins1, Karen Eilbeck1.   

Abstract

Laboratory tests are a common aspect of clinical care and are the primary source of clinical genomic data. However, most laboratories use PDF documents to store and exchange the results of these tests. This locks the data into a static format and leaves the results only human-readable. The ordering clinician uses the results, but after that the information is unlikely to be used again. Future use would require a clinician to know that the test was performed, know where to find the PDF report, and take the time to open it and determine relevance to that future scenario. New computational standards such as SMART on FHIR and CDS Hooks present opportunities to better utilize these results, both physically upon receipt and asynchronously in future clinical encounters for that patient. Full app available at https://github.com/mwatkin8/FHIR-Lab-Reports-App. Demo available at http://hematite.genetics.utah.edu/FHIR-Lab-Reports/. ©2020 AMIA - All rights reserved.

Entities:  

Year:  2020        PMID: 32477691      PMCID: PMC7233102     

Source DB:  PubMed          Journal:  AMIA Jt Summits Transl Sci Proc


  16 in total

1.  Genetic Test Availability And Spending: Where Are We Now? Where Are We Going?

Authors:  Kathryn A Phillips; Patricia A Deverka; Gillian W Hooker; Michael P Douglas
Journal:  Health Aff (Millwood)       Date:  2018-05       Impact factor: 6.301

Review 2.  Settling the score: variant prioritization and Mendelian disease.

Authors:  Karen Eilbeck; Aaron Quinlan; Mark Yandell
Journal:  Nat Rev Genet       Date:  2017-08-14       Impact factor: 53.242

3.  Principles and Recommendations for Standardizing the Use of the Next-Generation Sequencing Variant File in Clinical Settings.

Authors:  Ira M Lubin; Nazneen Aziz; Lawrence J Babb; Dennis Ballinger; Himani Bisht; Deanna M Church; Shaun Cordes; Karen Eilbeck; Fiona Hyland; Lisa Kalman; Melissa Landrum; Edward R Lockhart; Donna Maglott; Gabor Marth; John D Pfeifer; Heidi L Rehm; Somak Roy; Zivana Tezak; Rebecca Truty; Mollie Ullman-Cullere; Karl V Voelkerding; Elizabeth A Worthey; Alexander W Zaranek; Justin M Zook
Journal:  J Mol Diagn       Date:  2017-03-18       Impact factor: 5.568

4.  GENOMICS. A federated ecosystem for sharing genomic, clinical data.

Authors: 
Journal:  Science       Date:  2016-06-10       Impact factor: 47.728

5.  Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade.

Authors:  Yuan Ji; Jennifer M Skierka; Joseph H Blommel; Brenda E Moore; Douglas L VanCuyk; Jamie K Bruflat; Lisa M Peterson; Tamra L Veldhuizen; Numrah Fadra; Sandra E Peterson; Susan A Lagerstedt; Laura J Train; Linnea M Baudhuin; Eric W Klee; Matthew J Ferber; Suzette J Bielinski; Pedro J Caraballo; Richard M Weinshilboum; John L Black
Journal:  J Mol Diagn       Date:  2016-03-03       Impact factor: 5.568

Review 6.  Clinical exome sequencing reports: current informatics practice and future opportunities.

Authors:  Rajeswari Swaminathan; Yungui Huang; Caroline Astbury; Sara Fitzgerald-Butt; Katherine Miller; Justin Cole; Christopher Bartlett; Simon Lin
Journal:  J Am Med Inform Assoc       Date:  2017-11-01       Impact factor: 4.497

7.  Technical desiderata for the integration of genomic data into Electronic Health Records.

Authors:  Daniel R Masys; Gail P Jarvik; Neil F Abernethy; Nicholas R Anderson; George J Papanicolaou; Dina N Paltoo; Mark A Hoffman; Isaac S Kohane; Howard P Levy
Journal:  J Biomed Inform       Date:  2011-12-27       Impact factor: 6.317

8.  Reanalysis of Clinical Exome Sequencing Data.

Authors:  Pengfei Liu; Linyan Meng; Elizabeth A Normand; Fan Xia; Xiaofei Song; Andrew Ghazi; Jill Rosenfeld; Pilar L Magoulas; Alicia Braxton; Patricia Ward; Hongzheng Dai; Bo Yuan; Weimin Bi; Rui Xiao; Xia Wang; Theodore Chiang; Francesco Vetrini; Weimin He; Hanyin Cheng; Jie Dong; Charul Gijavanekar; Paul J Benke; Jonathan A Bernstein; Tanya Eble; Yasemen Eroglu; Deanna Erwin; Luis Escobar; James B Gibson; Karen Gripp; Soledad Kleppe; Mary K Koenig; Andrea M Lewis; Marvin Natowicz; Pedro Mancias; LaKeesha Minor; Fernando Scaglia; Christian P Schaaf; Haley Streff; Hilary Vernon; Crescenda L Uhles; Elaine H Zackai; Nan Wu; V Reid Sutton; Arthur L Beaudet; Donna Muzny; Richard A Gibbs; Jennifer E Posey; Seema Lalani; Chad Shaw; Christine M Eng; James R Lupski; Yaping Yang
Journal:  N Engl J Med       Date:  2019-06-20       Impact factor: 91.245

9.  A Pharmacogenomics Clinical Decision Support Service Based on FHIR and CDS Hooks.

Authors:  R H Dolin; A Boxwala; J Shalaby
Journal:  Methods Inf Med       Date:  2019-01-03       Impact factor: 2.176

10.  Systematic reanalysis of clinical exome data yields additional diagnoses: implications for providers.

Authors:  Aaron M Wenger; Harendra Guturu; Jonathan A Bernstein; Gill Bejerano
Journal:  Genet Med       Date:  2016-07-21       Impact factor: 8.822

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  6 in total

Review 1.  Systemic Barriers to Risk-Reducing Interventions for Hereditary Cancer Syndromes: Implications for Health Care Inequities.

Authors:  Kathleen F Mittendorf; Sarah Knerr; Tia L Kauffman; Nangel M Lindberg; Katherine P Anderson; Heather Spencer Feigelson; Marian J Gilmore; Jessica Ezzell Hunter; Galen Joseph; Stephanie A Kraft; Jamilyn M Zepp; Sapna Syngal; Benjamin S Wilfond; Katrina A B Goddard
Journal:  JCO Precis Oncol       Date:  2021-11-03

2.  Applying FHIR Genomics for Research - From Sequencing to Database.

Authors:  Sean Hernandez; Karen Fairchild; Mark Pemberton; Jonathan Dahmer; Wei Zhang; Matvey B Palchuk; Umit Topaloglu
Journal:  AMIA Annu Symp Proc       Date:  2022-05-23

3.  Using CDS Hooks to increase SMART on FHIR app utilization: a cluster-randomized trial.

Authors:  Keaton L Morgan; Polina V Kukhareva; Phillip B Warner; Jonah Wilkof; Meir Snyder; Devin Horton; Troy Madsen; Joseph Habboushe; Kensaku Kawamoto
Journal:  J Am Med Inform Assoc       Date:  2022-08-16       Impact factor: 7.942

Review 4.  Contemporary clinical decision support standards using Health Level Seven International Fast Healthcare Interoperability Resources.

Authors:  Howard R Strasberg; Bryn Rhodes; Guilherme Del Fiol; Robert A Jenders; Peter J Haug; Kensaku Kawamoto
Journal:  J Am Med Inform Assoc       Date:  2021-07-30       Impact factor: 7.942

5.  Genomic considerations for FHIR®; eMERGE implementation lessons.

Authors:  Mullai Murugan; Lawrence J Babb; Casey Overby Taylor; Luke V Rasmussen; Robert R Freimuth; Eric Venner; Fei Yan; Victoria Yi; Stephen J Granite; Hana Zouk; Samuel J Aronson; Kevin Power; Alex Fedotov; David R Crosslin; David Fasel; Gail P Jarvik; Hakon Hakonarson; Hana Bangash; Iftikhar J Kullo; John J Connolly; Jordan G Nestor; Pedro J Caraballo; WeiQi Wei; Ken Wiley; Heidi L Rehm; Richard A Gibbs
Journal:  J Biomed Inform       Date:  2021-04-28       Impact factor: 8.000

Review 6.  New Standards for Clinical Decision Support: A Survey of The State of Implementation.

Authors:  Peter Taber; Christina Radloff; Guilherme Del Fiol; Catherine Staes; Kensaku Kawamoto
Journal:  Yearb Med Inform       Date:  2021-09-03
  6 in total

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