Jie Wang1, Zhuo Chen2, Meiyan Sun3, Huijing Xu3, Yufei Gao2, Jingwen Liu4, Miao Li5. 1. Department of Neurology, The China-Japan Union Hospital, Jilin University, Changchun 130033, China; Jilin Province Neuro-oncology Engineering Laboratory, Jilin University, Changchun 130033, China. 2. Department of Neurosurgery, The China-Japan Union Hospital, Jilin University, Changchun 130033, China; Jilin Province Neuro-oncology Engineering Laboratory, Jilin University, Changchun 130033, China; Jilin Provincial Key Laboratory of Neuro-oncology, Jilin University, Changchun 130033, China. 3. Medical Examination College, Jilin Medical University, Jilin, 132013, China. 4. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77030, USA. 5. Department of Neurosurgery, The China-Japan Union Hospital, Jilin University, Changchun 130033, China; Jilin Province Neuro-oncology Engineering Laboratory, Jilin University, Changchun 130033, China; Jilin Provincial Key Laboratory of Neuro-oncology, Jilin University, Changchun 130033, China. Electronic address: limiao@jlu.edu.cn.
Abstract
BACKGROUND: Mesenchymal stem cells (MSCs) are multipotent, genomic stable, self-renewable, and culturally expandable adult stem cells. MSCs facilitate tissue development, maintenance and repair, and produce secretory factors that support engraftment and trophic functions, marking them an attractive option in cell therapy, regenerative medicine and tissue engineering. METHOD: In this review, we summarize the recent researches regarding the isolation and characterization of MSCs, therapeutic applications and advanced engineering techniques. We also discuss the advantages and limitations that remain to be overcome for MSCs based therapy. RESULTS: It has been demonstrated that MSCs are able to modulate endogenous tissue and immune cells. Preclinical studies and early phase clinical trials have shown their great potential for tissue engineering of bone, cartilage, marrow stroma, muscle, fat, and other connective tissues. CONCLUSIONS: MSC-based therapy show considerable promise to rebuild damaged or diseased tissues, which could be a promising therapeutic method for regeneration medicine.
BACKGROUND: Mesenchymal stem cells (MSCs) are multipotent, genomic stable, self-renewable, and culturally expandable adult stem cells. MSCs facilitate tissue development, maintenance and repair, and produce secretory factors that support engraftment and trophic functions, marking them an attractive option in cell therapy, regenerative medicine and tissue engineering. METHOD: In this review, we summarize the recent researches regarding the isolation and characterization of MSCs, therapeutic applications and advanced engineering techniques. We also discuss the advantages and limitations that remain to be overcome for MSCs based therapy. RESULTS: It has been demonstrated that MSCs are able to modulate endogenous tissue and immune cells. Preclinical studies and early phase clinical trials have shown their great potential for tissue engineering of bone, cartilage, marrow stroma, muscle, fat, and other connective tissues. CONCLUSIONS: MSC-based therapy show considerable promise to rebuild damaged or diseased tissues, which could be a promising therapeutic method for regeneration medicine.
Authors: Asim Cengiz Akbulut; Grzegorz B Wasilewski; Nikolas Rapp; Francesco Forin; Heike Singer; Katrin J Czogalla-Nitsche; Leon J Schurgers Journal: Front Cell Dev Biol Date: 2021-01-28
Authors: Alexey A Ivanov; Alla V Kuznetsova; Olga P Popova; Tamara I Danilova; Oleg O Yanushevich Journal: Int J Mol Sci Date: 2021-12-15 Impact factor: 5.923