Literature DB >> 32467953

Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy.

Dali Sun1, Li Yang2, Christopher J Lyon2, Tony Hu2.   

Abstract

Nanoparticle-enhanced assays read by high-magnification dark-field microscopy require time-intensive analysis methods subject to selection bias, which can be resolved by using low magnification dark-field assays (LMDFA), at the cost of reduced sensitivity. We have simulated and experimentally validated a tunable linker-based signal amplification strategy yielding 6-fold enhanced LMDFA sensitivity.

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Year:  2020        PMID： 32467953      PMCID： PMC7386073          DOI： 10.1039/d0tb00350f

Source DB:  PubMed          Journal:  J Mater Chem B        ISSN： 2050-750X            Impact factor:   6.331


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