| Literature DB >> 32467386 |
Deborah Nejman1, Ilana Livyatan1,2, Garold Fuks3, Noam Shental4, Ravid Straussman5, Nancy Gavert1, Yaara Zwang1, Leore T Geller1, Aviva Rotter-Maskowitz1, Roi Weiser6,7, Giuseppe Mallel1, Elinor Gigi1, Arnon Meltser1, Gavin M Douglas8, Iris Kamer9, Vancheswaran Gopalakrishnan10, Tali Dadosh11, Smadar Levin-Zaidman11, Sofia Avnet12, Tehila Atlan13, Zachary A Cooper14, Reetakshi Arora10, Alexandria P Cogdill15, Md Abdul Wadud Khan10, Gabriel Ologun10, Yuval Bussi1,2,16, Adina Weinberger1,2, Maya Lotan-Pompan1,2, Ofra Golani17, Gili Perry18, Merav Rokah19, Keren Bahar-Shany18, Elisa A Rozeman20, Christian U Blank20, Anat Ronai21, Ron Shaoul21, Amnon Amit22,23, Tatiana Dorfman24,25, Ran Kremer26, Zvi R Cohen7,27, Sagi Harnof7,28, Tali Siegal29, Einav Yehuda-Shnaidman30, Einav Nili Gal-Yam31, Hagit Shapira30, Nicola Baldini12,32, Morgan G I Langille8,33, Alon Ben-Nun7,19, Bella Kaufman7,9, Aviram Nissan34, Talia Golan7,9, Maya Dadiani18, Keren Levanon7,18, Jair Bar7,9, Shlomit Yust-Katz7,29, Iris Barshack7,35, Daniel S Peeper36, Dan J Raz37, Eran Segal1,2, Jennifer A Wargo10,15, Judith Sandbank30.
Abstract
Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.Entities:
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Year: 2020 PMID： 32467386 PMCID： PMC7757858 DOI： 10.1126/science.aay9189
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728